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Beta-cyclodextrin/polyethylene imine/graphene oxide composite material, preparation method thereof, composition and detection method

A technology of polyethyleneimine and composite materials, which is applied in the direction of material excitation analysis, fluorescence/phosphorescence, etc., can solve the problems of using toxic reagents, complicated operation, and time-consuming, etc., and achieve the effect of low detection limit and simple operation

Inactive Publication Date: 2015-07-08
ANHUI NORMAL UNIV
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Problems solved by technology

[0005] In view of the above-mentioned prior art, the purpose of the present invention is to overcome the problems that most of the detection methods for β-carotene in the prior art require the use of a large amount of toxic reagents, complex operations and time-consuming problems, thereby providing a β-cyclodextrin / Polyethyleneimine / graphene oxide composite material and preparation method, composition and detection method

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  • Beta-cyclodextrin/polyethylene imine/graphene oxide composite material, preparation method thereof, composition and detection method
  • Beta-cyclodextrin/polyethylene imine/graphene oxide composite material, preparation method thereof, composition and detection method
  • Beta-cyclodextrin/polyethylene imine/graphene oxide composite material, preparation method thereof, composition and detection method

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preparation example Construction

[0031] The present invention also provides a preparation method according to the above-mentioned β-cyclodextrin / polyethyleneimine / graphene oxide composite material, the reaction mechanism diagram is as follows figure 1 Shown, wherein, described preparation method comprises:

[0032] (1) In the presence of the first organic solvent, carry out the first contact reaction of β-cyclodextrin and N,N'-carbonyldiimidazole to prepare N,N'-carbonyldiimidazole-β-cyclodextrin;

[0033] (2) In the presence of a second organic solvent and an organic base, the N,N'-carbonyldiimidazole-β-cyclodextrin is grafted with polyethyleneimine to obtain a β-cyclodextrin-polyethyleneimine Ethylene imine;

[0034] (3) In the presence of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide, the β-cyclodextrin-polyethylene The imine and graphene oxide are subjected to a second contact reaction in a phosphate buffer solution to prepare a β-cyclodextrin / polyethyleneimine / gra...

Embodiment

[0063] Dissolve 2.1g of β-cyclodextrin and 4.0g of N,N'-carbonyldiimidazole in 25mL of N,N'-dimethylformamide and mix at 25°C for 1h under nitrogen protection to obtain mixture M1; Mixture M1 was placed in diethyl ether at -2°C for 1 hour, and N,N'-carbonyldiimidazole-β-cyclodextrin was obtained after filtration; N,N'-carbonyldiimidazole-β-cyclodextrin was dried and dissolved in 25mL dimethyl sulfoxide to obtain a mixture M3; 7.5g polyethyleneimine was dissolved in 15mL dimethyl sulfoxide to obtain a mixture M4; the mixture M3 and 1.5mL triethylamine were mixed at 40 drops / min The rate was added dropwise into the mixture M4, and left for 5 hours to obtain the mixture M5; the mixture M5 was dialyzed with deionized water for 3 days, and β-cyclodextrin-polyethyleneimine was obtained after freeze-drying.

[0064] Disperse 0.5g of graphene oxide in 25mL of phosphate buffer solution, sonicate for 30min under magnetic stirring, and dissolve 1-(3-dimethylaminopropyl)-3-ethylcarbodiimi...

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Abstract

The invention discloses a beta-cyclodextrin / polyethylene imine / graphene oxide composite material, a preparation method thereof, a composition and a detection method. The structure of the beta-cyclodextrin / polyethylene imine / graphene oxide composite material is represented by formula (I) shown in the specification, and n in the formula is a positive integer. The beta-cyclodextrin / polyethylene imine / graphene oxide composite material is synthesized through synthesizing beta-cyclodextrin-polyethylene imine by grafting beta-cyclodextrin to polyethylene imine and through modifying the surface of graphene oxide with beta-cyclodextrin-polyethylene imine. A host-guest competitive inclusion fluorescence recovery process between beta-carotene in the beta-cyclodextrin / polyethylene imine / graphene oxide composite material and a guest molecule rhodamine 6G and beta-carotene carotene is used to detect beta-carotene, so fluorescence process detection of beta-carotene is realized in order to realize simple operation, low detection limit, rapidness and effectiveness.

Description

technical field [0001] The invention relates to the field of materials for component analysis, in particular to a β-cyclodextrin / polyethyleneimine / graphene oxide composite material, a preparation method, a composition and a detection method. Background technique [0002] With the rapid development of economy and society, the morbidity and mortality of cancer are on the rise, so the prevention, control and treatment of cancer has become the focus of the world's most attention. β-carotene is a typical representative of carotenoids. It is a natural pigment with important physiological functions widely present in carrots, yellow pumpkins, dark green leafy vegetables, mangoes, corns, tomatoes, citrus and other fruits and vegetables. An essential class of β-cyclodextrin / polyethyleneimine / graphene oxide composites is not only an important source of vitamin A in the body, but also one of the important dietary components, and it can also prevent, delay and treat certain diseases, Es...

Claims

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Application Information

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IPC IPC(8): C08G83/00G01N21/64
Inventor 台德艳刘国宁刘金水
Owner ANHUI NORMAL UNIV
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