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Application of Lippialactone in preparing vascular dilation drug

A technology for dilating blood vessels and drugs, which is applied in the application field of Lippialactone in the preparation of vasodilating drugs, and can solve problems such as no breakthrough progress

Inactive Publication Date: 2016-03-02
ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment of hypertension and its related vascular complications and / or complications mainly relies on western medicine, but there has been no breakthrough in the treatment of hypertension with traditional Chinese medicine

Method used

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  • Application of Lippialactone in preparing vascular dilation drug
  • Application of Lippialactone in preparing vascular dilation drug
  • Application of Lippialactone in preparing vascular dilation drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: the preparation of the compound Lippialactone tablet involved in the present invention:

[0014] Get 5 grams of compound Lippialactone, add 195 grams of dextrin, mix well, and make 1000 tablets with a conventional tablet machine.

Embodiment 2

[0015] Embodiment 2: the preparation of the compound Lippialactone capsules involved in the present invention:

[0016] Get 5 grams of the compound Lippialactone, add 195 grams of starch, mix well, and pack into capsules to make 1000 capsules.

[0017] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0018] Experimental example 1 Preparation of isolated rat aortic ring

[0019] Experimental procedure: clean grade male Sprague=Dawley (SD) rats, weighing 240-260 g. Rapidly dissociate the thoracic aorta of SD rats and place at 4°C containing 95% O 2 and 5% CO 2 In the K-H liquid pre-saturated with mixed gas, the surrounding connective tissue was removed and cut into vascular rings of 3-4 mm. During this period, care should be taken to protect the intima of the vascular ring from damage. According to the needs of the experiment, the method of rubbing the inner surface of the vascular ring with a cotton swab was used to prepare a part of the vascular ring as a model in which the endothelium was removed. Then the vascular ring was suspended in a bath pre-prepared with 10mL K-H solution, one end was fixed, and the other end was connected to the Medlab biological signal acquisition system through a tension transducer. In continuous pass 95% O2 and 5% CO 2 In the state of mixed...

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Abstract

The invention discloses application of Lippialactone in preparing a vascular dilation drug, in particular application of the Lippialactone in preparing drugs for lowering blood pressure and for resisting such vascular diseases as angina and the like. The application of the Lippialactone in preparing the vascular dilation drug is disclosed for the first time; the Lippialactone, since framework belongs to a totally new framework type, the activity on vascular dilation is extraordinary and the application is impossible to be implicated by other compounds, has outstanding substantive features; and meanwhile, the Lippialactone, for vascular dilation, has obviously achieved a significant progress.

Description

technical field [0001] The present invention relates to the new application of the compound Lippialactone, in particular to the application of Lippialactone in the preparation of vasodilators. Background technique [0002] In my country, hypertension is a common cardiovascular disease with a high prevalence rate, and the complications and / or comorbidities of heart, brain, kidney, limbs and other vascular complications and / or comorbidities rank first among all kinds of diseases , is extremely harmful to human health. According to the national census results in 1991, the prevalence rate of hypertension in my country increased by 275% within 13 months. At present, the treatment of hypertension and its related vascular complications and / or comorbidities mainly relies on western medicine, but there has been no breakthrough in the treatment of hypertension with traditional Chinese medicine. [0003] The compound Lippialactone involved in the present invention is a new compound pu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/366A61K9/20A61K9/48A61P9/08A61P9/10A61P9/12
Inventor 田丽华
Owner ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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