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Chitosan petrolatum gauze and preparation method thereof

A technology of chitosan and vaseline, which is applied in medical science, bandages, absorbent pads, etc., can solve the problem of not having antibacterial properties, and achieve the effect of strengthening anti-infection ability, simple materials, and easy promotion.

Active Publication Date: 2015-05-20
谈伟强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its moisturizing performance is good, but it does not have antibacterial properties because it does not contain antibacterial substances (Xi Tingfei. Progress in Biomaterials (1). Biomedical Engineering and Clinical. 2004, 8(3): 184-9)

Method used

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  • Chitosan petrolatum gauze and preparation method thereof
  • Chitosan petrolatum gauze and preparation method thereof
  • Chitosan petrolatum gauze and preparation method thereof

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0031] The making of embodiment 1 chitosan vaseline gauze

[0032] Add 1.5g of high molecular weight chitosan (molecular weight is 800,000) and 1.5g low molecular weight chitosan (molecular weight of 3,000) into 97g of weakly acidic solution, stir well to obtain 3% chitosan mixture; Immerse the degreased gauze in the chitosan mixture for 24 hours, take out the gauze, and dry it in a drying oven at 60-65°C for 1 hour; soak the dried gauze in melted vaseline paraffin oil (the weight ratio of vaseline to paraffin is 2:1) ) for 1 minute, take it out and drain; then sterilize with ethylene oxide to get 3% chitosan vaseline gauze ( figure 1 , is the superposition of multi-layer chitosan vaseline gauze). The weakly acidic solution here is 1% acetic acid.

Embodiment 2

[0033] Embodiment 2 The making of chitosan vaseline gauze

[0034] Add 0.5g of high molecular weight chitosan (molecular weight of 200,000 and half of 500,000) and low molecular weight chitosan (molecular weight of 50,000 and half of 100,000) to 99g of 1% acetic acid solution, stir well and prepare 1% chitosan mixture; immerse common degreasing gauze in the chitosan mixture for 12 hours, take out the gauze, and dry it in a lyophilizer for 6 hours; soak the dried gauze in vaseline paraffin oil (Vaseline and The weight ratio of paraffin wax is 1:2) for 1 hour, take out and drain, and obtain 1% chitosan vaseline gauze. Here, the chitosan mixture is sterilized by filtration, the vaseline paraffin oil mixture is sterilized by high pressure steam, and the weakly acidic solution is 0.5% sorbic acid.

Embodiment 3

[0035] Embodiment 3 The making of chitosan vaseline gauze

[0036] Add 2g of high molecular weight chitosan (1g each with molecular weights of 200,000 and 800,000) and 3g of low molecular weight chitosan (1g each with molecular weights of 3,000, 10,000 and 50,000) into 95g of weakly acidic solution, stir well Prepare a 5% chitosan mixture; immerse ordinary degreasing gauze in the chitosan mixture for 48 hours, take out the gauze, and dry it in a drying oven at 60~65°C for 3 hours; dip the dried gauze into the melted Vaseline paraffin oil (weight ratio of vaseline and paraffin is 1:1) for 30 minutes, take out and drain; then sterilize with ethylene oxide to obtain 5% chitosan vaseline gauze. The weakly acidic solution here is 2% citric acid.

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Abstract

The invention provides chitosan petrolatum gauze. The chitosan petrolatum gauze is prepared according to the following steps: dissolving a chitosan mixture in a weak acid solution to prepare a chitosan mixed solution; subsequently soaking medical gauze in the chitosan mixed solution to prepare chitosan gauze; soaking the chitosan gauze in a melt petrolatum and paraffin oil mixed solution to prepare the chitosan petrolatum gauze of which the concentration is 1% to 5%. The chitosan petrolatum gauze is a novel medical dressing which is prepared in combination with the advantages of the chitosan and the traditional petrolatum gauze, anti-bacterial, capable of retaining moisture, stopping bleeding and prompting healing of wounds, and low in price. The chitosan petrolatum gauze provided by the invention has the effect of enhancing the original moisture retention properties and also has anti-bacterial properties and unique properties of stopping bleeding, relieving pain, prompting the healing of wounds, reducing formation of scars and the like. The chitosan petrolatum gauze is free of irritation to the human body, free of obvious toxicity, rich in raw materials and low in preparation cost and can be widely applied to wound surface treatment.

Description

technical field [0001] The invention belongs to the field of medical dressings, in particular to a chitosan vaseline gauze and a preparation method thereof. Background technique [0002] With the in-depth research on wound healing, people realize that the purpose of using dressings is far more than just to cover the wound, and the dressing must also promote wound healing (Yu Yusheng, Tan Weiqiang. The formation mechanism and treatment of scars. "10000 scientific problems Medical Volume". Science Press, 2011.8, Eleventh Five-Year Plan. 442-4; Tan WQ (谈伟强), Gao ZJ, Xu JH, Yao HP. Inhibiting scar formation in vitro and in vivo by adenovirus-mediated mutant Smad4 : a preliminary report. Exp Dermatol. 2011, 20(2): 119-24). The previous point of view believed that a dry environment should be created for the wound as much as possible to reduce the chance of infection and facilitate wound healing. However, research in recent years has shown that wounds heal faster in a moist envi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/34A61L15/44A61L15/42
Inventor 谈伟强黄春兰张利云
Owner 谈伟强
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