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Near-infrared diffusion correlation spectroscope for quickly measuring biological tissue blood flow volume

A technology of diffusion correlation spectroscopy and biological tissue, applied in the field of biomedical equipment, can solve the problems of inflexibility, complex instruments, and time resolution of only 5-10s, and achieve the effect of rapid measurement

Active Publication Date: 2016-01-27
INST OF FLUID PHYSICS CHINA ACAD OF ENG PHYSICS
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Problems solved by technology

[0004] Because commercial hardware correlators are expensive and inflexible, some researchers try to use software correlators to replace hardware correlators.
In 2001, D.Magatti et al. [6] Develop a software correlator for measuring particle motion. The principle of the software correlator is based on imitating the hardware correlator, but the time resolution is only 5-10s
But based on the characteristics of Fourier transform, the delay time is uniformly distributed, and it is difficult to cover a wide range of time scales
In addition, the delay time cannot be flexibly set
It can be seen that the time resolution of the existing software-based correlators is above the order of s; although the hardware correlator can realize the measurement of the order of ms, the instrument is complex
In addition, the delay time and time resolution of the existing correlators cannot be flexibly set

Method used

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  • Near-infrared diffusion correlation spectroscope for quickly measuring biological tissue blood flow volume
  • Near-infrared diffusion correlation spectroscope for quickly measuring biological tissue blood flow volume
  • Near-infrared diffusion correlation spectroscope for quickly measuring biological tissue blood flow volume

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Embodiment Construction

[0047] All features disclosed in this specification, or steps in all methods or processes disclosed, may be combined in any manner, except for mutually exclusive features and / or steps.

[0048] like figure 1 As shown, a structure diagram of a two-channel near-infrared diffusion correlation spectrometer is given. What is used in the present invention is a brand-new software correlator. The hardware of the software correlator includes a sampling clock, a counter and a computer. The light intensity sampling is realized by the counter controlled by the sampling clock, and the correlation calculation of the light intensity is realized by the computer; figure 2 The structure diagram of light intensity sampling is given. Since the intensity of the detected light is extremely weak, what the photodetector detects is an intermittent random photon flow, and converts the intermittent random photon flow into a random electrical pulse flow. The counter samples the total number of photons...

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Abstract

The invention discloses a near-infrared diffusion correlation spectroscope based on a brand-new software correlator. The time resolution can be flexibly arranged, and the time resolution of being smaller than 1 ms is achieved; delay times and the number of the delay times can also be flexibly arranged. When the number of the delay times is small, the correction Beer-Lambert law [8] provided by W. B. Baker and the like and used for measurement of the blood flow volume is adopted. When the number of the delay times is large, the biological tissue blood flow volume is obtained through the theoretical fitting method. A plurality of counters are adopted, and the near-infrared diffusion correlation spectroscope can be expanded into a multi-channel near-infrared diffusion correlation spectroscope easily. Hence, the near-infrared diffusion correlation spectroscope is fast, cheap and flexible.

Description

technical field [0001] The invention relates to the field of biomedical equipment, in particular to a near-infrared diffusion correlation spectrometer for quickly measuring the blood flow of biological tissues. Background technique [0002] Near-infrared light is a spectral segment of 600nm-1000nm. This spectrum has a very strong penetration in biological tissues and is called the optical window of biological tissues. At present, near-infrared diffusion optical spectroscopy (Diffuse Optical Spectroscopy (DOS), Near-infrared Spectroscopy (NIRS), Functional Near-infrared Spectroscopy (fNIRS)) and near-infrared diffusion correlation spectroscopy (DiffuseCorrelation Spectroscopy, DCS) developed based on this spectrum have been widely used. Medical research in stroke, brain trauma, functional brain imaging, cancer diagnosis, and muscle disease. [0003] Near-infrared diffusion correlation spectrometer provides a new technology for local blood flow measurement in deep biological ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/026
Inventor 王德田李泽仁彭其先朱礼国赵剑衡刘乔钟森城翟召辉李江杜良辉周平伟
Owner INST OF FLUID PHYSICS CHINA ACAD OF ENG PHYSICS
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