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Antimicrobial coating compositions

An antimicrobial, antimicrobial peptide technology, used in coatings, biocides, drug delivery, etc.

Active Publication Date: 2015-09-16
BIOCANT CT DE INOVACAO EM BIOTECHA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Another disadvantage of these techniques is that after frequent use microorganisms may develop resistance against these coatings (Page, K; Wilson, M.; Parkin, I.P.J. Mater. Chem. 2009, 19, 3819)

Method used

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Embodiment Construction

[0043] The present invention relates to an antimicrobial coating composition for coating an article comprising an antimicrobial peptide; nanoparticles bound to said antimicrobial peptide; wherein said composition is suitable for binding to the surface of an article.

[0044]More preferably: the nanoparticles are suitable for binding to the surface of the article by heating, or the composition further comprises a binder for binding the composition to the surface of the article.

[0045] In the subject of the present invention, antimicrobial peptides (eg: cecropin melittin) and buffers (eg: HEPES-(4-(2-hydroxyethyl)-1- Effect of piperazineethanesulfonic acid) concentration, buffer pH and peptide chain on the formation process of gold nanoparticles. Cecropin melittin (CM) peptides with and without cysteine ​​at the C-terminus were used for the synthesis of gold nanoparticles. The sulfhydryl group of cysteine ​​residues was found to play a key role in controlling the size and mor...

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Abstract

The invention relates to an antimicrobial coating composition for coating articles comprising: an antimicrobial peptide and a nanoparticle bound to said antimicrobial peptide, wherein the composition is suitable to be bonded to the surface of the article. The composition can comprise a coating composition of medical devices and laboratory surfaces.

Description

technical field [0001] The subject matter of the present disclosure relates to an antimicrobial coating composition for coating an article, comprising: an antimicrobial peptide; nanoparticles bound to said antimicrobial peptide, wherein the composition is suitable for binding to the surface of the article . The compositions can be used as coating compositions for medical devices and laboratory surfaces. Background technique [0002] Due to their unique surface plasmon resonance (SPR) properties, stability, biocompatibility, ease of synthesis, and surface functionalization, metal nanoparticles have been used in biosensors, drug delivery, antimicrobial materials, and other biological Extensively researched for medical applications 1 . Several reports are available in the literature on the preparation of antimicrobial metal nanoparticles with broad antimicrobial spectrum 2,3 . These methods include multiple steps involving the synthesis of nanoparticles, surface functional...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N37/46A61L27/00A61K38/10A61L29/08A61L31/08
CPCA01N37/46A61L2420/02A61L2300/102A61K38/1703A61K47/48884A01N55/02A61L2300/25A61K38/10A61L2300/404A61L27/54A01N25/22A61L2400/12A61L27/34A61K47/6929Y10T428/2982A01N25/10A01N25/34A01N59/16A01N2300/00
Inventor 利诺·达 西尔瓦 费雷拉阿希莱什·雷
Owner BIOCANT CT DE INOVACAO EM BIOTECHA
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