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Dragon's blood tree leaf extract product, and preparation method, pharmaceutical composition, preparation, and applications thereof

An extract, the technology of Dracaena glabrata, applied in the field of medicine, can solve the problems of few research reports on Dracaena leaves, blank of leaf extract and its preparation method and use, no literature reports, etc.

Active Publication Date: 2015-10-28
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are many domestic and foreign research reports on the lipid-containing wood or dracaena of Dracaena dracaena, but there are fewer research reports on the leaves of Dracaena dracaena, especially in the leaf extract of dracaena dracaena and its preparation method. and use is still blank, no literature reports

Method used

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  • Dragon's blood tree leaf extract product, and preparation method, pharmaceutical composition, preparation, and applications thereof
  • Dragon's blood tree leaf extract product, and preparation method, pharmaceutical composition, preparation, and applications thereof
  • Dragon's blood tree leaf extract product, and preparation method, pharmaceutical composition, preparation, and applications thereof

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Effect test

preparation example Construction

[0027] The preparation method of the dragon and blood leaves described in the present invention is characterized by the following steps:

[0028] A. Siege the raw material dragon blood leaves, add a hydrogen phosphate di -sodium aquatic solution with a weight ratio of 10-15 times, soak at 10 ~ 30 ° C for 30 ~ 120min, and extract 4 ~ 5h at 20 ~ 30 ° C.

[0029] B. Drip and hydrochloric acid in the extraction solution neutralize and adjust the pH value to 3 ~ 5, 10 ~ 30 ° C for a static settlement and settlement of 8 ~ 48h, vacuum pump filter, washed the filtrate of the filter to the filtrate, the pH was 6.5 ~ 7.5, Draw up;

[0030] C. Add the ethanol solution with a weight ratio of 30 to 40 times in the filter after the B Step of B and extracts 2 to 4 times at 60 ~ 70 ° C. The merger of the extraction solution is added.Activated carbon, heat up to 30 ~ 40 ° C after boiling, and filter the filter liquid with 0.45 μm micropores;

[0031] D. Dry the filter fluid to get the target drag...

Embodiment 1

[0042] Example 1 Preparation of Dragon Blood Leaf Extraction 1

[0043] The base source and harvest time of medicinal materials: The dried leaves of Dracaena Cambodiana Pierre Ex Gagnep.Picked in August 2014 and dried it naturally in the sun.

[0044] Preparation:

[0045] After the dry dragon blood tree leaves are selected, it is crushed with a fragmented machine and over 50 mesh screens. It is said that the above-mentioned leaf rough powder is 10kg, and the 100 kg of 20%hydrogen phosphate di-sodium aquatic solution is added.Under the condition of 25 ° C, continuous ultrasound extraction was extracted for 5h.

[0046] The above extraction solution is filtered with a single -filament filter cloth with a model of 2815. After the filter liquid is collected, add 10%hydrochloride stirring and regulate pH to 3, the room temperature is settled by more than 8h, vacuum filtration, the filter repeatedly washing, pumping, pumping, pumping, pumping, pumping, pumping, pumping, pumpingFilterin...

Embodiment 2

[0049] Example 2 Dragon Blood Leaf Extract 2 Preparation

[0050] The base source and harvest time of medicinal materials: Dracaenchinchinensis (Lour.) S. C. Chen's dry leaves used in the Dragon Blood Leaf Blood Tree used in this experiment.Picked in July 2014 and dried it naturally in the sun.

[0051] Preparation:

[0052] After the dried dragon blood leaves are selected, it is crushed with a fragmented machine and over 50 mesh sieves.It is said that the above-mentioned leaves of the leaves are 30kg, and the 450 kg of 20%of the hydrogen phosphate di-sodium aquatic solution is added.

[0053] The above extraction solution is filtered with a single -filaments with a model of 2815. After the filter liquid is collected, add 10%hydrochloric acid stirring and regulate pH to 5, the room temperature is settled by more than 8h, vacuum filtration, the filter repeatedly washed, pumping, pumping, pumping, pumping, pumping, pumping, pumpingFiltering to the filtration liquid is neutral, dry, ...

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Abstract

The invention discloses a dragon's blood tree leaf extract product, and a preparation method, a pharmaceutical composition, a preparation, and applications thereof. According to the preparation method, the dragon's blood tree leaf extract product is prepared by taking dried leaves of Dracaena cambodiana Pierreex Gagnep. or Dracaena cochinchinensis (Lour.) S. C. Chen as raw materials; total flavones content of the dragon's blood tree leaf extract product is 1.0% or higher; and no tannin, resin, or oxalate is detected. The dragon's blood tree leaf extract product possesses excellent effects on preventing and controlling osteoporosis and reducing blood glucose, and clinical application prospect is promising. According to the preparation method, the raw materials are easily available; operation is simple; the preparation method is economical and friendly to the environment; product quality is stable and controllable; and the preparation method is suitable for industrial scale production.

Description

Technical field [0001] The present invention is the field of pharmaceutical technology, which involves a kind of dragon -blooded leaves extract and its preparation methods, its pharmaceutical compositions, preparations and applications. Background technique [0002] Dragon Blood Tree, 14 volumes of "Chinese Plants", there are about 40 species in the world, mainly distributed in tropical and subtropical regions in Asia and Africa.There are 5 kinds of dragon blood trees in my country, which are mainly distributed in Yunnan, Guangxi, Hainan, and Taiwan, namely: Hainan Dragon Blood Tree D. Cambodiana Pierre EX Gagnep, Sword Leaf Dragon Blood Tree D. Cochinchinensis (Lour.) S. C. Chen, long flower dragon blood tree d. angustifoliaaroxb., Demon Dragon Blood Tree D. Gracilis Wall. EX Baker and Dragon Blood Tree D.terniflora Roxb. [0003] Among them, after the trunk of the sword -leaf dragon blood tree was damaged and injured, the invasion and infection of the diseased sources such as t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61P19/10A61P3/10
Inventor 周荣光杨兆祥赵加强
Owner KPC PHARM INC
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