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Microwell plate

A technology of micro-orifice plate and open side, which is applied in the field of micro-orifice plate, can solve the problems such as difficult formation of cell agglutination, and achieve the effect of good formation, ensured well capacity and sufficient well capacity

Inactive Publication Date: 2015-05-13
SUMITOMO BAKELITE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in such a well shape, since the bottom of the well is flat, it is difficult to form uniform cell aggregates.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Injection molding using transparent polystyrene resin (manufactured by PS Japan Co., Ltd., HF77) and transparent polystyrene resin mixed with 15% white pigment titanium dioxide (manufactured by SUMIKA COLORCO.,LTD.) Form two types of 384-well microplates, transparent and white.

[0057] The shape of the obtained microplate was 127.7 mm in width, 85.5 mm in length, and 14.4 mm in height.

[0058] In addition, the shape of each hole is as image 3 As shown, the opening is a quadrilateral with a side of 3.3 mm, a depth of 12 mm, a radius of curvature of the bottom of 1.5 mm, and a pore volume of 108.4 μL.

[0059] In addition, the depth of the opening side portion 41 is 8.8 mm, the total depth of the bottom side portion 42 and the transition portion 43 is 3.2 mm, and the depth ratio is 15:4.

[0060] The obtained plate was subjected to plasma treatment (oxygen plasma for 10 minutes) using a plasma treatment apparatus (SERIES 7000 manufactured by Branson / IPC Co., Ltd.) to...

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PUM

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Abstract

The purpose of the present invention is to provide a microwell plate, which is capable of favorably forming cell aggregates and which secures an adequate well volume. Provided is a microwell plate equipped with wells that have openings that open on one surface, wherein: the wells demarcate spaces formed from the openings towards the interior of the microwell plate and the spaces have an opening end portion, a bottom end portion formed from the opening end portion towards the interior of the microwell plate, and a transitional portion (43) for smoothly connecting the opening end portion (41) to the bottom end portion (42); the transverse cross-section of the opening end portion has a polygonal shape; and the bottom end portion is formed so that the transverse cross-sectional area decreases gradually towards the interior.

Description

technical field [0001] The invention relates to a microporous plate. Background technique [0002] In recent years, screening for drug efficacy evaluation and research on differentiation-inducing factors have been actively carried out. In this study, various cell aggregates were used for evaluation. Therefore, there is a need for a culture method for efficiently forming cell aggregates. [0003] In addition, in evaluations such as screening, it is necessary to process multiple samples quickly and at once. Therefore, there is a need for a culture vessel capable of forming and evaluating a large number of cell aggregates. [0004] Microplates provided with many wells can be used for such purposes. Among microplates, there are 96-well, 384-well, and 1536-well microplates on the market, which can handle a large number of samples. [0005] However, microplates provided with many wells have problems as follows. Since the shape and size of microplates are standardized (ANSI / S...

Claims

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Application Information

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IPC IPC(8): C12M1/00C12M1/32
CPCC12M23/12B01L3/5085B01L2300/0829B01L2300/0851B01L2300/0858G01N33/4833G01N33/5011G01N33/5067G01N2500/10
Inventor 塚田亮平大久保春男
Owner SUMITOMO BAKELITE CO LTD
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