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Traditional Chinese medicine eye-drop for treating xeroma and preparation method thereof

A technology for eye drops and dry eye syndrome, applied in the field of traditional Chinese medicine, can solve the problems of limited research and inability to treat local dry eye syndrome, and achieve the effects of promoting ocular surface healing, improving subjective symptoms, and increasing tear secretion

Active Publication Date: 2015-08-26
HUNAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The most critical factor in the pathogenesis of dry eye is inflammation. The current conventional treatment is tear replacement, which can only relieve symptoms and cannot provide a fundamental treatment for the cause. Chinese medicine has a long history, and Chinese medicine has its own advantages in the treatment of dry eye, which can improve Ocular surface symptoms, improve the body's immunity, and have a certain regulatory effect on the patient's whole body. Traditional Chinese medicine is rich in sources, low in price, and has few side effects. However, research on local treatment of dry eye is relatively limited

Method used

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  • Traditional Chinese medicine eye-drop for treating xeroma and preparation method thereof
  • Traditional Chinese medicine eye-drop for treating xeroma and preparation method thereof
  • Traditional Chinese medicine eye-drop for treating xeroma and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0019] (1) Polygonatum 10g was soaked in water for 1 hour, refluxed and extracted twice, the first time was 10 times the amount of water extraction for 2.5 hours, the second time was 8 times the amount of water extraction for 2 hours, filtered, the two filtrates were combined, and concentrated under reduced pressure at 80°C To a relative density of about 1.08 ~ 1.10 (60 ℃ thermal measurement). Put the concentrated solution at room temperature, add ethanol under stirring to make the alcohol content reach 80%, let it stand for more than 24 hours, filter, take the precipitate, heat to dissolve, add an appropriate amount of distilled water (up to 100ml), add 0.2% (g / ml) a Activated carbon for grade needles (activated carbon should be dried in an oven at 150°C for 4 hours before use), boiled for 30 minutes, let cool, and refrigerated at 4°C for 24 hours;

[0020] (2) Add 10 times the amount of water to Houttuynia cordata 100g, distill and extract, collect 6 times the amount of arom...

Embodiment 2

[0024] (1) 20g of Rhizoma Polygonatum was soaked in water for 1 hour, refluxed for 2 times, the first time was extracted with 10 times of water for 2.5 hours, the second time was extracted with 8 times of water for 2 hours, filtered, the two filtrates were combined, concentrated under reduced pressure at 80°C To a relative density of about 1.08 ~ 1.10 (60 ℃ thermal measurement). Put the concentrated solution at room temperature, add ethanol under stirring to make the alcohol content reach 80%, let it stand for more than 24 hours, filter, take the precipitate, heat to dissolve, add an appropriate amount of distilled water (up to 200ml), add 0.2% (g / ml) a Activated carbon for grade needles (activated carbon should be dried in an oven at 150°C for 4 hours before use), boiled for 30 minutes, let cool, and refrigerated at 4°C for 24 hours;

[0025] (2) Add 10 times the amount of water to Houttuynia cordata 150g, distill and extract, collect 6 times the amount of aromatic water, and...

Embodiment 3

[0029] (1) 50g of Rhizoma Polygonatum is soaked in water for 1 hour, reflux extraction twice, the first extraction with 10 times the amount of water for 2.5 hours, the second extraction with 8 times the amount of water for 2 hours, filtering, combining the two filtrates, and concentrating under reduced pressure at 80°C To a relative density of about 1.08 ~ 1.10 (60 ℃ thermal measurement). Put the concentrated solution at room temperature, add ethanol under stirring to make the alcohol content reach 80%, let it stand for more than 24 hours, filter, take the precipitate, heat to dissolve, add an appropriate amount of distilled water (to 400ml), add 0.2% (g / ml) a Activated carbon for grade needles (activated carbon should be dried in an oven at 150°C for 4 hours before use), boiled for 30 minutes, let cool, and refrigerated at 4°C for 24 hours;

[0030] (2) Add 10 times the amount of water to 200g Houttuynia cordata, extract by distillation, collect 6 times the amount of aromatic...

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Abstract

The invention discloses a traditional Chinese medicine eye-drop for treating xeroma. The eye-drops is prepared from the following components by weight: 10-50 parts of solomon's seal and 100-200 parts of Houttuynia. The method is as below: first conducting heat reflux extraction, concentration under reduced pressure, alcohol precipitation, bleaching and filtration to obtain a solomon's seal solution; distilling Houttuynia to obtain a Houttuynia aqua aromatica; then mixing the solomon's seal solution and aqua aromatica; adjusting the pH value and osmotic pressure to obtain a light yellow transparent liquid; and then disinfecting and bottling. The solomon's seal and Houttuynia in the traditional Chinese medicine eye-drop have anti-viral and anti-inflammatory effects; the solomon's seal polysaccharide contained in solomon's seal increases tear secretion and promotes healing of the ocular surface; the two components have good effects in improving patient subjective symptoms and increasing tear secretion; the preparation method is simple and low in cost; and the eye-drop is easy to use and can be easily accepted by the patients.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine eye drop for treating dry eye and a preparation method thereof. Background technique [0002] Dry eye syndrome, also known as keratoconjunctival dryness or tear insufficiency syndrome, refers to the tear film stability decrease caused by abnormal tear quality and quantity or abnormal dynamics, accompanied by eye discomfort, leading to ocular surface tissue lesions. It is a general term for diseases and is one of the most common ophthalmic diseases at present. The disease is more common in middle-aged and elderly people, and seriously affects the quality of life of patients. With the acceleration of the pace of human life, problems such as dry climate, air pollution, and aging population are becoming more and more serious, the popularity of high-tech products and the wide application of contact lenses, the incidence of dry eye s...

Claims

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Application Information

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IPC IPC(8): A61K36/8969A61P27/02
Inventor 李点
Owner HUNAN UNIV OF CHINESE MEDICINE
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