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Clamping-piece-type microfluidic device and manufacturing method

A device manufacturing method and microfluidic technology, which are applied to low-cost microfluidic devices and their fast, clip-type microfluidic devices and their manufacturing processes, and the fields of batch manufacturing processes, can solve the problem of chip structure size and manufacturing stability. There are no guarantees, the structural design of microfluidic chips is limited, and the chips are difficult to manufacture in batches, etc., to achieve the effects of convenient procurement, improved application stability, and shortened processing time.

Active Publication Date: 2016-01-06
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The reason is that the existing micro-manufacturing process limits the structural design of the microfluidic chip, making the structural size and manufacturing stability of the chip unguaranteed, which makes it difficult for the chip to be stably and reliably mass-produced.

Method used

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  • Clamping-piece-type microfluidic device and manufacturing method
  • Clamping-piece-type microfluidic device and manufacturing method
  • Clamping-piece-type microfluidic device and manufacturing method

Examples

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Embodiment

[0047] A clip-type microfluidic device that can be used for high-throughput sorting devices for circulating tumor cells, such as Figure 1-5 As shown: it includes a cover plate 1 , more than one microfluidic chip assembly ( 3 ) and a bottom plate 4 arranged sequentially from top to bottom.

[0048] The cover plate 1 is provided with a sample inlet 12; the cover plate 1 is provided with a cover plate gasket groove 11, and the bottom plate 4 is provided with a bottom plate gasket groove 42; the cover plate gasket groove 11 and the bottom plate The gasket grooves 42 are provided with gaskets 2 .

[0049] The microfluidic chip assembly 3 includes a first plastic sealing film 311, a microfluidic chip 32, and a second plastic sealing film 312 arranged in sequence from top to bottom; the microfluidic chip 32 is provided with a microfluidic channel 321 and positioning Holes 322; one end of the micro-channel 321 is provided with a liquid inlet 3211, and the other end is provided with ...

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Abstract

The invention discloses a clamping-piece-type microfluidic device and a manufacturing method. The clamping-piece-type microfluidic device comprises a cover plate, sealing gaskets, a microfluidic chip assembly and a bottom plate; a sample inlet and a cover plate sealing gasket groove are formed in the cover plate; the microfluidic chip assembly is composed of a laminating film and a microfluidic chip with a microfluidic channel, and a liquid inlet hole, a liquid outlet hole and a positioning hole are formed in the microfluidic chip assembly; the bottom plate is provided with a sample outlet, a bottom plate sealing gasket groove and a positioning column; the sealing gaskets are arranged in the sealing gasket grooves formed in the cover plate and the bottom plate. The manufacturing method comprises an injection molding process method of the cover plate and the bottom plate, a laser direct writing method of the microfluidic chip, a laminating and bonding method of the microfluidic chip assembly and a hot-press assembly method of the microfluidic device. The clamping-piece-type microfluidic device is simple in structure and manufacturing method, low in cost, high in finished product rate and suitable for both one-piece making for laboratory scientific research and commercial mass production.

Description

technical field [0001] The invention relates to a clip-type microfluidic device and a manufacturing process thereof, belonging to the field of integrated microchip laboratories, in particular to a low-cost microfluidic device and a rapid and batch manufacturing process thereof. Background technique [0002] Microfluidic chip laboratory refers to the integration of macroscopic analysis operations such as sample preparation, reaction, and detection involved in the field of biochemistry into a chip, and through the manipulation and analysis of microscopic sample objects, various function of a technology. At present, microfluidic technology has been widely used in biology, chemistry, medicine and other fields. [0003] The core of the microfluidic lab-on-a-chip lies in the production of the chip. Depending on the material of the chip, different processing techniques are generally required. For example, for the production of silicon, glass and quartz chips, photolithography and...

Claims

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Application Information

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IPC IPC(8): B01L3/00
Inventor 倪中华张鑫杰项楠
Owner SOUTHEAST UNIV
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