Method for preparing conductive polymer nano nerve conduit material

Abstract

The invention relates to a method for preparing a conductive polymer nano nerve conduit material. The method is characterized by including the following steps that firstly, PLA is dissolved in chloroform to obtain a first solution; secondly, Ppy is dissolved in a mixed solution containing lauryl sodium sulfate, methanol and water to obtain a second solution; thirdly, the first solution and the second solution are mixed, then a ferric oxide solution is added, and an oxidized polymer is obtained after oxidative polymerization; fourthly, the oxidized polymer is rinsed, deposited and dissolved, electrostatic spinning is conducted, and the conductive polymer nano nerve conduit material is obtained. By means of the method for preparing the conductive polymer nano nerve conduit material, the conductive polymer nano material can be prepared, and cell culture in vitro shows that the conductive polymer nano material can induce cell differentiation and promote cell proliferation. An electrode is implanted in a body, electrical stimulation is applied, 12 mm rat sciatic nerve defects are repaired, and a good effect is obtained.

Description

technical field [0001] The invention relates to the field of materials, in particular to the field of nanometer materials, and specifically refers to a preparation method of a conductive polymer nanometer nerve guide material. Background technique [0002] The ideal synthetic nerve guide material requires safety, tissue compatibility, degradability, permeability, suitable elasticity and mechanical strength, etc. The materials currently used mainly include biologically derived materials, non-biodegradable materials and biodegradable materials. Three categories of materials. However, none of these materials can regulate cell functions (such as adhesion, proliferation, migration, and differentiation) by electrical stimulation. In recent years, in order to achieve the purpose of regulating cell function through electrical stimulation, people have begun to apply conductive polymers in tissue engineering biotechnology, but the progress has been very limited. [0003] Therefore, ...

AI Technical Summary

Problems solved by technology

However, none of these materials can regulate cell functions (such as adhesion, proliferation, migration, and differentiation) through electrical stimulation.

In recent years, in order to achieve the purpose of regulating cell function through electrical stimulation, people have begun to apply conductive polymers in tissue engineering biotechnology, but the progress has been very limited.

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