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Inclusion complex formed by ivermectin and cyclodextrin and preparation method of inclusion complex

A technology of ivermectin and cyclodextrin, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, drug combinations, etc., can solve the problem of poor water solubility and stability of ivermectin and increase costs To achieve the effect of accelerating drug absorption, improving stability, and reducing toxic and side effects

Inactive Publication Date: 2016-02-03
镇江泰飞尔医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the poor water solubility and stability of ivermectin, organic solvents are often used to dissolve and use, which increases the cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Weigh 20g of the original drug of ivermectin, dissolve it in 25ml of acetone, and stir evenly; weigh 200g of β-cyclodextrin, add a small amount of water to make a paste; slowly spray the ivermectin solution on the ring made into a paste On the dextrin, grind while spraying, and grind for 2 hours. After the milling is completed, the obtained product is put into an oven at 30° C., blown with nitrogen, and dried for 3 hours to obtain the inclusion complex of ivermectin and cyclodextrin.

Embodiment 2

[0020] Weigh 30g of the original drug of ivermectin, dissolve it in 30ml of acetone, and stir evenly; weigh 600g of β-cyclodextrin, add a small amount of water to make a paste; slowly spray the ivermectin solution on the ring made into a paste On the dextrin, grind while spraying, and grind for 3 hours. After the grinding is completed, the obtained product is put into an oven at 35° C., blown with nitrogen, and dried for 2 hours to obtain the inclusion complex of ivermectin and cyclodextrin.

Embodiment 3

[0022] Weigh 35g of ivermectin original drug, dissolve it in 45ml of acetone, and stir evenly; weigh 720g of β-cyclodextrin, add a small amount of water to make a paste; slowly spray the ivermectin solution on the ring made into a paste On the dextrin, grind while spraying, and grind for 2.5 hours. After the grinding is completed, the obtained product is put into an oven at 40° C., blown with nitrogen, and dried for 2 hours to obtain the inclusion complex of ivermectin and cyclodextrin.

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PUM

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Abstract

The invention discloses an inclusion complex formed by ivermectin and cyclodextrin and a preparation method of the inclusion complex. The inclusion complex is prepared by raw ivermectin and beta-cyclodextrin according to the mass ratio of 1:10-1:25. The preparation method includes: dissolving the raw ivermectin into an organic solvent, evenly spraying onto the pasty cyclodextrin, well mixing through colloid grinding, and feeding nitrogen and drying to obtain the inclusion complex. The inclusion complex and the preparation method of the inclusion complex have the advantages that the cavity structure of the cyclodextrin is used to wrap the ivermectin so as to increase the stability and water solubility of the ivermectin, the ivermectin can be prepared into a water solution, and consumption of the organic solvent is reduced.

Description

technical field [0001] The present invention relates to an inclusion complex of ivermectin, in particular to an inclusion complex formed of ivermectin and cyclodextrin, and also to an inclusion complex formed of ivermectin and cyclodextrin Preparation. Background technique [0002] Ivermectin is a new type of broad-spectrum, high-efficiency, and low-toxicity antibiotic antiparasitic drug, which has a good killing effect on internal and external parasites, especially nematodes and arthropods. Ivermectin is widely used in the agricultural field, and is mainly used for anti-parasites in the livestock, poultry and aquaculture industries. However, due to the poor water solubility and stability of ivermectin, organic solvents are often used to dissolve and use, which increases the cost. [0003] Studies have shown that cyclodextrin has a unique cavity structure. Insoluble compounds can form clathrates with various molecular ratios with cyclodextrins. Since the guest enters into...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K31/7048A61P33/02A61P33/14A61K47/69
Inventor 陈玉华
Owner 镇江泰飞尔医药有限公司
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