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Pleurotus citrinopileatus Singer polysaccharide protein compound, preparation method and use thereof

A technology of Pleurotus chinensis and polysaccharide protein, which is applied in the field of natural drug development, can solve the problems that have not been discovered in the development, achieve significant muscle atrophy and improve the effect of muscle atrophy

Inactive Publication Date: 2015-09-30
JILIN AGRICULTURAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Other medicinal uses have not yet been discovered

Method used

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  • Pleurotus citrinopileatus Singer polysaccharide protein compound, preparation method and use thereof
  • Pleurotus citrinopileatus Singer polysaccharide protein compound, preparation method and use thereof
  • Pleurotus citrinopileatus Singer polysaccharide protein compound, preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Include the following steps:

[0016] Select clean fruiting bodies of Pleurotus aureus, dry, crush, and extract in hot water for 4 hours according to the mass-volume ratio of material to liquid at 1:20, extract twice, combine the extracts, filter them into a beaker with gauze, and concentrate under reduced pressure. Add 4 times the volume of 85% ethanol, precipitate in the refrigerator at 4°C for 12 hours, collect the precipitate by centrifugation, and freeze-dry.

Embodiment 2

[0018] Include the following steps:

[0019] Select clean fruiting bodies of Pleurotus aureus, dry, crush, and extract in hot water for 5 hours according to the mass-volume ratio of material to liquid at 1:25, and extract 3 times. Combine the extracts, filter them into a beaker with gauze, and concentrate under reduced pressure. Add 5 times the volume of 85% ethanol, precipitate in the refrigerator at 4°C for 14 hours, collect the precipitate by centrifugation, and freeze-dry.

Embodiment 3

[0021] Include the following steps:

[0022] Select clean fruiting bodies of Pleurotus aureus, dry, crush, and extract in hot water for 6 hours according to the mass-volume ratio of material to liquid at 1:30, extract 3 times, combine the extracts, filter them into a beaker with gauze, and concentrate under reduced pressure. Add 6 times the volume of 85% ethanol, precipitate in the refrigerator at 4°C for 16 hours, collect the precipitate by centrifugation, and freeze-dry.

[0023] Next, the effects of the present invention will be further illustrated by specific test examples.

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PUM

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Abstract

Belonging to the field of natural drug development, the invention relates to a Pleurotus citrinopileatus Singer polysaccharide protein compound, a preparation method and use thereof. The preparation method includes: selecting clean Pleurotus citrinopileatus Singer fruiting body, conducting drying and crushing, according to a material-liquid mass-liquid ratio of 1:20-30, performing hot water extraction for 4-6h 2-3 times, merging the extracted liquid, conducting gauze filtering into a beaker, carrying out vacuum concentration, then adding 4-6 times volume of 85% ethanol, conducting precipitation in 4DEG C refrigerator for 12-16h, performing centrifugation and collecting the precipitate, and conducting freeze drying. According to the invention, a new polysaccharide protein compound is obtained from the Pleurotus citrinopileatus Singer fruiting body, the compound has the effect of improving tail suspension caused rat muscle atrophy, and has significant resistance effect on mouse hindlimb muscle atrophy. The invention provides important research basis for medicinal value development of Pleurotus citrinopileatus Singer.

Description

technical field [0001] The invention belongs to the field of natural medicine development, and relates to a method for obtaining a polysaccharide-protein complex from Pleurotus aureus fruiting body and its application in antagonizing and resisting muscle atrophy. Background technique [0002] Pleurotus citrinopileatus Singer, also known as elm yellow mushroom, golden top mushroom, jade emperor mushroom and yellow mushroom, is known as the crown of forest mushrooms and belongs to Basidiomycotina, Hymenomycetes ), Agaricales (Agaricales), Pleurotaceae (Pleurotaceae), Pleurotus (Agaricochaete), are relatively famous edible fungi in Northeast my country, with high nutritional value and medical care value. Studies have shown that it has the effects of nourishing and strengthening and stopping dysentery. Astragalus elm can also be used as medicine. [0003] At present, the development of medicinal value of Pleurotus aureus mainly focuses on immune regulation, anti-tumor and anti-o...

Claims

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Application Information

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IPC IPC(8): A61K36/07A61P21/00
Inventor 王琦宋则文刘洋李天舟胡会敏
Owner JILIN AGRICULTURAL UNIV
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