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Kit applied to nasopharynx cancer diagnosis, prognosis and treatment effect evaluation

A technology for prognosis judgment and treatment effect, applied in the field of prognosis judgment, treatment effect evaluation kit, and nasopharyngeal carcinoma diagnosis, can solve problems such as lack, and achieve the effects of rapid diagnosis, auxiliary diagnosis and curative effect monitoring

Inactive Publication Date: 2015-05-20
SUN YAT SEN UNIV CANCER CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, there is a lack of a quick, non-invasive, reproducible means of obtaining materials and effective biological indicators for the screening, early diagnosis, curative effect monitoring and prognosis evaluation of nasopharyngeal carcinoma.

Method used

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  • Kit applied to nasopharynx cancer diagnosis, prognosis and treatment effect evaluation
  • Kit applied to nasopharynx cancer diagnosis, prognosis and treatment effect evaluation
  • Kit applied to nasopharynx cancer diagnosis, prognosis and treatment effect evaluation

Examples

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Effect test

Embodiment 1

[0031] Example 1: Research on effective biological indicators for diagnosis and screening of nasopharyngeal carcinoma

[0032] Research purposes:

[0033] Nasopharyngeal carcinoma is highly prevalent in southern China and is associated with EBV (Epstein-Barr virus, EB virus) infection. This study quantitatively detected and analyzed the expression level of EBV-encoded microRNA in nasopharyngeal brush samples, in order to discover new effective biological indicators that can be used for the diagnosis and screening of nasopharyngeal carcinoma.

[0034] experimental design:

[0035] We first verified the abnormally high expression of candidate EBV-associated microRNAs in nasopharyngeal carcinoma clinical biopsy samples; then analyzed the expression levels of candidate microRNAs in nasopharyngeal brush samples and their diagnostic value for nasopharyngeal carcinoma, and employed subjects The area under the curve (AUC) of the operating characteristic curve (ROC) was used to evalu...

Embodiment 2

[0114] A kind of embodiment of nasopharyngeal brush described in the embodiment of the present invention 1, its structure is as Figure 11As shown, the nasopharyngeal brush includes a brush head 1 and a handle, and the handle is composed of a first handle 2, a connecting part 3 and a second handle 4, and the brush head 1 and the first handle 2, the first handle 2 is connected to the second handle 4 through the connecting part 3, the connecting part is a continuously bendable connecting part, and the brush head 1 is made of a plastic rod and arranged on the The nylon flocking swab on the plastic rod is composed of, the length of the plastic rod in the brush head 1 is 15mm, the length of the nylon flocking swab in the brush head 1 is 0.5mm, and the length of the first handle rod 2 The material is plastic, the material of the second handle 4 is plastic, the length of the first handle 2 is 20mm, the diameter is 1.75mm, the length of the second handle 4 is 110mm, the second handle ...

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Abstract

The invention provides a kit applied to nasopharynx cancer diagnosis, prognosis and treatment effect evaluation. The kit is that the expression level of EBV-miR-BART1-5p is detected to effectively reflect the condition of nasopharynx cancer so as to assist the diagnosis and treatment effect monitoring of nasopharynx cancer; in addition, the kit has potential application value in screening of high-risk population suffering from nasopharynx cancer. The kit further comprises a nasopharynx brush through which a sample of a diseased region of nasopharynx can be directly obtained; the nasopharynx brush has the advantages of being painless and free of invasiveness; in addition, cast-off cells obtained through the nasopharynx brush can directly reflect the feature of tumor in the nasopharynx; the sample obtained through the nasopharynx brush and the detection of the expression level of EBV-miR-BART1-5p help clinicians rapidly diagnose nasopharynx cancer; and in addition, the kit greatly assists the therapeutic effect monitor of nasopharynx cancer and follow-up visit.

Description

technical field [0001] The invention relates to a kit, in particular to a kit for nasopharyngeal carcinoma diagnosis, prognosis judgment and treatment effect evaluation. Background technique [0002] Nasopharyngeal carcinoma is a highly invasive and highly metastatic malignancy that is widespread in southern China and Southeast Asia. Although the overall survival rate of patients in the early clinical stage of nasopharyngeal carcinoma reaches about 90%, most of the patients are in the advanced stage of nasopharyngeal carcinoma when they see a doctor, and their survival rate is lower than 50%. Metastasis further contributes to a worse prognosis. Therefore, early diagnosis and timely treatment of nasopharyngeal carcinoma are the key breakthroughs to improve the survival rate and prognosis of patients. How to find and establish simple and reliable biomarkers for the screening and early diagnosis of NPC in high-incidence areas is an urgent problem to be solved clinically. [...

Claims

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Application Information

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IPC IPC(8): C12Q1/68
CPCC12Q1/705C12Q1/6886C12Q2600/118C12Q2600/158C12Q2600/178
Inventor 贾卫华郑小辉张江波李锡照
Owner SUN YAT SEN UNIV CANCER CENT
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