Prediction method for veterinary drug residue concentration in tissue of domestic rabbit

A prediction method and organizational technology, applied in biological testing, material inspection products, special data processing applications, etc., can solve problems such as increasing the risk of veterinary drug residues

Inactive Publication Date: 2015-11-11
HENAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in the breeding process, some veterinary drugs are often used to prevent common diseases in rabbits, which not only improves the production performance of rabbits, but also increases the risk of veterinary drug residues in rabbit tissues

Method used

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  • Prediction method for veterinary drug residue concentration in tissue of domestic rabbit
  • Prediction method for veterinary drug residue concentration in tissue of domestic rabbit
  • Prediction method for veterinary drug residue concentration in tissue of domestic rabbit

Examples

Experimental program
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Effect test

Embodiment 1

[0093] In this example, Obifloxacin was taken as an example to predict the residual concentration of the drug in various tissues of rabbits after a single intramuscular injection. Obifloxacin is a small molecular substance, and during its distribution in animals, the blood flow of various tissues and organs is the main rate-limiting factor, that is, the physiological pharmacokinetic model established in the present invention is a blood flow rate-limiting type. For rabbits, muscle is the most important edible tissue, liver and kidney are the main organs for clearing orbifloxacin, and lung is the intermediate pathway connecting venous blood and arterial blood. In addition to the above tissues and organs, This model combines all other tissues into one virtual compartment of all other tissues. In addition, in order to facilitate the simulation of oral drug delivery, two modules of the stomach and intestinal tract are added to the model. Similarly, in order to facilitate the simulat...

Embodiment 2

[0120] The dosing regimen in Example 1 was changed to: three consecutive intravenous injections, with a dosing interval of 24 hours, and each dosing dose was 10 mg / kgbw. The rest of the conditions and modeling steps were the same as in Example 1. After using the acsl software to build the model, run the model to obtain the curves of the concentration of orbifloxacin in various tissues over time, as shown in Figure 8 and Figure 9 As shown, the concentration of orbifloxacin in muscle, liver, kidney, lung and plasma was predicted after three consecutive intravenous injections of orbifloxacin in rabbits.

Embodiment 3

[0122] The dosing regimen in Example 1 was changed to: three consecutive oral administrations, the dosing interval was 24 hours, and the dosage for each administration was 10 mg / kgbw. The rest of the conditions and modeling steps were the same as in Example 1. After using the acsl software to build the model, run the model to obtain the curves of the concentration of orbifloxacin in each tissue as a function of time, such as Figure 10 and Figure 11 As shown, the predicted concentration of orbifloxacin in kidney, liver, lung, muscle and plasma after three consecutive oral administration of orbifloxacin to rabbits.

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Abstract

The invention relates to a prediction method for veterinary drug residue concentration in tissue of a domestic rabbit. According to the method, physiology and anatomy parameters of the domestic rabbit are collected from existing documentations, and an area method is utilized for comparing and calculating to obtain tissue-plasma distribution coefficients of drugs in the livers, the kidneys, the muscles and the lungs of the domestic rabbit; tissue-plasma distribution coefficients of the drugs in all other pieces of tissue are obtained through parameter optimization; a parameter optimizing method is utilized for obtaining other parameters in a model; differential equations representing drug concentration in the tissue and drug mass in content of each section of the digestive tract changing along with time are written according to the mass balance principle and compiled with acsl languages, all the parameters are defined and assigned, dosage regimen parameters and model operating parameters are determined, and the model is set up. The model is operated later, and the drug residue concentration in each piece of tissue at different time points after the domestic rabbit takes the drugs according to different dosage regimens is obtained. The method can reduce test cost and workloads, and is convenient to operate, and the prediction result is accurate.

Description

technical field [0001] The invention relates to a method for predicting the residual concentration of veterinary drugs, in particular to a method for predicting the residual concentration of veterinary drugs in rabbit tissues. Background technique [0002] With the improvement of residents' living standards, consumers are paying more and more attention to the safety of animal food, and veterinary drug residues are the most important factor that endangers the safety of animal food. Long-term intake of veterinary drugs remaining in animal foods will not only cause direct harm such as allergic reactions to consumers, but some drugs also have hormone-like effects, which can lead to premature puberty in children and cause reproductive and developmental disorders; in addition, long-term intake of low-residue A large amount of antibiotics can also lead to the problem of bacterial resistance, making it difficult to treat human diseases. Therefore, if the residual concentration of v...

Claims

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Application Information

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IPC IPC(8): G01N33/48G06F19/00
Inventor 杨帆利光辉周变华孔涛王国永赵振升郝雪琴
Owner HENAN UNIV OF SCI & TECH
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