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Traditional Chinese medicine compound composition with anti-breast cancer activity and its preparation method and application

An anti-breast cancer and composition technology, which is applied in the direction of drug combinations, medical preparations containing active ingredients, anti-tumor drugs, etc., can solve the problems of large dosage, many impurities, and ineffective curative effect, and achieve less dosage , scientific and reasonable ratio, exact and reliable curative effect

Active Publication Date: 2018-03-02
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology

However, the reported anti-breast cancer traditional Chinese medicine compound dosage is relatively large, there are many impurities, and the curative effect is not obvious.

Method used

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  • Traditional Chinese medicine compound composition with anti-breast cancer activity and its preparation method and application
  • Traditional Chinese medicine compound composition with anti-breast cancer activity and its preparation method and application
  • Traditional Chinese medicine compound composition with anti-breast cancer activity and its preparation method and application

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preparation example Construction

[0036] 2. the preparation method of the Chinese medicine compound composition with anti-breast cancer activity of the present invention, it may further comprise the steps:

[0037] (1) Take 15 grams of Leulu, 15 grams of Tiankuizi, 6 grams of Vinegar Bupleurum, 10 grams of Asparagus, 15 grams of Prunella vulgaris, 10 grams of August Zha, and add 12 times the volume of the total medicinal materials A large amount of ethanol was ultrasonically extracted 3 times for 2 hours each time, the extracts were combined and concentrated under reduced pressure to obtain a macroporous adsorption resin column on the concentrate, which was first eluted with water, and then washed successively with ethanol with a volume concentration of 20% to 60%. stripping; collecting ethanol eluent with a combined volume concentration of 40-60%, and concentrating to obtain the extract;

[0038] (2) Take the extract obtained in step (1), add lactose and cornstarch, mix evenly, add lubricant magnesium stearat...

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Abstract

The invention discloses a Chinese medicine compound composition with anti-breast cancer activity, its preparation method and its application. The Chinese medicine compound composition consists of 15-45 parts of Leulu, 15-45 parts of Tiankuizi, 6-6 parts of Bupleurum bupleuri. 18 parts, 10 to 30 parts of Asparagus, 15 to 45 parts of Prunella vulgaris, and 10 to 30 parts of August Zha. Experimental results show that the traditional Chinese medicine compound composition with anti-breast cancer activity provided by the present invention has rigorous medication, scientific and reasonable proportioning, has anti-cancer and detoxification effects, reduces phlegm and blood stasis, and nourishes qi and nourishes yin. It has a strong killing effect; it can also improve the immunity of tumor patients, improve the quality of life, and has high safety and low toxic and side effects. At the same time, the preparation method provided by the invention has stable quality, high content of extracted active ingredients, strong operability, and is suitable for large-scale industrial production.

Description

technical field [0001] The invention relates to a traditional Chinese medicine, in particular to a compound traditional Chinese medicine composition with anti-breast cancer activity and its preparation method and application. Background technique [0002] Breast cancer is one of the most common malignant tumors in women. According to statistics, the incidence rate accounts for 7-10% of all kinds of malignant tumors in the whole body. It is second only to uterine cancer in women. Its incidence is often related to genetics, and 40-60 Between the ages, women before and after menopause have a higher incidence. Malignant tumors usually occurring in the glandular epithelium of the breast. It is one of the most common malignant tumors that seriously affects women's physical and mental health and even threatens their lives. Clinically, the current drugs for the treatment of breast cancer mainly include chemical drugs. However, due to the high toxicity of chemotherapy drugs, they c...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8965A61P35/00
Inventor 程海波周仲瑛沈卫星李柳孙东东徐长亮谭佳妮沈政洁吴东东
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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