Medicine composition for treating sicca syndrome and preparation method and application of medicine composition

A composition and drug technology, applied in the direction of drug combination, pharmaceutical formula, medical preparation containing active ingredients, etc., can solve the problems of poor clinical improvement, diverse lesions of Sjögren's syndrome, lingering disease, etc., to reduce pathological manifestations and Inflammation degree, improving exocrine gland function, reducing the effect of pathological manifestations

Inactive Publication Date: 2016-02-24
DONGFANG HOSPITAL BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, due to the diverse lesions of Sjögren's syndrome, complicated pathogenesis, lingering condition, and profound disease location, most of the Chinese patent medicines currently used in clinical practice are more than nourishing yin, not enough for promoting blood circulation and detoxification, and the clinical improvement is not good.
And most of them are simple patchwork of traditional Chinese medicines, lack of systematic theoretical support; lack of systematic clinical and experimental data support; inconvenient to use during the medication process, so the curative effect and process are yet to be evaluated

Method used

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  • Medicine composition for treating sicca syndrome and preparation method and application of medicine composition
  • Medicine composition for treating sicca syndrome and preparation method and application of medicine composition
  • Medicine composition for treating sicca syndrome and preparation method and application of medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] This embodiment provides a pharmaceutical composition, the specific prescription is as follows: 15g of Salvia miltiorrhiza, 15g of Scrophulariae scrophulariae, 15g of fried white peony, 8g of Chuanxiong, 15g of Nansha ginseng, 15g of raw rehmannia, 12g of dendrobium, 5g of raw licorice.

[0032] This embodiment also provides the preparation method of the above-mentioned pharmaceutical composition, and the specific preparation process includes the following steps:

[0033] (1) take each raw material by prescription quantity;

[0034] (2) Put all the raw materials in 8 times the amount of water and decoct twice, the first time for 2 hours, the second time for 1.5 hours, filter the decoction, concentrate the filtrate to 2g of medicinal materials per 1ml, add 1 times the concentration Amount of ethanol, stir evenly, let stand for 24h, filter, the medicinal liquid depressurizes to recover ethanol, concentrate to a clear paste with a relative density of 1.25-1.30 (80°C).

[...

Embodiment 2

[0037] This example provides a pharmaceutical composition. Compared with Example 1, the only difference is that the prescription is different, as follows: Salvia miltiorrhiza 10g, Scrophulariaceae 9g, fried white peony root 6g, Chuanxiong 3g, Nansha ginseng 9g, Shengdi 10g, Dendrobium 6g, raw licorice 2g.

[0038] This embodiment also provides the preparation method of the above-mentioned pharmaceutical composition, and the specific preparation process includes the following steps:

[0039] (1) take each raw material by prescription quantity;

[0040] (2) Put all the raw materials in 6 times the amount of water and decoct twice, the first time for 2 hours, the second time for 1.5 hours, filter the decoction, concentrate the filtrate to 2g of medicinal materials per 1ml, add 1.5 times of the concentrated solution Amount of ethanol, stir evenly, let stand for 24h, filter, the medicinal liquid depressurizes to recover ethanol, concentrate to a clear paste with a relative density...

Embodiment 3

[0043] This example provides a pharmaceutical composition. Compared with Example 1, the only difference is that the prescription is different, as follows: 15g of Salvia miltiorrhiza, 15g of Radix Scrophulariae, 15g of fried white peony root, 10g of Rhizoma Chuanxiong, 15g of Nansha ginseng, 15g of Shengdi, Dendrobium 12g, raw licorice 10g.

[0044] This embodiment also provides the preparation method of the above-mentioned pharmaceutical composition, and the specific preparation process includes the following steps:

[0045] (1) take each raw material by prescription quantity;

[0046] (2) Put all raw materials in 10 times the amount of water and decoct 3 times, the first time for 2 hours, the second time for 1.5 hours, the second time for 1 hour, filter the decoction, concentrate the filtrate to 2g of medicinal materials per 1ml, add equivalent Add 1 times the amount of ethanol in the concentrated solution, stir well, let it stand for 24 hours, filter, recover the ethanol fr...

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Abstract

The invention relates to the field of medicine preparations, in particular to a medicine composition. The medicine composition is prepared from, by weight, 10-15 parts of salvia miltiorrhiza, 9-15 parts of radix scrophulariae, 6-15 parts of parched white peony roots, 3-10 parts of ligusticum wallichii, 9-15 parts of adenophora tetraphylla, 10-15 parts of rehmannia roots, 6-12 parts of dendrobe and 2-10 parts of fresh liquorice. The medicine composition is a pure traditional Chinese medicine preparation, has an immunity adjusting function, and can remarkably relieve pathological manifestations and inflammation degree of patients and improve exocrine gland functions of the patients; the medicine is safe, free of obvious side effects and good in compliance in the long terms and has an exact effect.

Description

technical field [0001] The invention relates to traditional Chinese medicine preparations, in particular to a pharmaceutical composition for treating Sjögren's syndrome, a preparation method and application thereof. Background technique [0002] Sjogren's syndrome is a relatively common disease among connective tissue diseases. Due to the obvious symptoms of dry mouth and dry eyes caused by the lesions of its exocrine glands, it seriously affects the quality of life of patients. At present, the early treatment of Sjogren's syndrome is mainly based on alternative therapy, such as bromhexine, artificial tears, etc. If it is accompanied by extraglandular manifestations, hydroxychloroquine sulfate, methotrexate, etc. are often given. Using traditional Chinese medicine to alleviate dry mouth and dry eyes has less toxic and side effects and good patient compliance. Chinese patent CN1554390 discloses a traditional Chinese medicine preparation for treating Sjögren's syndrome, which...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8984A61P43/00A61P37/02
Inventor 朱跃兰侯秀娟刘小平
Owner DONGFANG HOSPITAL BEIJING UNIV OF CHINESE MEDICINE
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