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Preparation method of carboxylated nano-crystal cellulose enhanced calcium phosphate support

A nanocrystal, carboxylation technology, applied in the direction of prosthesis, medical science, etc., can solve the problem of incompatibility with mechanical strength, biocompatibility and biodegradability, increase the probability of infection of patients, pain and economic burden of secondary surgery, It is difficult to obtain monodisperse fibers, etc., to achieve the effects of good biodegradability, avoidance of damage and burden, and simple steps

Inactive Publication Date: 2015-11-04
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these enhancers lack excellent biocompatibility, will not degrade in the human body, will remain in the body after implantation, and will have adverse effects on humans. Surgical Pain and Financial Burden
CN201410137741.4 discloses an electrospun fiber-reinforced calcium phosphate bone cement composite material and its application, which improves the initial compressive strength of CPC, and degrades the electrospun fiber later, which increases the porosity of CPC, which is beneficial to the growth of tissues , but the fiber preparation process is more complicated, and it is difficult to obtain monodisperse fibers, and the agglomerated fibers are likely to cause stress concentration in CPC
The compressive strength of the enhanced CaP-S prepared by the existing preparation method is generally below 40 MPa, and it is not compatible with the characteristics required by the scaffold such as mechanical strength, biocompatibility and biodegradability

Method used

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  • Preparation method of carboxylated nano-crystal cellulose enhanced calcium phosphate support
  • Preparation method of carboxylated nano-crystal cellulose enhanced calcium phosphate support
  • Preparation method of carboxylated nano-crystal cellulose enhanced calcium phosphate support

Examples

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Embodiment 1

[0048] A preparation method of carboxylated nanocrystalline cellulose reinforced calcium phosphate scaffold, the steps are:

[0049] A. Nanocrystalline cellulose carboxylation modification

[0050] A1, adding nanocrystalline cellulose to deionized water to prepare a suspension of nanocrystalline cellulose with a concentration of 1wt.%.

[0051] A2. Add 0.18 parts by weight of NaBr and 0.07 parts by weight of 2,2,6,6-tetramethylpiperidine-1-oxide to 100 parts by weight of nanocrystalline cellulose suspension. After stirring and dissolving, add 40 The concentration of part weight is the NaClO solution of 12wt.% and constantly stirs, adjusts the pH value of solution with the NaOH solution of 0.5mol / L in the stirring process, makes pH value stable at 10.5; Then adds 40 parts of heavy dehydrated alcohol, obtains Dispersions;

[0052] A3. Adjust the pH value of the dispersion in step A2 to 3.0 with 0.5 mol / L HCl, and let it stand for 24 hours; centrifuge, wash and use a dialysis b...

Embodiment 2

[0072] A preparation method of carboxylated nanocrystalline cellulose reinforced calcium phosphate scaffold, the steps are:

[0073] A. Nanocrystalline cellulose carboxylation modification

[0074] A1, adding nanocrystalline cellulose to deionized water to prepare a suspension of nanocrystalline cellulose with a concentration of 0.5wt.%.

[0075] A2, add 0.1 part by weight of NaBr and 0.01 part by weight of 2,2,6,6-tetramethylpiperidine-1-oxide to 100 parts by weight of nanocrystalline cellulose suspension, stir and dissolve, then add 10 The concentration of part weight is 5wt.% NaClO solution and is constantly stirred, and the pH value of solution is adjusted with the KOH solution of 0.1mol / L in the stirring process, makes pH value be stable at 9.0; Then add 10 parts of heavy dehydrated alcohol, obtain Dispersions;

[0076] A3, use 0.1mol / L of H 2 SO 4 Solution Adjust the pH value of the dispersion in step A2 to 2.5, and let it stand for 36 hours; centrifuge, wash, and use ...

Embodiment 3

[0084] A preparation method of carboxylated nanocrystalline cellulose reinforced calcium phosphate scaffold, the steps are:

[0085] A. Nanocrystalline cellulose carboxylation modification

[0086] A1, adding nanocrystalline cellulose to deionized water to prepare a suspension of nanocrystalline cellulose with a concentration of 5wt.%.

[0087] A2. Add 10 parts by weight of NaBr and 0.5 parts by weight of 2,2,6,6-tetramethylpiperidine-1-oxide to 100 parts by weight of nanocrystalline cellulose suspension, stir and dissolve, then add 60 The concentration of part weight is the NaClO solution of 14wt.% and is constantly stirred, and the pH value of solution is adjusted with the NaOH solution of 1mol / L in the stirring process, makes pH value be stable at 11.5; liquid;

[0088] A3. Use 1.0mol / L HCl to adjust the pH value of the dispersion in step A2 to 3.0, and let it stand for 24h; centrifuge, wash and use a dialysis bag to filter out small molecular substances with a molecular ...

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Abstract

The invention relates to a preparation method of a carboxylated nano-crystal cellulose enhanced calcium phosphate support, which comprises the following steps: A)performing carboxylating modification on nano-crystal cellulose to obtain a carboxylated nano-crystal cellulose fluid suspension; B)preparation of composite powder: adding soluble calcium salt and a soluble phosphatic solution according to mol ratio of Ca and P being 1.67: 1 in order in the carboxylated nano-crystal cellulose fluid suspension; performing in situ synthesis to obtain hydroxyapatite in the carboxylated nano-crystal cellulose fluid suspension, washing, performing pumping filtration, and drying to obtain the carboxylated nano-crystal cellulose hydroxyapatite composite powder; and C)preparation of the support: individually taking the carboxylated nano-crystal cellulose hydroxyapatite composite powder as support solid phase powder, or uniformly mixing with other calcium salt powder to obtain the product being as the support solid phase powder; adding a support moulding liquid, and performing water-bath solidifying after moulding to obtain the product. The carboxylated nano-crystal cellulose enhanced calcium phosphate support has high compressive strength.

Description

technical field [0001] The invention relates to a calcium phosphate support, in particular to the preparation of a carboxylated nanocrystalline cellulose reinforced calcium phosphate support, which belongs to the field of composite materials. Background technique [0002] Calcium phosphate scaffold (CaP-S) refers to bone scaffolds prepared from calcium phosphate materials (calcium hydrogen phosphate, tetracalcium phosphate powder, α-tricalcium phosphate, β-tricalcium phosphate, hydroxyapatite, etc.). Tissue engineering scaffolds, with good biocompatibility and biodegradability, have been used as clinical bone repair materials. However, CaP-S is an inorganic non-metallic material, which is brittle and has low mechanical strength. For example, its compressive strength is only equivalent to that of cancellous bone, which limits its clinical application. Therefore, it is necessary to improve the mechanical strength of CaP-S to meet the clinical requirements for the mechanical s...

Claims

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Application Information

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IPC IPC(8): A61L27/42A61L27/50
Inventor 屈树新赵军胜刘宗光李鹏刘玉梅黄萍冯波翁杰
Owner SOUTHWEST JIAOTONG UNIV
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