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High-fidelity chitosan sodium hyaluronate eye drops and preparation method thereof

A technology of sodium hyaluronate and chitosan, which is applied in the field of medicine, can solve the problem that eye drops are easily contaminated and grow bacteria, and achieve the effects of preventing dry eye disease, strong irritation, and promoting the healing of corneal injuries

Active Publication Date: 2016-01-13
SHANGHAI HAOHAI BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, sodium hyaluronate is a macromolecular mucopolysaccharide, which is also conducive to the growth of bacteria. It is not a one-time package. After repeated use, the eye drops are easily contaminated and grow bacteria.

Method used

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  • High-fidelity chitosan sodium hyaluronate eye drops and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0034] 1. Drug formulation

[0035] A high-fidelity chitosan sodium hyaluronate eye drop, which comprises the following components: 0.05wt% chitosan, 0.3wt% sodium hyaluronate, 0.5wt% isotonic regulator, 0.8wt% auxiliary material , 0.01wt% borneol and a pH regulator, the remainder being water for injection, and the addition of the pH regulator is to make the pH of the composition 7.0.

[0036] 2. Drug preparation method

[0037] (1) First weigh 40% of the volume of water for injection and cool it to 50°C, add it to the reaction vessel, then weigh the formulated amount of sodium hyaluronate and chitosan, add it to the reaction vessel, stir evenly, and obtain the reaction solution for later use;

[0038] (2) Weigh the remaining water for injection and add it to another reaction vessel, and add the auxiliary materials of the formula amount into the reaction vessel;

[0039] (3) Take the borneol of formula quantity, and after dissolving with the alcohol of 95% by volume ratio, a...

Embodiment 2

[0043] 1. Drug formulation

[0044] A high-fidelity chitosan sodium hyaluronate eye drop, which comprises the following components: 0.1wt% chitosan, 0.1wt% sodium hyaluronate, 0.5wt% isotonic regulator, 0.5wt% auxiliary material , 0.02wt% borneol and a pH regulator, the remainder being water for injection, and the addition of the pH regulator is to make the pH of the composition 6.0.

[0045] 2. Drug preparation method

[0046] (1) First weigh 40% of the volume of water for injection and cool it to 55° C., add it to the reaction vessel, then weigh the sodium hyaluronate and chitosan of the formula and add it to the reaction vessel, stir evenly, and obtain the reaction solution for later use;

[0047] (2) Weigh the remaining water for injection and add it to another reaction vessel, and add the auxiliary materials of the formula amount into the reaction vessel;

[0048] (3) Take the borneol of formula quantity, and after dissolving with the alcohol of 95% by volume ratio, add...

Embodiment 3

[0052] 1. Drug formulation

[0053] A high-fidelity chitosan sodium hyaluronate eye drop, which comprises the following components: 0.03wt% chitosan, 0.2wt% sodium hyaluronate, 0.5wt% isotonic regulator, 1.0wt% auxiliary material , 0.02wt% borneol and a pH regulator, the remainder being water for injection, and the addition of the pH regulator is to make the pH of the composition 6.5.

[0054] 2. Drug preparation method

[0055] (1) First weigh 50% of the volume of water for injection and cool it to 60° C., add it to the reaction vessel, then weigh the formulated amount of sodium hyaluronate and chitosan, add it to the reaction vessel, stir evenly, and obtain the reaction solution for later use;

[0056] (2) Weigh the remaining water for injection and add it to another reaction vessel, and add the auxiliary materials of the formula amount into the reaction vessel;

[0057] (3) Take the borneol of formula quantity, and after dissolving with the alcohol of 95% by volume ratio,...

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Abstract

The invention belongs to the technical field of medicines, and in particular relates to high-fidelity chitosan sodium hyaluronate eye drops and a preparation method thereof. Specifically, the high-fidelity chitosan sodium hyaluronate eye drops are prepared from the following components in percentage by weight: 0.03-0.1 wt% of chitosan, 0.1-0.3 wt% of sodium hyaluronate, 0.5wt% of an isoosmotic adjusting agent, 0.5-1.0 wt% of auxiliary material, 0.01-0.03 wt% of borneol and a pH value regulator, and the balance of water for injection. The addition quantity of the pH value regulator enables the pH value of the composition to be 6.0-9.0. The high-fidelity chitosan sodium hyaluronate eye drops intrinsically have the corrosion inhibition function, and the existing experimental data prove that the high-fidelity chitosan sodium hyaluronate eye drops have the functions of effectively preventing and treating the xerophthalmus and promoting the corneal wound healing.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a high-fidelity chitosan sodium hyaluronate eye drop and a preparation method thereof. Background technique [0002] Dry eye, keratoconjunctival sicca, refers to abnormal tear quality or quantity or abnormal dynamics caused by any reason, resulting in a decrease in the stability of the tear film, accompanied by ocular discomfort or a variety of characteristics of ocular surface tissue lesions. General term for disease. Symptoms of dry eye syndrome include dry eyes, easy fatigue, itchy eyes, foreign body sensation, burning sensation, sticky secretions, fear of wind, photophobia, sensitivity to external stimuli, etc. my country's ophthalmic drug market shows a year-by-year growth trend, and the incidence of dry eye syndrome also shows a year-by-year growth trend. According to statistics in 2009, the average prevalence of dry eye in the south of my country is 11.3%, a...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K47/36A61K31/728A61P27/04A61P27/02
Inventor 陈晚华张军东常臻吴剑英任彩霞周庆玮周晓惠
Owner SHANGHAI HAOHAI BIOLOGICAL TECH
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