Screening method of main-effect medicine components in traditional Chinese medicine compound
A drug and compound technology, which is applied in the field of screening and evaluation of the main active drug ingredients in Chinese medicine compound, can solve the problems of poor portability, too much subjectivity, and no main active drug ingredients of Chinese medicine compound.
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Embodiment 1
[0065] 1. Experimental materials
[0066] FVB / NJ mice: purchased from Shanghai Experimental Animal Research Center;
[0067] Acute promyelocytic leukemia (APL) mouse model: constructed according to literature methods;
[0068] Compound Huangdai Tablets: purchased from Guangzhou Baiji Xinte Pharmacy;
[0069] Realgar, Danshen, Qingdai: purchased from Caizhilin Pharmacy in Guangzhou;
[0070] Affymetrix GeneChip Mouse Genome4302.0Array: purchased from Shanghai Biochip Co., Ltd.;
[0071] R: open source computing platform, downloaded from R official website;
[0072] Limma analysis package: open source analysis package, downloaded from the Bioconductor website;
[0073] Protein interaction data: downloaded from the BioGRID database.
[0074] 2. Experimental method:
[0075] (1) Fifteen 6-8 week FVB / NJ mice were injected with cells expressing PML-RAR to establish a mouse model of acute promyelocytic leukemia (APL);
[0076] (2) Divide APL mice into groups of 3 each, one gro...
Embodiment 2
[0091] 1. Experimental materials
[0092] SCID mice: purchased from Guangdong Medical Experimental Animal Center;
[0093] Acute promyelocytic leukemia (APL) mouse model: constructed according to literature methods;
[0094] Compound Huangdai Tablets: purchased from Guangzhou Baiji Xinte Pharmacy;
[0095] Realgar, Danshen, Qingdai: purchased from Caizhilin Pharmacy in Guangzhou;
[0096] Illumina MouseRef-8v2.0expression beadchip: purchased from Shanghai Biochip Co., Ltd.;
[0097] R: open source computing platform, downloaded from R official website;
[0098] Limma analysis package: open source analysis package, downloaded from the Bioconductor website;
[0099] Protein interaction data: download from BioGRID database;
[0100] 2. Experimental method
[0101](1) 15 6-8 week SCID mice were injected with cells expressing PML-RAR to establish a mouse model of acute promyelocytic leukemia (APL);
[0102] (2) Divide APL mice into groups of 3 each, one group is used as APL ...
Embodiment 3
[0117] 1. Experimental materials
[0118] BABL / c mice: purchased from Guangdong Medical Experimental Animal Center;
[0119] Acute promyelocytic leukemia (APL) mouse model: constructed according to literature methods;
[0120] Compound Huangdai Tablets: purchased from Guangzhou Baiji Xinte Pharmacy;
[0121] Realgar, Danshen, Qingdai: purchased from Caizhilin Pharmacy in Guangzhou;
[0122] Agilent-014868Whole Mouse Genome Microarray4x44K G4122F: purchased from Shanghai Biochip Co., Ltd.;
[0123] R: open source computing platform, downloaded from R official website;
[0124] Limma analysis package: open source analysis package, downloaded from the Bioconductor website;
[0125] Protein interaction data: download from BioGRID database;
[0126] 2. Experimental method
[0127] (1) Fifteen BABL / c mice at 6-8 weeks were injected with cells expressing PML-RAR to establish a mouse model of acute promyelocytic leukemia (APL);
[0128] (2) Divide APL mice into groups of 3 each...
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