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Preparation for promoting skin wound heeling, preparation method of preparation and application of preparation

A technology of wound healing and preparation, which is applied in the field of preparations and preparations to promote skin wound healing, which can solve the problems of few wound repairing products and no actual products for repairing wounds, and achieve rapid healing, low cost and low concentration Effect

Inactive Publication Date: 2016-01-20
GUANGZHOU SALIAI STEMCELL SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the prior art, fibroblasts and hyaluronic acid are mostly used in cosmetics, such as removing wrinkles, filling acne pits, etc., and there are few products that actually repair wounds. Stromal cell-derived factor-1 is mostly used in monitoring inflammation or The expression and level in a certain disease, not applied to the actual product used to repair wounds

Method used

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  • Preparation for promoting skin wound heeling, preparation method of preparation and application of preparation
  • Preparation for promoting skin wound heeling, preparation method of preparation and application of preparation

Examples

Experimental program
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Effect test

Embodiment 1

[0035] The preparation for promoting skin wound healing of this embodiment, the raw materials of the preparation include hyaluronic acid, autologous fibroblasts and stromal cell-derived factor-1, and the content of each raw material is:

[0036] Hyaluronic acid 0.05~1.0v / v%

[0037] Autologous fibroblasts 1.0×10 5 ~7.0×10 6 / mL

[0038] Stromal cell-derived factor-12.0~7.0ng / mL.

[0039] The preparation method of the preparation for promoting skin wound healing of the present embodiment comprises the following steps:

[0040] Step 1: Separation and culture of autologous fibroblasts to make a suspension of fibroblasts with a viability of more than 85%, and store them at 2-8°C for later use;

[0041] Step 2: Add 2.0-7.0 ng / mL stromal cell-derived factor-1 and 0.05-1.0 v / v% hyaluronic acid to the fibroblast suspension prepared in step 1, and mix well to prepare the preparation , Store at 2-8°C for later use.

Embodiment 2

[0043] This embodiment is a further optimization on the basis of Example 1, and the content of each raw material is:

[0044] Hyaluronic acid 0.1~0.5v / v%

[0045] Autologous fibroblasts 7.0×10 5 ~5.0×10 6 / mL

[0046] Stromal cell-derived factor-13.0~6.0ng / mL.

[0047] The preparation method of the preparation for promoting skin wound healing in this example is the same as that in Example 1, and will not be repeated here.

Embodiment 3

[0049] This embodiment is a further optimization on the basis of embodiment 2, and the content of each raw material is:

[0050] Hyaluronic Acid 0.2v / v%

[0051] Autologous fibroblasts 2.0×10 6 / mL

[0052] Stromal cell-derived factor - 15.0 ng / mL.

[0053] The preparation method of the preparation for promoting skin wound healing in this example is the same as that in Example 1, and will not be repeated here.

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Abstract

The invention relates to the technical field of biological medicine, in particular to a preparation for promoting skin wound heeling, a preparation method of the preparation and application of the preparation. The preparation for promoting the wound heeling comprises the following raw materials including hyaluronic acid, autologous fibroblasts and matrix cell derived factors; when the preparation is used as wound heeling medicine, the fast wound heeling effect can be achieved; an obvious curative effect is particularly achieved on the wound surface of a patient with large-area burns and scalds; the pain of the patient can be greatly reduced; the living quality of the patient is obviously improved; the concentration of each raw material ingredient in the preparation is lower, so that the cost is lower.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a preparation for promoting skin wound healing, a preparation method and application thereof. Background technique [0002] Skin wound healing is a repair process after skin tissue is damaged, and the repair process includes inflammatory response, cell proliferation, and new tissue remodeling. Inflammatory response includes various cytokines, leukocytes, etc.; cell regeneration includes fibroblast autologous proliferation or differentiation of mesenchymal cells into fibroblasts, etc.; tissue remodeling includes orderly rearrangement of fibroblasts into skin with certain functions organize. Therefore, fibroblasts are the main cell components in the dermis of the skin, and together with the collagen fibers, elastic fibers and matrix components secreted by themselves, they constitute the main body of the dermis. The main function of fibroblasts is to synthesize and secrete col...

Claims

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Application Information

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IPC IPC(8): A61K38/19C12N5/071A61P17/02A61K35/36A61K31/728
Inventor 陈海佳王一飞葛啸虎黎娟妹
Owner GUANGZHOU SALIAI STEMCELL SCI & TECH CO LTD
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