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A traditional Chinese medicine composition for nourishing blood and calming the nerves and its preparation method

A technology for nourishing blood and calming the nerves and a composition is applied in the directions of drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc. Problems such as over-the-counter medicines to prolong sleep time and induce sleep

Active Publication Date: 2018-05-29
吉林修正药业新药开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The active ingredients cannot be fully extracted; the authorized patent with the patent number CN102133320 discloses a traditional Chinese medicine preparation for the treatment of generalized anxiety disorder and its preparation method.
At present, there are many Chinese patent medicines for treating insomnia on the market, but there is no Chinese patent medicine for treating insomnia with blood deficiency and yang floating syndrome

Method used

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  • A traditional Chinese medicine composition for nourishing blood and calming the nerves and its preparation method
  • A traditional Chinese medicine composition for nourishing blood and calming the nerves and its preparation method
  • A traditional Chinese medicine composition for nourishing blood and calming the nerves and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Take 140g of schisandra and extract with 5 times the amount of 80% ethanol at reflux for three times for 2 hours each time. Combine the extracts and recover the ethanol until there is no alcohol smell for use;

[0056] Take 140g of Ligusticum chuanxiong and add 6 times the amount of water, extract the volatile oil by steam distillation (12 hours), and collect the dregs and liquid separately; the volatile oil is dissolved in an equal volume of absolute ethanol and added dropwise to the β-cyclodextrin solution , The volume of β-cyclodextrin solution water ml: β-cyclodextrin weight g is 8:1, the volume of volatile oil ml: β-cyclodextrin weight g is 1:4, dissolve by heating, keep warm at 60℃, and stir At a speed of 150 revolutions / min, add volatile oil dropwise, stir for 1.5 hours, place it in a refrigerator at 0-4°C for 24 hours, filter with suction, dry the filter residue at 40°C, crush, and pass through a 100-mesh sieve to obtain the volatile oil inclusion compound. spare; ...

Embodiment 2

[0060] Take 100g of schisandra and extract with 8 times the amount of 50% ethanol at reflux for three times, 1 hour each time, combine the extracts, and recover the ethanol until there is no alcohol smell for use;

[0061] Take 200g of Ligusticum chuanxiong and add 8 times the amount of water, extract the volatile oil by steam distillation (10 hours), and collect the medicine residue and liquid separately; the volatile oil is dissolved with an equal volume of absolute ethanol and added dropwise to the β-cyclodextrin solution , The volume of β-cyclodextrin solution water ml: β-cyclodextrin weight g is 10:1, the volume of volatile oil ml: β-cyclodextrin weight g is 1:4, dissolve by heating, keep warm at 50℃, and stir Under the condition of 150 revolutions per minute, volatile oil was added dropwise, stirred for 1 hour, placed in a refrigerator at 0-4°C for 24 hours, filtered with suction, dried at 40°C, crushed, and passed through a 100 mesh sieve to obtain the volatile oil inclusio...

Embodiment 3

[0065] Take 200 g of schisandra and extract with 10 times the amount of 90% ethanol at reflux for three times for 2 hours each time. Combine the extracts and recover the ethanol until there is no alcohol smell for use;

[0066] Take 100g of Ligusticum chuanxiong and add 10 times the amount of water, extract the volatile oil by steam distillation (8 hours), and collect the dregs and liquid separately; the volatile oil is dissolved with an equal volume of absolute ethanol and added dropwise to the β-cyclodextrin solution , The volume of β-cyclodextrin solution water ml: β-cyclodextrin weight g is 9:1, the volume of volatile oil ml: β-cyclodextrin weight g is 1:6, dissolve by heating, keep warm at 60℃, and stir At a speed of 150 revolutions / min, add volatile oil dropwise, stir for 2 hours, put it in a refrigerator at 0-4°C for 24 hours, filter with suction, dry the filter residue at 40°C, crush, and pass through a 100-mesh sieve to obtain the volatile oil inclusion compound. spare; ...

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Abstract

A traditional Chinese medicine composition for nourishing blood and soothing the nerves and its preparation method. The traditional Chinese medicine composition is composed of ethanol reflux extract of Schisandra chinensis obtained from jujube seed, cypress kernel, Schisandra chinensis, keel, oyster, mother of pearl, Zhimu, Chuanxiong, Poria cocos and licorice, and the rest A mixture of raw water extracts. The preparation method comprises: reflux extracting the schisandra ethanol aqueous solution to obtain the extract. Ligusticum chuanxiong extracts volatile oil by steam distillation and makes volatile oil clathrate. Chuanxiong medicinal residues with volatile oil extracted and other raw materials plus water extract. Combining the water extract and volatile oil to concentrate to obtain an extract, mixing the Schisandra extract and the water extracts of other medicinal materials, drying, pulverizing and adding auxiliary materials to obtain the traditional Chinese medicine composition of the present invention. The positive effect of the present invention is scientific compatibility on the basis of traditional Chinese medicine theory, and it has been verified through pharmacodynamic experiments that the composition of the present invention has obvious effects of sedation, calming the mind, inducing sleep and prolonging sleep time. Its above-mentioned effect is obviously better than the selected similar control drug.

Description

Technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to a traditional Chinese medicine composition for nourishing blood and tranquilizing the nerves and a preparation method. Background technique [0002] Insomnia belongs to the categories of "insomnia" and "not sleeping" in traditional Chinese medicine, and can appear in different syndromes of many diseases. With the rapid development of society, the acceleration of the pace of life, the increase of work pressure, and the mental tension of people, there are more and more patients with insomnia, and the incidence rate continues to rise. Foreign epidemiological surveys show that, Approximately 33% of people have experienced sleep disorders every year, and about 17% have severe insomnia. Insomnia seriously affects people's life, work and physical and mental health. [0003] Modern medicine has no effective radical cure for this, but only symptomatic treatment to relieve symptoms. H...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K36/8964A61P25/20A61K35/618A61K35/02
Inventor 徐云修涞贵徐建王婷婷付成国赵俞任晶关丽丹
Owner 吉林修正药业新药开发有限公司
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