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A composition for inhibiting Helicobacter pylori and its application

A Helicobacter pylori and composition technology, which is applied in the field of pharmaceutical compositions for inhibiting Helicobacter pylori, can solve the problems of unsatisfactory use effect and single medicinal ingredient, and achieve the effects of reducing indigestion, good drug efficacy, and improving activity

Active Publication Date: 2019-07-05
梅州市和谐生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the relevant Chinese patent medicine preparations on the market today have a single active ingredient, and are rarely compounded with other medicinal ingredients, and the actual use effect is still not ideal.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: the preparation of Hericium erinaceus

[0024] Take Hericium erinaceus, wash, dry in the dark, pulverize, mix, pass through a 20-200 mesh sieve to obtain Hericium erinaceus powder. Under an inert gas atmosphere, according to the mass volume ratio of Hericium erinaceus and 95% ethanol solution of 1:10 Kg / L, prepare an alcohol extraction solution, ultrasonic extraction at 300W for 24 hours, and repeat twice under this condition. Combine the obtained alcohol solutions, let stand, filter to remove insoluble matter, remove the solvent by rotary evaporation, and recrystallize from chloroform to obtain Hericium erinaceus extract.

Embodiment 2-3

[0025] Example 2-3: Preparation of Sophora Sophorae and Coptidis Rhizoma Extract

[0026] With reference to the method of Example 1, the extracts of Sophora Sophora and Coptis Rhizoma were prepared respectively.

Embodiment 4

[0027] Embodiment 4: the preparation of composition of the present invention

[0028] The extracts of Hericium erinaceus, Sophora Sophora and Coptidis Rhizoma obtained in Example 1-3 are stirred evenly according to the mass ratio of 15:15:6, 18:12:8, 20:10:10, ground and pulverized, Get the finished product.

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PUM

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Abstract

The application relates to the field of biotechnologies, and particularly relates to a composition, an application and a preparation method. The composition contains hericium erinaceus, sophora alopecuroide and a coptis chinensis extract, and can be used for treating or preventing the various diseases caused by helicobacter pylori, wherein the diseases comprise various digestive system diseases, in particular, gastritis (for example, chronic active gastritis and chronic atrophic gastritis), peptic ulcers (for example, gastric ulcer and duodenal ulcer), ulcerative colitis or digestive tract malignancies (for example, gastric cancer) and the like. The raw materials of the composition disclosed by the invention are easily available, the preparation process is simple, the obtained quality is high in quality, the composite cost is controllable, and the composition is suitable for industrialized production.

Description

technical field [0001] The invention relates to a pharmaceutical composition for inhibiting Helicobacter pylori, belonging to the technical field of biomedicine. Background technique [0002] It has been confirmed that Helicobacter pylori (Hp) is the pathogenic bacterium of chronic active gastritis and an important pathogenic factor of peptic ulcer. The persistent infection of Helicobacter pylori can lead to the occurrence of chronic atrophic gastritis. disease are closely related. Studies have shown that compared with uninfected people, the risk of gastric cancer in people infected with Helicobacter pylori is 2-6 times higher, and the eradication of Helicobacter pylori can significantly reduce the incidence of gastric cancer. The World Health Organization has listed Helicobacter pylori as a first-class carcinogen. Clinically, it is difficult to eradicate Hp infection with a single antibiotic, so a combination of different drugs is often used. Although this combination th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/718A61P31/04A61P1/04A61P35/00
Inventor 杨克西王炜颜丙春王芬
Owner 梅州市和谐生物科技有限公司
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