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New uses of Carya cathayensis leaf extract in preparation of estrogen drugs

A technology of pecan leaves and extracts is applied in the directions of drug combinations, anti-tumor drugs, pharmaceutical formulations, etc., to achieve the effect of good utilization and expansion of application scope.

Active Publication Date: 2015-10-14
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The prior art has not yet seen the effect of hickory leaf extract, especially its monomer chemical composition, on phytoestrogens

Method used

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  • New uses of Carya cathayensis leaf extract in preparation of estrogen drugs
  • New uses of Carya cathayensis leaf extract in preparation of estrogen drugs
  • New uses of Carya cathayensis leaf extract in preparation of estrogen drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0021] 1. Using MCF-7 (ER+) and MDA-MB-231 (ER-) to carry out experiments, the hickory leaf extract and five main chemical components (chrysin, ballocchinin, chalcone, cardamonin, and baicalein and pinusin) for the detection of phytoestrogen activity.

[0022] 1. Drugs and cell lines (cardamonin, Beijing Century Aoke Biotechnology Co., Ltd., batch number: 110763; wogonin, Beijing Century Aoke Biotechnology Co., Ltd., batch number: 11040501; chrysin, Beijing Century Aoke Biotechnology Co., Ltd. Co., Ltd., batch number: 11103007; conchapinin chalcone and pinusin, provided by the School of Life Sciences, Zhejiang University of Traditional Chinese Medicine, commercially available; 17β‐estradiol, Dr. Ehrenstorfer, batch number: 50‐28‐2; soybean iso Flavonoids, spring and autumn, batch number: 574-12-9; genistein, Beijing Century Aoke Biotechnology Co., Ltd., batch number: 13010801; hickory leaf extract is prepared according to the method of CN103142685B) hickory leaf extract ( Fl)...

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Abstract

The present invention discloses new uses of a Carya cathayensis leaf extract in preparation of estrogen drugs, wherein the Carya cathayensis leaf extract is used for preparing drugs for treatment and / or prevention of mammalian estrogen hyposecretion related diseases. According to the present invention, the Carya cathayensis leaf can be well utilized, the waste can be changed into treasure, and the application range of the Carya cathayensis leaf extract is broadened.

Description

technical field [0001] The invention relates to a new application of hickory leaf extract, in particular to a new application of hickory leaf extract in preparing estrogen medicine. Background technique [0002] After women enter menopause, due to the decline of ovarian function and the decrease of estrogen secretion, various physiological processes mediated by estrogen will be affected, which will not only lead to a series of symptoms of nervous system dysfunction, but also may cause coronary heart disease, atherosclerosis, etc. diseases such as sclerosis and osteoporosis. In order to treat and / or prevent the above-mentioned diseases, estrogen replacement therapy has become the most commonly used clinical method, but clinical practice over the years has shown that long-term use of estrogen will greatly increase the incidence of breast cancer. Therefore, it is necessary to find a safe and Effective phytoestrogens are currently a major topic in the pharmaceutical community. ...

Claims

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Application Information

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IPC IPC(8): A61K36/52A61P5/30A61P19/10A61P19/08A61P19/04A61P1/02A61P15/00A61P3/06A61P9/00A61P25/28A61P3/04A61P13/00A61P1/00A61P9/12A61P9/10A61P35/00A61K31/352A61K31/12
Inventor 丁志山钱朝东黄燕芬吕敏蒋福升金波周芳美丁滨刘彩霞
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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