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Composition containing kirenol and application thereof in medicament

A technology of kinonanol and composition, which is applied in the field of kinonanol-containing compositions, and can solve problems such as unclear quality control indicators, difficulty in industrialization, and unclear chemical composition

Active Publication Date: 2015-11-04
SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The medicine disclosed in patent CN200710170657.2 is also difficult to industrialize due to problems such as unclear chemical composition and unclear quality control indicators.

Method used

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  • Composition containing kirenol and application thereof in medicament
  • Composition containing kirenol and application thereof in medicament
  • Composition containing kirenol and application thereof in medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Get the dry Sisia chinensis leaves, pulverize, add 10 times (weight) 95% ethanol to reflux and extract twice, each time for 1.0 hour, filter, combine the filtrates, concentrate to a solution with a relative density of 1.05 to 1.15 when concentrated to 50°C, filter The processed macroporous adsorption resin column collects 25% to 80% ethanol eluted fractions, concentrates and recovers ethanol, and continues to concentrate to an extract with a relative density of 1.10 to 1.20 at 50°C, and vacuum-dries to obtain Siberia chinensis leaves of extracts.

[0017] Dissolve the extracts of the leaves of Westerus chinensis with 10 times the weight of petroleum ether-ethyl acetate (1:1), put them on the treated silica gel chromatography column, and use 10 times the column volume of the eluent (petroleum ether ethyl acetate Equal volume mixing) eluting, collect eluate in sections, collect the elution fraction of quinonyl alcohol and the elution fraction of quinnonyl alcohol, concent...

Embodiment 2

[0025] Compositions ①, ②, ③ and ④ containing chinonyl alcohol prepared by the examples;

[0026] Anti-delayed hypersensitivity effect in mice

[0027] Healthy ICR mice were taken, weighing 20-22 g, male. Divided into 10 groups at random, 12 in each group, respectively A group: blank control group (distilled water group),

[0028] Group B: positive control group (dexamethasone group),

[0029] Group C: the composition group containing kinonyl alcohol (kinonyl alcohol: kaurin alcohol = 1:0.02 mixture)

[0030] Group D: kinonyl alcohol-containing composition group (kinonyl alcohol: bracken alcohol = 1:0.05 mixture)

[0031] Group E: kinonyl alcohol-containing composition group (kinonyl alcohol: bracken alcohol = 1:0.2 mixture)

[0032] Group F: the composition group containing kinonyl alcohol (kinonyl alcohol: kaurin alcohol = 1:0.5 mixture)

[0033] Group G: kinonyl alcohol-containing composition group (kinonyl alcohol: bracken alcohol = 1:0.8 mixture)

[0034] Group H: ki...

Embodiment 3

[0043] The dry product of chiren alcohol obtained in Example 1 and the dried product of kaurin alcohol are mixed uniformly according to the following ratio

[0044] ①Kinnonyl alcohol: chinonyl alcohol=1:0.4 mixed to obtain a composition containing chinonyl alcohol;

[0045] ②Kinonyl alcohol: chinonyl alcohol=1:0.8 mixed to obtain a composition containing chinonyl alcohol;

[0046] ③Kinnonyl alcohol: chinonyl alcohol=1:0.05 mixed to obtain a composition containing chinonyl alcohol;

[0047] ④Kinnonyl alcohol: chinonyl alcohol=1:0.6 mixed to obtain a composition containing chinonyl alcohol;

[0048] Anti-xylene-induced ear swelling in mice

[0049] Take male mice, 18-22g, and divide them into 10 groups at random, 12 in each group, which are respectively Group A: blank control group (distilled water group),

[0050] Group B: positive control group (compound Danshen group),

[0051] Group C: the composition group containing kinonyl alcohol (kinonyl alcohol: kaurin alcohol = 1:...

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Abstract

The invention discloses composition containing kirenol and the application of the composition in medicament. The composition containing the kirenol is characterized by being formed by the kirenol and darutigenol, wherein the weight ratio of the kirenol and the darutigenol is 1 to (0.05 to 0.8). The composition containing the kirenol, disclosed by the invention, has a remarkable treating effect on gouty arthritis, rheumatic arthritis and rheumatoid arthritis, is used for preparing medicines which can be used for treating the gouty arthritis, the rheumatic arthritis and the rheumatoid arthritis, has the advantages of remarkable arthritis resisting function, clear chemical component and clear quality control index, is safe and effective, is clear in ingredient and provides a novel means for treating diseases such as arthritis and gout.

Description

technical field [0001] The invention relates to a composition containing kinonanol, in particular to a composition containing chinonanol for treating gout, rheumatism and rheumatoid arthritis. Background technique [0002] Acute gout, rheumatoid arthritis, and rheumatoid arthritis are common diseases. At present, 91.7% of adults and 55.7% of children are affected by their joints in the world, and the number of disabled and dead due to their lesions It is at the forefront of the world's epidemic. The prevalence of rheumatoid arthritis is 0.3% to 1.5%, and it is more common after the age of 30. The high incidence age of females is 45 to 54 years old, and the males gradually increase with age. [0003] At present, there are many kinds of antirheumatic drugs, such as penicillamine, salicylic acid preparations, indomethacin, propionic acid derivatives, indole derivatives, immunosuppressants, antimalarials, etc. However, the side effects of Western medicines have been increasing...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/047A61P19/02A61P19/06A61P29/00
Inventor 程志红
Owner SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
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