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Preparation method and preparation of absorbable micropore vacuum polysaccharide particles

A polysaccharide and vacuum technology, applied in the field of medicine, can solve the problems of bleeding volume and blood flow, adhesion, insufficient liquid absorption, and limited hemostatic effect, etc., and achieve simple equipment, industrial production, and convenient operation Effect

Inactive Publication Date: 2016-01-13
史跃
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the microstructure shows that the surface of the microspheres is cracked rather than microporous, and there is no vacuum inside. When it is applied to a large area of ​​soft tissue bleeding wound, the hemostatic effect is limited due to its insufficient adhesion and liquid absorption, and the amount of bleeding is relatively large. will be washed away by the blood flow for a long time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] In an embodiment of the present invention, a method for preparing absorbable microporous vacuum polysaccharide microspheres comprises the following steps:

[0031] (1) Expansion and gelatinization: Add potato starch into the extruder for puffing and gelatinization. During the extrusion process, the extrusion friction of the extruder generates heat. The pressure is 3MPa and the temperature is controlled at 175°C. In the high temperature state, the starch expands. Starch absorbs the heat and is subjected to strong shearing, the hydrogen bonds between molecular chains are broken, and the molecular chains move, causing partial disintegration of starch granules and gelatinization. It is extruded through the small hole on the extruder, and the temperature at the outlet is controlled at 120°C, and then put into the container for drying. That is to obtain expanded and gelatinized starch microspheres. The gelatinization degree after treatment by this method can reach more than...

Embodiment 2

[0037] In an embodiment of the present invention, a method for preparing absorbable microporous vacuum polysaccharide microspheres comprises the following steps:

[0038] (1) Expansion and gelatinization: Add potato starch into the extruder for puffing and gelatinization. During the extrusion process, the extrusion friction of the extruder generates heat. The pressure is 5MPa and the temperature is controlled at 185°C. In the high temperature state, the starch expands. Starch absorbs the heat and is subjected to strong shearing, the hydrogen bonds between molecular chains are broken, and the molecular chains move, causing partial disintegration of starch granules and gelatinization. It is extruded through the small hole on the extruder, and the temperature at the outlet is controlled at 120°C, and then put into the container for drying. That is to obtain expanded and gelatinized starch microspheres. The gelatinization degree after treatment by this method can reach more than...

Embodiment 3

[0044] In an embodiment of the present invention, a method for preparing absorbable microporous vacuum polysaccharide microspheres comprises the following steps:

[0045] (1) Expansion and gelatinization: Add potato starch into the extruder for puffing and gelatinization. During the extrusion process, the extrusion friction of the extruder generates heat. The pressure is 4MPa and the temperature is controlled at 180°C. In the high temperature state, the starch expands. Starch absorbs the heat and is subjected to strong shearing, the hydrogen bonds between molecular chains are broken, and the molecular chains move, causing partial disintegration of starch granules and gelatinization. It is extruded through the small hole on the extruder, and the temperature at the outlet is controlled at 120°C, and then put into the container for drying. That is to obtain expanded and gelatinized starch microspheres. The gelatinization degree after treatment by this method can reach more than...

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Abstract

The invention discloses a preparation method and preparation of absorbable micropore vacuum polysaccharide particles. The preparation method comprises the steps that plant starch is added to an extrusion mechanism for extrusion and gelatinization, after soybean oil, span 80 and polysorbate 80 are added for emulsification, perforating, crosslinking and desolvation are carried out, pigments and pyrogen are removed, drying, screening, packaging and sterilization are carried out, and the micropore vacuum polysaccharide particles are obtained. Packaging is carried out under the aseptic conditions, and cobalt 60 is used for sterilization. Micropore vacuum polysaccharide particles of 20 micrometers and 50 micrometers are used for preparing external-use hemostasis medicine, and the micropore vacuum polysaccharide particles of 51 micrometers to 100 micrometers are used for preparing intraoperative hemostasis medicine. The absorbable micropore vacuum polysaccharide particles are free of toxins, stimulation, immunogenicity, apyrogeneity and mutagenesis effects, and can be degraded and absorbed by human tissue and body fluid. Metabolite is CO2 and H2O. The absorbable micropore vacuum polysaccharide particles are directly used for bleeding wound surfaces, have the advantages of being good in biocompatibility and water absorption performance, short in hemostasis time and the like, are completely absorbed within 72 hours, and are free of adhesion.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a preparation method and application of absorbable microporous vacuum polysaccharide microspheres. Background technique [0002] At present, there are many kinds of hemostatic materials in the medical market, including traditional cotton materials, biomedical polymer materials, artificial protein dressings, mineral materials, liquid materials, metal dressings, etc. With the rapid development of modern science and technology, the research on medical hemostatic dressings has made very rapid progress. Various new types of medical dressings are constantly emerging, and their performance is getting better and better. Due to its high biological function and biological adaptability, natural active polymer biohemostatic materials have strong advantages in protecting wounds and accelerating wound healing. Therefore, in recent years, absorbable natural high Molecular hemostatic materials have attr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/44A61L15/64C08B30/18C08B31/00
Inventor 史跃史峰屹朱卉琪
Owner 史跃
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