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A traditional Chinese medicine granule for treating cervical spondylosis and lumbar spondylosis and preparation method thereof

A technology of traditional Chinese medicine granules and lumbar spondylosis, which is applied in the direction of medical formulas, non-central analgesics, medical preparations of non-active ingredients, etc., which can solve the problems of storage and transportation of unfavorable shaped medicines, increased daily dosage of patients, unfavorable patients, etc. problems, to achieve the effect of high pass rate, reduced dosage, and lower daily dosage

Active Publication Date: 2019-06-07
JIANGSU HONGHUI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Usually the dry extract powder of Chinese herbal medicines has fine particle size and strong hygroscopicity, and there will be different degrees of sticking and agglomeration during the granulation process. It is necessary to add 2-3 times the amount of dry extract powder as an auxiliary material to barely make qualified granules. The patient's daily dosage is greatly increased, which is not conducive to the patient's taking
In addition, due to the strong hygroscopicity of the dry extract powder, the generally made traditional Chinese medicine granules also have strong hygroscopicity and poor stability, which is not conducive to the storage and transportation of shaped medicines.

Method used

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  • A traditional Chinese medicine granule for treating cervical spondylosis and lumbar spondylosis and preparation method thereof
  • A traditional Chinese medicine granule for treating cervical spondylosis and lumbar spondylosis and preparation method thereof
  • A traditional Chinese medicine granule for treating cervical spondylosis and lumbar spondylosis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

25.2

[0031] Preparation of extract granules: pass dry extract powder and diluent dextrin through a 60-mesh sieve, mix, add the first wetting agent ethanol, wet mix and granulate for 2 minutes, then add the second wetting agent purified water, continue to wet Mix and granulate for 2 minutes to obtain wet-mixed soft materials, granulate the obtained soft materials with a swing granulator, and dry to obtain extract granules;

[0032] Preparation of volatile oil clathrate: Weigh β-cyclodextrin and place it in a round-bottomed flask, add appropriate amount of water, heat and stir evenly to form a saturated solution; weigh volatile oil and add an equal weight of absolute ethanol to mix well , slowly added dropwise to the saturated solution of β-cyclodextrin, stirred for 8 hours, cooled to room temperature, refrigerated for 24 hours, filtered with suction, washed, dried in vacuum, crushed through a 80-mesh sieve to obtain the volatile oil clathrate;

[0033] Total blending: a...

Embodiment 2

16.8

[0036] Preparation of extract granules: pass dry extract powder and diluent dextrin through a 60-mesh sieve, mix, add the first wetting agent ethanol, wet mix and granulate for 1 minute, then add the second wetting agent purified water, continue to wet Mix and granulate for 1 minute to obtain wet-mixed soft materials, granulate the obtained soft materials with a swing granulator, and dry to obtain extract granules;

[0037] Preparation of volatile oil clathrate: Weigh β-cyclodextrin and place it in a round-bottomed flask, add appropriate amount of water, heat and stir evenly to form a saturated solution; weigh volatile oil and add an equal weight of absolute ethanol to mix well , slowly added dropwise to the saturated solution of β-cyclodextrin, stirred for 6 hours, cooled to room temperature, refrigerated for 12 hours, filtered with suction, washed, dried in vacuum, crushed through a 80-mesh sieve to obtain the volatile oil clathrate;

[0038] Total mixing: add t...

Embodiment 3

[0041] β-cyclodextrin

21

[0042] Preparation of extract granules: pass dry extract powder and diluent dextrin through a 60-mesh sieve, mix, add the first wetting agent ethanol, wet mix and granulate for 3 minutes, then add the second wetting agent purified water, continue to wet Mix and granulate for 4 minutes to obtain wet-mixed soft materials, granulate the obtained soft materials with a swing granulator, and dry to obtain extract granules;

[0043] Preparation of volatile oil clathrate: Weigh β-cyclodextrin and place it in a round-bottomed flask, add appropriate amount of water, heat and stir evenly to form a saturated solution; weigh volatile oil and add an equal weight of absolute ethanol to mix well , slowly added dropwise to the saturated solution of β-cyclodextrin, stirred and reacted for 10 hours, cooled to room temperature, refrigerated for 18 hours, suction filtered, washed, dried in vacuum, crushed through a 80-mesh sieve to obtain the inclusion c...

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Abstract

The invention discloses a traditional Chinese medicine drug granule for treating cervical spondylosis and lumbar spondylosis and a preparation method thereof. The traditional Chinese medicine drug granule is prepared from extract particles and volatile oil clathrate compounds. The extract particles include dry extract powder, diluent and wetting agents. The volatile oil clathrate compounds include volatile oil and clathration materials. The weight ratio of the dry extract powder to the diluent in the extract particles is 1 to 0.3-1.0. The obtained traditional Chinese medicine drug granule is high in percent of pass, small in auxiliary material dosage, high in stability, suitable for transportation and storage in industrial production and capable of being conveniently taken by patients.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine granule for treating cervical spondylosis and lumbar spondylosis and a preparation method thereof. Background technique [0002] Cervical spondylosis refers to the degeneration of cervical intervertebral disc, hypertrophy and hyperplasia of cervical spine, and cervical injury, which cause cervical bone hyperplasia, or intervertebral disc prolapse, ligament thickening, stimulation or compression of cervical spinal cord, cervical nerves, and blood vessels, resulting in a series of clinical symptoms. Syndrome, is a common clinical disease, frequently-occurring disease, more common in adults over the age of 40. Clinically, the main manifestations are headache, dizziness, neck and shoulder pain that can radiate to the headrest and upper limbs, neck stiffness, limited movement, heaviness on one side of the shoulder and ba...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K36/71A61K36/66A61K47/69A61P19/08A61P29/00A61K35/64
Inventor 秦勇徐成康振华王琦游剑蔡雄徐晓军
Owner JIANGSU HONGHUI PHARM CO LTD
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