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Method for treating lung cancer by improving autogenous DC-CIK immunocytes

A DC-CIK, immune cell therapy technology, applied in the direction of mammalian medical raw materials, drug combinations, anti-tumor drugs, etc., can solve problems such as high cost and poor effect, achieve broad market prospects, and improve the effect of recovery probability.

Inactive Publication Date: 2015-06-24
ZHOUSHAN HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] The problem to be solved by the present invention is that the existing chemotherapy for lung cancer has the disadvantage of high cost and poor effect.

Method used

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Embodiment Construction

[0042] The present invention will be further described below in conjunction with embodiment.

[0043] A method for improving autologous DC-CIK immune cells to treat lung cancer, comprising the following steps:

[0044] A. Patient selection, inclusion criteria for lung cancer patients: age ≤ 75 years old; Karnofsky score > 60; expected survival > 6 months, exclusion criteria: 1. Pregnant or lactating women 2. Organ failure; 3. Organs Transplant recipients; 4. Patients with severe autoimmune diseases; 5. Uncontrollable infectious diseases; 6. Those who are allergic to biological agents used in treatment; 7. T-cell lymphoma; 8. Those who hinder the signing and understanding of informed consent;

[0045] B. Examination and evaluation before treatment, enhanced chest CT; routine blood test (WBC>3.0×10*9 / L, LC>15%; Hb>80g / L; PLT>60×10*9 / L), liver and kidney Function, PT (prolongation <50%), T lymphocyte subsets, tumor markers, detection of SCC (squamous cell carcinoma); hepatitis B...

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PUM

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Abstract

The invention provides a method for treating lung cancer by improving autogenous DC-CIK immunocytes. The method comprises the following steps: selecting patients according to a lung cancer patient inclusion criteria that the age is less than or equal to 75 years, the Karnofsky score is more than 60 and the estimated lifetime is more than 6 months; performing inspection and evaluation before treatment, namely performing chest CT (computed tomography) enhancement, performing blood routine examination, detecting liver and kidney functions, detecting the PT (prothrombin time) (prolonging for less than 50%), detecting T lymphocyte subsets and tumor markers, detecting SCC (squamous cell carcinoma), and detecting three systems of hepatitis B (negative surface antigen), negative hepatitis C antibody, negative HIV antibody and negative syphilis antibody; after determination, sending an application form to a biological treatment center; performing pure autogenous immunocyte treatment, sampling 75ml of blood, performing cell culture for 11 days or sampling 75ml of blood on the day before GP chemotherapy / radiotherapy and autogenous immunocyte treatment chemotherapy, and performing cell culture for 11 days; and performing quality detection on the cultured cells on the eleventh day and the thirteenth day.

Description

technical field [0001] The invention relates to a method for improving autologous DC-CIK immune cells to treat lung cancer, belonging to the field of lung cancer treatment. Background technique [0002] Lung cancer does not have any special symptoms in the early stage, only common symptoms of general respiratory diseases, such as cough, bloody sputum, low-grade fever, chest pain, shortness of breath, etc., which are easy to ignore. [0003] Specific manifestations of common early symptoms of lung cancer: [0004] 1. Cough Lung cancer usually produces respiratory tract irritation symptoms and irritating cough because it grows on the bronchopulmonary tissue; [0005] 2. Low-grade fever. After the tumor blocks the bronchi, obstructive lung lobes often exist, with varying degrees. Mild cases only have low-grade fever, while severe cases have high fever. After taking medicine, it can temporarily improve, but it will relapse soon; [0006] 3. Chest pain In the early stage of lun...

Claims

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Application Information

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IPC IPC(8): A61K35/14A61K35/15A61P35/00
Inventor 张永奎乐涵波续力云陈志军刘晓光
Owner ZHOUSHAN HOSPITAL
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