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Peritoneal dialysis solution composition containing multiple alpha-ketone acid calcium

A technology of peritoneal dialysate and calcium ketoacid, applied in the field of peritoneal dialysate composition, can solve the problems such as the exact mechanism is not completely clear

Inactive Publication Date: 2015-06-10
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its characteristic is that the levels of most essential amino acids and total essential amino acids in plasma are reduced, while the levels of some non-essential amino acids are relatively high, especially after protein loading. The exact mechanism is not yet fully understood.

Method used

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  • Peritoneal dialysis solution composition containing multiple alpha-ketone acid calcium
  • Peritoneal dialysis solution composition containing multiple alpha-ketone acid calcium
  • Peritoneal dialysis solution composition containing multiple alpha-ketone acid calcium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The formula is as follows, the packaging specification is 1000ml / bag, and the data in the table is the formula equivalent to each bag of dialysate

[0022]

[0023]

[0024] 1. Take 20% water for injection, put in the weighed glucose, racemic ketoisoleucine calcium, ketoleucine calcium, ketophenylalanine calcium, ketovaline calcium and stir to dissolve. After all dissolve, Use sodium chloride, 5% HCl aqueous solution or 5% NaOH aqueous solution, and water for injection to adjust the pH value as shown in the above table, isotonic and dilute to full volume. Then add medicinal charcoal 0.1 ~ 1% (g / ml) and stir evenly, the liquid medicine is filtered through a 0.22μm terminal filter until the visible foreign matter is qualified and then potted (1000ml or 2000ml per bag)

[0025] 2. Sterilization: 115°C constant temperature for 20 minutes

[0026] Use nitrogen protection during preparation and potting.

Embodiment 2

[0028] The formula is as follows, the packaging specification is 1000ml / bag, and the data in the table is the formula equivalent to each bag of dialysate

[0029]

[0030] The preparation method is the same as in Example 1.

Embodiment 3

[0032] The formula is as follows, the packaging specification is 1000ml / bag, and the data in the table is the formula equivalent to each bag of dialysate

[0033]

[0034]

[0035] The preparation method is the same as in Example 1.

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Abstract

The invention discloses a peritoneal dialysis solution composition, which contains 1.5%-4.25% of glucose, sodium chloride, multiple alpha-ketone acid calcium and water, wherein the multiple alpha-ketone acid calcium are calcium 3-methyl-2-oxovalerate, ketoleucine calcium, ketophenylalanine calcium and ketovaline calcium.

Description

technical field [0001] The invention relates to a peritoneal dialysis fluid composition of various α-ketoacid calcium. Background technique [0002] Chronic renal insufficiency (CRF) refers to chronic progressive renal parenchymal damage caused by various reasons, resulting in obvious atrophy of the kidneys, unable to maintain basic functions. The main clinical syndrome. The accumulation of toxins produced by protein metabolism in the body is one of the important pathogenesis of chronic renal insufficiency. The degree of uremic symptoms is directly related to the accumulation of protein metabolites. A low-protein diet can reduce the symptoms of uremia and slow down the further deterioration of chronic renal insufficiency. However, restricting protein can lead to a lack of essential amino acids in the body. In the past ten years, with the increasing clinical application of peritoneal dialysis technology, the survival period of uremia patients has been prolonged correspond...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61P7/08A61P13/12A61P3/12A61P3/00A61K31/19A61K31/192A61K31/7004
Inventor 孙亮
Owner TIANJIN JINYAO GRP
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