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Medicine application of beta subunit of truncated type sodium-potassium atpase

A truncated, subunit technology, applied in the field of medicine, can solve the problems of no drugs, no research on protective effects, etc., and achieve the effect of changing nutritional deficiencies and improving hypoxia

Inactive Publication Date: 2015-12-30
THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] However, the protective effect of the truncated sodium potassium ATPase β subunit on the ischemia-reperfusion injury of islets has not yet been studied, and there are no related drugs

Method used

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  • Medicine application of beta subunit of truncated type sodium-potassium atpase
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  • Medicine application of beta subunit of truncated type sodium-potassium atpase

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Embodiment Construction

[0028] Embodiment of the present invention is described below in conjunction with accompanying drawing, embodiment does not constitute limitation of the present invention:

[0029] general idea:

[0030] prepare first tNKAβ , isolate and purify rat islet cells, simulate in vitro ischemia-reperfusion conditions, identify tNKAβ For the protection of islet cells under hypoxic conditions, starting from the activation of protein kinases in signaling pathways related to cell survival, in-depth research on the role of protein kinases such as PI3K / Akt, ERK and PKCε in ischemia-reperfusion injury of islet cells After that, SD (Sprague-Dawley) rat islet transplantation model was established to further study the activation level of the above-mentioned protein kinases and the level of ROS in ischemia-reperfusion tissue, the degree of neutrophil infiltration and various inflammatory factors The expression level relationship was verified at the level of experimental animal models tNKA...

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Abstract

The invention relates to the field of medicine, in particular to medicine application of a beta subunit of truncated type sodium-potassium atpase. The medicine application of the beta subunit of the truncated type sodium-potassium atpase on the protection effect of ischemia reperfusion injury of islet transplantation is achieved. Protection of tNKA beta on islet cell ischemia reperfusion injury is cleared, and the measure for preventing kidney ischemia reperfusion injury is further optimized. The mechanism of the tNKA beta on the protection effect on the islet cell ischemia reperfusion injury is disclosed, and a theoretical basis is provided for clinical experiments and research. The medicine application of a beta subunit of the truncated type sodium-potassium atpase has the advantages that the situation of inanition can be effectively relieved in the pancreatic islet ischemia reperfusion effect, and the anoxic situation is relieved.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the pharmaceutical use of the beta subunit of truncated sodium potassium ATPase. Background technique [0002] Ischemia-reperfusion injury is a major factor in early nonfunction and long-term survival of transplanted organs [0003] The maintenance of normal metabolism and function of tissues and organs of the body depends on good blood circulation. Ischemia of local tissues and organs caused by various reasons often causes ischemic injury to tissue cells (ischemiainjury). Ischemia-reperfusion has duality. In most cases, ischemia-reperfusion restores tissue and organ function and repairs damaged structures. But sometimes reperfusion after ischemia not only fails to restore tissue and organ function, but aggravates tissue and organ dysfunction and structural damage. This phenomenon is called ischemia-reperfusion injury (ischemia-reperfusion injury). The concept was first proposed by Jen...

Claims

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Application Information

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IPC IPC(8): A61K38/46A61P9/10C12N15/55C12N15/70C12N9/14
Inventor 郑瑾丁小明王丹薛武军田晓辉冯新顺李杨
Owner THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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