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Application of nonratt021972 small interfering RNA in the preparation of drugs for myocardial ischemia injury and sympathetic nerve disease

A technology of NONRATT021972, myocardial ischemia, applied in nervous system diseases, cardiovascular system diseases, drug combinations, etc., can solve the problem of unclear myocardial ischemia damage caused by small interference RNA, achieve prevention and treatment of sympathetic nervous diseases, reduce or alleviate The effect of myocardial ischemia injury

Active Publication Date: 2018-10-19
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Whether long non-coding RNA NONRATT021972 small interfering RNA can protect myocardial ischemic injury is not clear, whether it can act on cervical sympathetic ganglion nerve cells P2X 7 Receptors affect myocardial ischemia-induced sympathetic enhancement reflex to produce protective effects on myocardial, cardiovascular, and cardiac sympathetic nerve injuries. There is no literature report yet

Method used

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  • Application of nonratt021972 small interfering RNA in the preparation of drugs for myocardial ischemia injury and sympathetic nerve disease
  • Application of nonratt021972 small interfering RNA in the preparation of drugs for myocardial ischemia injury and sympathetic nerve disease
  • Application of nonratt021972 small interfering RNA in the preparation of drugs for myocardial ischemia injury and sympathetic nerve disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Use methods known in the art to make P2X suitable for cervical sympathetic ganglia or myocardium 7 The long non-coding ribonucleic acid NONRATT021972 small interfering ribonucleic acid preparation for oral, injection or topical application (including taking, etc.) for the prevention and treatment of receptor-mediated myocardial ischemic injury (acute coronary syndrome, etc.).

Embodiment 2

[0025] Use methods known in the art to make P2X suitable for cervical sympathetic ganglia or myocardium 7 A long non-coding ribonucleic acid NONRATT021972 small interfering ribonucleic acid preparation for oral, injection or topical application of receptor-mediated prevention and treatment of hypertension.

Embodiment 3

[0027] Use methods known in the art to produce P2X suitable for cervical sympathetic ganglia 7 A long non-coding ribonucleic acid NONRATT021972 small interfering ribonucleic acid preparation for oral, injection or topical application of receptor-mediated prevention and treatment of sympathetic nervous system diseases.

[0028] In order to better understand the essence of the present invention, the long non-coding ribonucleic acid NONRATT021972 small interfering ribonucleic acid pair P2X 7 The experiments and results of receptor-mediated myocardial ischemia injury and sympathetic nerve excitability research prove the use of NONRATT021972 small interference ribonucleic acid.

[0029] 1. Materials and methods.

[0030] 1. Animals and grouping.

[0031] Healthy Sprague-Dawley (SD) rats (body weight 180-220g), male, provided by the Laboratory Animal Science Department of School of Medicine, Nanchang University. The rats were randomly divided into control group; sham operation group; myocar...

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Abstract

The invention discloses a use of a long non-coding ribonucleic acid NONRATT021972 small interfering RNA in preparation of a drug for treating myocardial ischemia injury and sympathetic nerve diseases. Myocardial ischemia causes sympathetic nervous excitement reflex (such as blood pressure rising and heart rate and breathing acceleration) and further aggravates myocardial ischemia injury. Sympathetic nervous erethism can cause vasoconstriction function change thereby causing cardiovascular diseases. The long non-coding ribonucleic acid NONRATT021972 small interfering RNA can reduce myocardial ischemia and hypoxia exacerbation caused by myocardial ischemia injury-caused sympathetic nerve reflex, reduce myocardial ischemial injury, inhibit superior cervical ganglia erethism transmission, prevent and treat cardiovascular dysfunction-caused diseases, inhibit sympathetic nervous erethism and related pathological process and prevent and treat sympathetic nerve diseases. The long non-coding ribonucleic acid NONRATT021972 small interfering RNA in forms of an oral medicine, an injection, a lozenge or other local or whole body agents can treat the above diseases.

Description

Technical field [0001] The present invention belongs to the field of invention of drug application for myocardial ischemia injury, cardiovascular and sympathetic nervous system diseases. Background technique [0002] Acute myocardial ischemia is usually caused by an imbalance between myocardial oxygen demand and oxygen supply caused by coronary artery occlusion. Acute coronary syndrome refers to a series of symptoms caused by acute myocardial ischemia, including myocardial infarction (ST segment elevation and depression, Q-wave and non-Q-wave) and unstable angina. Clinical studies have found that removal of the superior cervical ganglion (SCG), stellate ganglion (SG) and other sympathetic ganglia can make 50-60% of patients with coronary heart disease disappear from angina pectoris, suggesting the innervation of the heart Sympathetic nerves are involved in myocardial ischemia injury response. The heart is simultaneously controlled by the cardio-sympathetic nerve and the cardio-...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K48/00A61K31/713A61P9/10A61P9/12A61P25/02
Inventor 梁尚栋涂桂花彭海英李桂林刘双梅徐宏张君孔繁君刘俊
Owner NANCHANG UNIV
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