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Application of rhodiola rosea in prevention and treatment of amyotrophy disease

A technique for muscle atrophy and Rhodiola rosea, which is applied in the fields of muscular system diseases, neuromuscular system diseases, medical preparations containing active ingredients, etc.

Active Publication Date: 2014-07-09
SCI RES TRAINING CENT FOR CHINESE ASTRONAUTS
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

But so far, there is no relevant report that Rhodiola rosea is used as the main active ingredient in the prevention and treatment of skeletal muscle atrophy

Method used

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  • Application of rhodiola rosea in prevention and treatment of amyotrophy disease
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  • Application of rhodiola rosea in prevention and treatment of amyotrophy disease

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Embodiment Construction

[0027] The sources of experimental animals and materials used in the following experiments are as follows:

[0028] Experimental animals: 30 macaques, aged 6-8 years, weighing 10-11 kg, body length 85-95 cm, male. Provided by Beijing Xierxin Biological Resources Research Institute, the production license number is: SCXK (Beijing) 2010-0007.

[0029] Test drug: Rhodiola rosea extract capsules. The test product Rhodiola rosea extract was purchased from Beijing Sihuan Pharmaceutical Co., Ltd. Its raw material is the dry root and rhizome of Rhodiola Kirilowii (Regel) Regel, a large plant of Crassulaceae. The main producing areas are Tibet, Sichuan, and Qinghai.

[0030] Additional material sources:

[0031] Tissue embedding agent was purchased from Thermo company;

[0032] Rabbit-derived laminin antibody was purchased from Abcam;

[0033] Goat anti-rabbit FITC fluorescently labeled secondary antibody was purchased from Invitrogen;

[0034] Trizol and reverse transcriptase we...

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Abstract

The invention relates to application of rhodiola rosea in prevention and treatment of an amyotrophy disease. An experiment shows that the rhodiola rosea can inhibit the expression of amyotrophy specific factor Atrogin-1 in the amyotrophy generating process and the reduction of the cross sectional area of skeletal muscle fiber, and can regulate the content of protein related to the muscle fiber in amyotrophy so that slow-twitch fibers protein can be increased, and fast-twitch fibers protein can be reduced, as a result, the generation of amyotrophy is resisted. According to the application, the rhodiola rosea serving as the active ingredient can be used for preparing the medicament for preventing and controlling a skeletal muscle atrophy disease.

Description

Technical field: [0001] The invention relates to a new application of the plant drug Rhodiola rosea, in particular to the application of Rhodiola rosea or an extract of Rhodiola rosea in the prevention and treatment of muscular atrophy diseases. Background technique: [0002] Skeletal muscle can be divided into slow muscle and fast muscle according to its own metabolic characteristics, which are composed of slow muscle fiber protein and fast muscle fiber protein respectively. Under physiological conditions, the synthesis and degradation of skeletal muscle proteins and their fast and slow muscle fiber proteins are in a dynamic balance. However, clinical muscular dystrophy diseases (such as Duchenne muscular dystrophy, lateral sclerosis, etc.), disuse muscular atrophy (long-term bed rest, traumatic immobilization, weightlessness muscular atrophy during spaceflight, etc.), denervation / denervation Muscular atrophy, senile muscular atrophy, advanced muscular atrophy of malignant...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/41A61P21/00
Inventor 陈晓萍张鹏高月范明阚光捍刘红菊白延强
Owner SCI RES TRAINING CENT FOR CHINESE ASTRONAUTS
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