Method for recycling DCPC (deacetyl cephalosporin C) from cephalosporin C resin adsorption waste liquor

Abstract

The invention provides a method for recycling DCPC from cephalosporin C resin adsorption waste liquor. According to the method, an anion exchange resin 1 is firstly used for removing residual inorganic anions, particularly sulfate ions, in the adsorption raffinate; and the remaining feed liquid is adsorbed by a macroporous adsorption resin, a salt solution is used as desorption agent, the elutriant is directly concentrated by nanofiltration after being decolored through an anion exchange resin 2, further, after the processes of splitting decomposition, crystallization, drying, and so on, a D-7ACA qualified product with purity of not less than 98% and color grade of more than 4 is obtained. Resin extraction yield is not less than 85%, and total yield of the process is not less than 45%.

Description

Technical field: [0001] The invention belongs to the field of chemical pharmacy, and in particular relates to a method for recovering DCPC from cephalosporin C resin adsorption waste liquid by adopting resin. Background technique: [0002] Cephalosporin C is the raw material for the semi-synthesis of cephalosporin antibiotic intermediate 7-aminocephalosporanic acid (abbreviated 7-ACA). At present, the production of cephalosporin C is generally carried out by solid-liquid separation after three-stage or four-stage fermentation of Cephalosporin acremonium to obtain a clarified supernatant, and then undergo two to three-step resin treatment to remove cephalosporin C analogues and pigments and other impurities, the resulting solution is directly subjected to enzymatic cleavage to produce 7-ACA. [0003] After the cephalosporin C fermentation liquid is obtained through solid-liquid separation to clarify the supernatant, the cephalosporin C (hereinafter referred to as CPC) in the...

AI Technical Summary

Problems solved by technology

At present, the adsorption raffinate of various manufacturers does not recycle the DCPC in it, and directly discharges it into the wastewater system, which not only pollutes the environment, but also causes a great waste of resources.

[0004] The disclosed method of USP3926729 is to use macroporous strong base anion exchange resin etc. to adsorb DCPC. The decolorization effect of pigment impurities is relatively poor

Yu Haijun (the separation and purification of deacetylcephalosporin C, "Journal of Chemical Industry", 2010, 61) mentioned that the coal-based granular activated carbon with a particle size distribution of 0.27-1.70mm is used as an adsorbent to carry out the adsorption separation of DCPC. This method has the following defects : (1) The use of granular activated carbon has a low adsorption capacity (only 11g / L), and organic solvents are required for desorption and regeneration, causing secondary pollution to the environment and high extraction costs; (2) Using anion exchange resin to directly adsorb DC Then desorb on the resin, which increases the cost of operation and the pigment will also enter the subsequent process with DC during the desorption process, resulting in unqualified product color grade and purity

Patent 200910050248 uses macroporous styrene-type non-polar adsorption resin to adsorb CPC, and then purifies DCPC through gel-type strong base type II anion exchange resin. There are defects in this method: (1) the exchange capacity of strong base type II resin is small and The decolorization effect is poor, which will lead to the decline of the quality of the main product CPC; (2) the chloride ions produced during the resin transformation process will interfere with the cleavage of the enzyme, resulting in a decrease in enzyme activity and a decrease in life; (3) for strong alkali type II When the resin is desorbed to obtain DC products, pigment impurities and CPC adsorbed by the resin will also enter the product at the same time, resulting in poor product quality

Therefore, the methods for recovering DCPC in the prior art are not conducive to the promotion and application in industrial production.

Images