Postoperative anti-adhesion hydrogel and preparation method thereof

Abstract

The invention discloses postoperation anti-adhesion hydrogel and a preparing method thereof. The hydrogel is prepared from sodium alginate powder, chitosan powder, acrylamide monomers, N,N'-methylene bisacrylamide, calcium sulfate, ammonium persulfate and N,N,N',N'-tetramethylethylenediamine. The preparing method of the high-strength high-tenacity chitosan and sodium alginate compound hydrogel is easy to operate, parameters are controllable, the materials are easy to obtain, and the solvent is nontoxic or low in toxicity and safe to treat and use; the method integrates advantages of the two natural biological materials, and the requirement for postoperation adhesion prevention of patients and the requirement for nursing care and treatment of medical workers can be met well. The hydrogel is soft, can be attached to the skin easily, has good flexibility and can effectively prevent wound surface adhesion and be degraded and absorbed, secondary trauma is avoided, and the hydrogel is expected to become a novel postoperation anti-adhesion material.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a medical hydrogel with postoperative anti-adhesion, antibacterial, hemostatic and healing functions and a preparation method thereof. Background technique [0002] Postoperative adhesion is one of the important medical problems to be solved urgently at home and abroad since the history of surgery. Most of the operations in the surgical field involve the prevention of adhesion between tissues. The occurrence of adhesion will not only bring pain to patients but also face high surgical expenses. Therefore, it is urgent to develop adhesion prevention materials. Under normal circumstances, the fibrous bands of connective tissue will not stick together with adjacent organs or tissues, but after surgery, due to surgical trauma, wound ischemia, foreign body presence, bleeding and exposed wound surface and bacterial infection Abnormal structures in which fibrous bands of conn...

AI Technical Summary

Problems solved by technology

[0003] At present, there are two main types of postoperative adhesion prevention materials used clinically: gel and polylactic acid: gel (sodium hyaluronate and chitosan gel) can biodegrade in vivo, but the degradation rate is too fast , the retention time in the body is too short and the gel is easy to lose, which makes the anti-adhesion effect poor; polylactic acid (L-polylactic acid, racemic polylactic acid, etc.) is currently the most widely used material in biomedical engineering, and it is also certified by the US FDA It is one of the few biological materials, but it will produce acidic degradation products during the degradation process. On the one hand, the acidic substances play an autocatalytic role, accelerate the degradation of the matrix, reduce the retention time in the body, and reduce the anti-adhesion effect. On the other hand, the accumulation of a large number of acidic products may cause non-infectious inflammation and cause certain irritation to tissues and organs.

Sodium alginate has good biocompatibility, biodegradability, hemostasis and other biological properties, and there are few reports on it as an anti-adhesion material