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Application of a yb3+-based fluoride nanocrystal in the preparation of photodynamic therapy drugs

A technology of photodynamic therapy and nanocrystals, which can be used in drug combinations, medical preparations containing active ingredients, anti-tumor drugs, etc., and can solve problems such as poor penetration depth of excitation light

Active Publication Date: 2018-03-30
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the problem that the excitation light wavelength of the photosensitizer in the traditional photodynamic therapy causes the tissue penetration depth difference of the excitation light in the visible range, and proposes a method based on Yb 3+ Application of fluoride nanocrystals in the preparation of photodynamic therapy drugs

Method used

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  • Application of a yb3+-based fluoride nanocrystal in the preparation of photodynamic therapy drugs
  • Application of a yb3+-based fluoride nanocrystal in the preparation of photodynamic therapy drugs
  • Application of a yb3+-based fluoride nanocrystal in the preparation of photodynamic therapy drugs

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specific Embodiment approach 1

[0022] Specific implementation mode 1: In this implementation mode, a Yb-based 3+ The application of fluoride nanocrystals in the preparation of photodynamic therapy drugs will be based on Yb 3+ The fluoride nanocrystals are used as photosensitizers in photodynamic therapy, wherein the Yb-based 3+ The preparation method of the fluoride nanocrystal is realized according to the following steps:

[0023] 1. At room temperature, YbCl 3 ·6H 2 O joins in the reaction vessel, then adds oleic acid and octadecene, obtains mixed solution;

[0024] 2. Under the protection of Ar gas, heat the mixed solution obtained in step 1 to 160-170°C, stir and keep warm to make YbCl 3 ·6H 2 O is completely dissolved to obtain a reaction solution;

[0025] Three, the molar ratio is 5: (7 ~ 8) NaOH and NH 4 F is added in methanol, stirred to dissolve, obtains raw material liquid;

[0026] 4. Add the raw material solution in step 3 to the reaction solution obtained in step 2, stir and react and ...

specific Embodiment approach 2

[0030] Specific embodiment two: the difference between this embodiment and specific embodiment one is that step one YbCl 3 ·6H 2 The molar amount of O to the volume ratio of oleic acid is 1mmol: 6ml, YbCl 3 ·6H 2 The volume ratio of the molar amount of O to octadecene is 1 mmol: 15 ml. Other steps and parameters are the same as those in Embodiment 1.

specific Embodiment approach 3

[0031] Embodiment 3: This embodiment differs from Embodiment 1 or Embodiment 2 in that the stirring speed in step 2 is 300-500 r / min. Other steps and parameters are the same as those in Embodiment 1 or Embodiment 2.

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Abstract

Application of a Yb3+-based fluoride nanocrystal in the preparation of photodynamic therapy drugs, the invention belongs to the field of photodynamic therapy, and is used to solve the problem that the excitation light wavelength of photosensitizers in traditional photodynamic therapy causes excitation light tissue in the visible region. The problem of poor penetration depth. Yb3+-based fluoride nanocrystals are used as photosensitizers in photodynamic therapy, wherein the preparation method of Yb3+-based fluoride nanocrystals: 1. YbCl3 6H2O is added to oleic acid and octadecene; 2. Heating to dissolve; 3. , NaOH and NH4F were added into methanol; 4. heating reaction after mixing to remove water; 5. collecting NaYbF4 nanocrystals; 6. bonding with Tween; 7. bonding with folic acid again. The present invention uses a light source near 1 μm for irradiation, and its wavelength is within the range of the biological tissue transmission window, and can realize the treatment of deep tissue solid tumors.

Description

technical field [0001] The invention belongs to the field of photodynamic therapy, in particular to a Yb-based 3+ Application of fluoride nanocrystals in the preparation of photodynamic therapy drugs. Background technique [0002] Photodynamic therapy is a minimally invasive tumor treatment method that involves three basic elements: photosensitizer, excitation light and oxygen. When light of a specific wavelength irradiates the photosensitizer, the photosensitizer is excited, and the photosensitizer in the excited state undergoes a photochemical reaction with oxygen, converting oxygen into reactive oxygen species, causing irreversible tumor tissue damage. Compared with traditional chemotherapy, surgery and radiotherapy, PDT has several potential advantages: relatively non-invasive treatment, can accurately locate the target tumor tissue, repeatable treatment, relatively convenient operation and minimal side effects, etc. However, for traditional PDT, the excitation light w...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61P35/00
Inventor 张治国张佳音秦峰赵华郑仰东
Owner HARBIN INST OF TECH
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