Pharmaceutical composition with dysmenorrheal-resistant efficacy and preparation method of pharmaceutical composition

A technology of composition and medicine, which is applied in the field of pharmaceutical composition with anti-dysmenorrhea effect and its preparation, can solve problems such as unclear effect substances, and achieve the effect of enhancing anti-dysmenorrhea activity

Inactive Publication Date: 2015-10-21
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

As we all know, the effect component is the material basis of traditional Chinese medicine for disease prevention and treatment. However, in the research report of Cyperus cyperi, only research shows that α-cyperone is one of the active components of Cyperus cyperus to exert antipyretic and analgesic effects, and other effect substances still unclear

Method used

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  • Pharmaceutical composition with dysmenorrheal-resistant efficacy and preparation method of pharmaceutical composition
  • Pharmaceutical composition with dysmenorrheal-resistant efficacy and preparation method of pharmaceutical composition
  • Pharmaceutical composition with dysmenorrheal-resistant efficacy and preparation method of pharmaceutical composition

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The specific steps of the preparation method of the pharmaceutical composition with anti-dysmenorrhea effect of the present invention are as follows:

[0024] (1) Extraction of monomer compound components:

[0025] Crush Cyperus cyperi from Jianchangbang Sizhi into a coarse powder, place it in a round bottom flask, add 95% ethanol in an amount 8 times the amount of Cyperus cyperus from Jianchangbang, heat and reflux for extraction 3 times, each time for 2 hours, combine the filtrates, and The organic solvent in the filtrate is recovered under reduced pressure to obtain the Cyperus cyperi extract;

[0026] (2) Separation and purification of monomer compound components:

[0027] The extract of Cyperus cyperi is extracted by petroleum ether, the type of petroleum ether is 60-90°C, and the petroleum ether part of Cyperus cyperi is obtained; the petroleum ether part of Cyperus cyperi is mixed with 1-2 times of silica gel, and evaporated to dryness After the solvent, put it...

Embodiment 2

[0031] The specific steps of the preparation method of the pharmaceutical composition with anti-dysmenorrhea effect of the present invention are as follows:

[0032] (1) Extraction of monomer compound components:

[0033] Crush Cyperus cyperi from Jianchangbang Sizhi into a coarse powder, place it in a round bottom flask, add 95% ethanol in an amount 8 times the amount of Cyperus cyperus from Jianchangbang, heat and reflux for extraction 3 times, each time for 2 hours, combine the filtrates, and The organic solvent in the filtrate is recovered under reduced pressure to obtain the Cyperus cyperi extract;

[0034] (2) Separation and purification of monomer compound components:

[0035] The extract of Cyperus cyperi is extracted with petroleum ether (60-90°C) to obtain the petroleum ether part of Cyperus cyperi; mix the petroleum ether part of Cyperus cyperi with 1-2 times the amount of silica gel, evaporate the solvent, and dry Put the method on a silica gel column, use petrol...

Embodiment 3

[0039] The specific steps of the preparation method of the pharmaceutical composition with anti-dysmenorrhea effect of the present invention are as follows:

[0040] (1) Extraction of monomer compound components:

[0041] Crush Cyperus cyperi from Jianchangbang Sizhi into a coarse powder, place it in a round bottom flask, add 95% ethanol in an amount 8 times the amount of Cyperus cyperus from Jianchangbang, heat and reflux for extraction 3 times, each time for 2 hours, combine the filtrates, and The organic solvent in the filtrate is recovered under reduced pressure to obtain the Cyperus cyperi extract;

[0042] (2) Separation and purification of monomer compound components:

[0043] The extract of Cyperus cyperi is extracted with petroleum ether (60-90°C) to obtain the petroleum ether part of Cyperus cyperi; mix the petroleum ether part of Cyperus cyperi with 1-2 times the amount of silica gel, evaporate the solvent, and dry Put the method on a silica gel column, use petrol...

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Abstract

The invention discloses a pharmaceutical composition with the dysmenorrheal-resistant efficacy and a preparation method of the pharmaceutical composition. The pharmaceutical composition is composed of three active components including cyperotundone, alpha-cyperone and sugeonol. When dysmenorrheal-resistant biological effect experiment comparison is carried out on the pharmaceutical composition prepared by the three effective compounds mixed in different proportions, the result shows that when the mass ratio of the cyperotundone to the alpha-cyperone and to the sugeonol is 43:41:16, the dysmenorrheal-resistant efficacy is remarkably enhanced. The pharmaceutical composition has the beneficial effects that the pharmaceutical composition is the optimum composition of four-method prepared rhizoma cyperi dysmenorrheal-resistant efficacy active components; and in the aspect of the active components, matching research is performed among the active components, and the dysmenorrheal-resistant biological effect of the four-method prepared rhizoma cyperi is greatly improved. Traditional Chinese medicine active component compatibility eliminates interference of non-medicine-efficacy substances, and new discovery of traditional Chinese medicine component drugs is facilitated. Various effective preparations for clinical application can be conveniently developed, and new dosage form research is facilitated.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a pharmaceutical composition with anti-dysmenorrhea effect and a preparation method thereof. Background technique [0002] Dysmenorrhea refers to periodic lower abdominal pain or lumbosacral pain during menstruation or before and after menstruation, accompanied by pale complexion, cold hands and feet, nausea and vomiting, and cold sweats. Clinically, there are mainly two kinds of primary dysmenorrhea and secondary dysmenorrhea. Primary dysmenorrhea has no obvious abnormalities in the reproductive organs, while secondary dysmenorrhea is mostly manifested as certain organic lesions of the reproductive organs. The incidence of dysmenorrhea is relatively high, about 42% to 90%, of which severe dysmenorrhea accounts for 18%, and it is more common in young women. It is one of the key diseases treated by TCM gynecology. [0003] The active ingredients of traditio...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61P15/00A61P29/00
Inventor 郭慧玲胡律江赵晓娟胡志方许茜茜
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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