Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of rhodiola rosea in prevention and treatment of amyotrophy disease

A technique for muscle atrophy and Rhodiola rosea, which is used in muscular system diseases, neuromuscular system diseases, medical preparations containing active ingredients, etc.

Active Publication Date: 2012-10-17
SCI RES TRAINING CENT FOR CHINESE ASTRONAUTS
View PDF2 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there is no relevant report that Rhodiola rosea is used as the main active ingredient in the prevention and treatment of skeletal muscle atrophy

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of rhodiola rosea in prevention and treatment of amyotrophy disease
  • Application of rhodiola rosea in prevention and treatment of amyotrophy disease
  • Application of rhodiola rosea in prevention and treatment of amyotrophy disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0027] The sources of experimental animals and materials used in the following experiments are as follows:

[0028] Experimental animals: 30 macaques, aged 6-8 years, weighing 10-11 kg, body length 85-95 cm, male. Provided by Beijing Xierxin Biological Resources Research Institute, the production license number is: SCXK (Beijing) 2010-0007.

[0029] Test drug: Rhodiola rosea extract capsules. The test product Rhodiola rosea extract was purchased from Beijing Sihuan Pharmaceutical Co., Ltd. Its raw material is the dry root and rhizome of Rhodiola Kirilowii (Regel) Regel, a large plant of Crassulaceae. The main producing areas are Tibet, Sichuan, and Qinghai.

[0030] Additional material sources:

[0031] Tissue embedding agent was purchased from Thermo company;

[0032] Rabbit-derived laminin antibody was purchased from Abcam;

[0033] Goat anti-rabbit FITC fluorescently labeled secondary antibody was purchased from Invitrogen;

[0034] Trizol and reverse transcriptase we...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to application of rhodiola rosea in prevention and treatment of an amyotrophy disease. An experiment shows that the rhodiola rosea can inhibit the expression of amyotrophy specific factor Atrogin-1 in the amyotrophy generating process and the reduction of the cross sectional area of skeletal muscle fiber, and can regulate the content of protein related to the muscle fiber in amyotrophy so that slow-twitch fibers protein can be increased, and fast-twitch fibers protein can be reduced, as a result, the generation of amyotrophy is resisted. According to the application, the rhodiola rosea serving as the active ingredient can be used for preparing the medicament for preventing and controlling a skeletal muscle atrophy disease.

Description

Technical field: [0001] The invention relates to a new application of the plant drug Rhodiola rosea, in particular to the application of Rhodiola rosea or an extract of Rhodiola rosea in the prevention and treatment of muscular atrophy diseases. Background technique: [0002] Skeletal muscle can be divided into slow muscle and fast muscle according to its own metabolic characteristics, which are composed of slow muscle fiber protein and fast muscle fiber protein respectively. Under physiological conditions, the synthesis and degradation of skeletal muscle proteins and their fast and slow muscle fiber proteins are in a dynamic balance. However, clinical muscular dystrophy diseases (such as Duchenne muscular dystrophy, lateral sclerosis, etc.), disuse muscular atrophy (long-term bed rest, traumatic immobilization, weightlessness muscular atrophy during spaceflight, etc.), denervation / denervation Muscular atrophy, senile muscular atrophy, advanced muscular atrophy of malignant...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/41A61P21/00
Inventor 陈晓萍张鹏高月范明阚光捍刘红菊白延强
Owner SCI RES TRAINING CENT FOR CHINESE ASTRONAUTS
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com