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Application of excreted factor GREM2 to 2-type diabetic therapy drug preparation

A technology for type 2 diabetes and secreted factors, which can be applied in drug combinations, medical preparations containing active ingredients, metabolic diseases, etc., and can solve problems such as blood sugar regulation without involvement

Active Publication Date: 2015-11-11
RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Little is known about the biological function of GREM2, especially in blood glucose regulation

Method used

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  • Application of excreted factor GREM2 to 2-type diabetic therapy drug preparation
  • Application of excreted factor GREM2 to 2-type diabetic therapy drug preparation
  • Application of excreted factor GREM2 to 2-type diabetic therapy drug preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0018] 1. The blood glucose of GREM2 transgenic mice was significantly improved

[0019] 1) Establishment of a mouse model of systemic overexpression of GREM2.

[0020] Using C57BL / 6J mice as the background, we experienced vector construction, DNA linearization and purification, linearized DNA microinjection into 200 fertilized eggs, and these fertilized eggs were returned to the fallopian tubes of 3-4 surrogate mother mice. Finally, 10 founder mice (Founders) with positive genotype results were obtained through PCR identification, and three unusable founders were removed: GAfounders gave birth to the F1 generation, and no longer gave birth; GEfounders did not give birth to positive mice; GJfounders had a positive fertility rate Low, there are not enough mice for identification, and the overexpression efficiency of the remaining 7 founders is as follows figure 1 As shown, after the expression efficiency identification, the overexpression efficiency of GF mice is higher, which...

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Abstract

The invention belongs to the technical field of drug preparation, and particularly relates to an application of an excreted factor GREM2 to 2-type diabetic therapy drug preparation. The research proves that a GREM2 transgenic mouse has obviously improved sugar tolerance and obviously increased insulin sensitivity. Further experiments show that a hepatic insulin downstream P-AKT signal path of the transgenic mouse is remarkably enhanced, prompting that the hepatic insulin sensitivity is increased. An ob diabetic mouse model is used to find that after adenovirus overexpression GREM2 protein is given to an ob mouse, blood glucose is obviously improved, fatty liver is obviously improved, and insulin sensitivity is remarkably increased. Therefore, the GREM2 can be applied to preparation of sugar-reducing drugs and drugs for improving 2-type diabetes, and provides a new drug target for clinically curing the 2-type diabetes.

Description

technical field [0001] The technical field of medicine preparation of the present invention particularly relates to the application of secreted factor GREM2 in the preparation of medicines for treating type 2 diabetes. Background technique [0002] Diabetes mellitus is a clinical syndrome characterized by hyperglycemia. Type 2 diabetes accounts for more than 95% of the total diabetes population. Diabetes has become a global health problem. Up to now, there are more than 171 million diabetics in the world. According to statistics, by 2030, the number of diabetics worldwide will exceed 370 million. The number of patients with diabetes in our country is increasing rapidly. How to effectively treat diabetes is an urgent problem and research hotspot for researchers. [0003] The seriousness of diabetes lies in the various acute and chronic complications caused by chronic hyperglycemia. Complications mainly include diabetic heart, brain, peripheral vascular disease, diabetic ne...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/19A61P3/10
Inventor 宁光洪洁王计秋刘瑞欣杨明兰
Owner RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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