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Sampling device

A sample and sample collection technology, applied in application, diagnostic recording/measurement, inoculation and ovulation diagnosis, etc., can solve the problems of pain and anxiety, expensive and time-consuming of the examinee

Active Publication Date: 2015-11-11
MARS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Samples of gastrointestinal material are often obtained using a cannulated mechanical device such as an endoscope, which is expensive, time-consuming, and causes distress and anxiety to the subject

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0107] passive drive mechanism

[0108] The spring-loaded capsules are held together by Eudragit L-100 (pH6.0) +\- cellulose wrap (to spread the load force).

[0109] Capsules were placed in gastric acid simulated solution (pH 1) for a period of 24 hours, followed by time assessment of actuation after the pH of the solution was adjusted to 7.0 using bicarbonate. Dissolution of enteric coatings appears to be highly variable.

[0110] The results obtained from different coatings at different time intervals are detailed in Table 1 below.

[0111] Table 1

[0112]

Embodiment 2

[0114] active drive mechanism

[0115] The capped sampler was compressed and placed in the solution, and released after 10 minutes, the exterior of the unit was cleaned and weighed to determine the amount of sample captured.

[0116] Alternatively, a capped sampler with an internal spring and inlet restriction (without polyacrylamide beads) was compressed and placed in solutions of different viscosities and allowed to stretch for 1 min. The contents were weighed to assess the amount of sample captured.

[0117] Table 2 below shows the volumes obtained, where the spring used was shown to be strong enough to introduce a liquid representing physiological viscosity into the sampling chamber.

[0118] Table 2

[0119] the spring

Embodiment 3

[0121] gastric emptying time

[0122] The following study investigated the measurement of normal gastric emptying time and gastrointestinal transit in Labrador retrievers using barium meal and observation with X-ray fluoroscopy.

[0123] The study group consisted of 6 adult Labrador Retrievers. Each dog was orally given a meal containing inert labeled barium sulfate (standard Boro with Tripe ( ) wet food), which was given three times during the 3-week test period. Dogs were fed 50% of their daily maintenance energy ration mixed with barium sulfate at a concentration of 7% by weight. Twelve fluoroscopy examinations were then performed on each dog on each assessment day to determine gastric emptying and intestinal transit of meals. These fluoroscopic examinations were performed at +0 minutes, +5 minutes, +15 minutes and +30 minutes after the barium meal was administered, followed by +1, +2, 3, 4, 5, 6, 7 and 8 hours. House dogs individually between fluoroscopy procedure...

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PUM

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Abstract

The present invention relates to a device for sampling internal substance(s) in the gastrointestinal tract of an animal composed of at least one wall which is partially expandable. The invention also relates to a method of orally administering the device to an animal and recovering the device from the stool to carry out analysis on the collected sample for diagnosing the health of the gastrointestinal tract and determining nutrient absorption and digestibility.

Description

technical field [0001] The present invention relates to a device for sampling one or more internal substances in the gastrointestinal tract of an animal, the device comprising at least one partially expandable wall. The invention also relates to a method of orally administering the device to an animal and recovering the device from feces to analyze the collected samples for diagnosing the health of the gastrointestinal tract and determining nutrient absorption and digestibility. Background technique [0002] The ability to directly sample material in an animal's GI tract is key for diagnosing GI tract health, determining in vivo ileal protein digestibility, and for studying the relationship between specific dietary components and chemical and physicochemical properties in an animal's GI tract enabling technology. This includes nutrient absorption, drug metabolism, microbial distribution, and more. [0003] Analysis of samples of material from the gastrointestinal tract of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/07A61B5/00A61B10/00A61B10/02
CPCA61B5/6861A61B5/073A61B5/14507A61B10/0038A61B10/0045A61B10/02A61B10/0283A61B2010/0061A61B2017/00035A61B2017/00084A61B2017/00411A61B2017/00734A61B2017/00818A61B2010/0083A61B2010/0208A61B5/14539A61B2503/40A61B2560/0214A61B2562/162
Inventor D·里格尔斯沃思T·麦克奈特
Owner MARS INC
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