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Semi-automatic quantification method based on development specificity extraction ratio of dopamine transporter

A quantitative method and specific technology, applied in computerized tomography scanners, echo tomography, etc., can solve problems such as lack of repeatability, poor robustness, and long time consumption, so as to reduce differences, improve accuracy and Robustness, the effect of improving processing efficiency

Inactive Publication Date: 2015-06-24
SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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  • Application Information

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Problems solved by technology

This processing method takes a long time and is inefficient. There are subjective differences between different operators, and the calculation results are different. Even if the same operator performs multiple processing, there are errors, so the robustness is poor and it does not have repeatability.

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  • Semi-automatic quantification method based on development specificity extraction ratio of dopamine transporter
  • Semi-automatic quantification method based on development specificity extraction ratio of dopamine transporter
  • Semi-automatic quantification method based on development specificity extraction ratio of dopamine transporter

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Embodiment Construction

[0026] Embodiments of the present invention will be described below in conjunction with exemplary embodiments. It should be understood that in the development of any such practical implementation, many specific implementations must be adopted to achieve the specific goals of the developer, for example, identification and segmentation of striatal boundaries can be achieved by multiple methods; setting Different physiological mathematical models can complete the quantitative calculation of dopamine transporters. While the invention is susceptible to various modifications and alternative forms, specific embodiments of the invention have been shown by way of example in the drawings and described in detail herein. It should be noted that the present invention is not limited to the specific forms disclosed, and that the description of specific embodiments is for a more complete and thorough understanding of the invention.

[0027] Please refer to figure 1 , this semi-automatic qua...

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Abstract

A semi-automatic quantification method based on a development specificity extraction ratio of a dopamine transporter includes the following steps of collecting faulted image data of the dopamine transporter; calibrating a faulted image range where a corpus striatum is located in the collected faulted image data; automatically dividing a corpus striatum area and a reference area in each calibrated faulted image; extracting the grey values of all pixels in the corpus striatum areas to serve as corpus striatum area specificity extraction count values; extracting the grey values of all pixels in the reference areas to serve as reference area specificity extraction count values; summarizing the corpus striatum area specificity extraction count values and the reference area specificity extraction count values in all the calibrated faulted images, and working out the ratio to serve as the development specificity extraction ratio. The semi-automatic quantification method can improve the efficiency, accuracy and robustness of development analysis of the dopamine transporter.

Description

technical field [0001] The invention relates to a semi-automatic quantification method based on the specific uptake ratio of dopamine transporter imaging, and relates to the technical fields of image processing, computer vision and nuclear medicine. Background technique [0002] Dopamine transporter (dopamine transporter, DAT) is located in the presynaptic membrane of dopaminergic neurons in the central brain. Target of many neurotransmitters. The functional imaging of dopamine transporter (DAT) in nuclear medicine is through intravenous injection of radioactive molecular probes, using the physiological principle of specific binding of dopaminergic neurons to DAT, in vitro using Single-Photon Emission Computed Tomography (Single-Photon Emission Computed Tomography, SPECT) equipment to observe the functional state of the brain. The dopamine transporter is mainly concentrated in the striatum region of the brain, so the quantitative analysis of the spatial distribution, locat...

Claims

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Application Information

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IPC IPC(8): A61B6/03
Inventor 袁克虹王彤李怡雪
Owner SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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