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Inspection methods for pecvd coatings

A coating and coating technology, applied in the field of PECVD coating inspection, can solve problems such as contaminating drugs and affecting drug stability.

Inactive Publication Date: 2015-05-13
SI02 MEDICAL PRODS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These compounds can contaminate the drug and / or negatively affect the stability of the drug

Method used

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  • Inspection methods for pecvd coatings
  • Inspection methods for pecvd coatings
  • Inspection methods for pecvd coatings

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0868] Example 1 - From CO 2 Purged uncoated and CO 2 Coated molded COP vials of CO 2 Infrared detection of outgassing

[0869] equipment and materials

[0870] (1) Inifiocon HLD-5000CO with 1 / 8 brass tubing elbow extension from the sample port (with a flange to hold the vial in place) 2 monitor.

[0871] (2) There is CO inside 2 Plexiglass box for the monitor with an opening to pass the vial from the purge unit to the CO 2 Monitor sample port.

[0872] (3) Has a vial adapter capable of achieving 25 psi CO on the inner wall 2 Pressure type 3 (3-up) purge device

[0873] (4) SiO x Type 4 coater (name / designation?) - CV Holdings, manufactures vial disc adapters

[0874] (5) Uncoated COP 5mL Molded Vials

[0875] (6) from SiO x SiO coating machine x (Standard 20 second plasma coating) Coated COP 5mL molded vials

[0876] General procedure:

[0877] Will uncoated or SiO x The coated vial was placed into one of the three vial adapters on the purge unit, vacuumed fo...

example 2

[0894] to CO 2 Outgassing Measurements of Inflated, Uncoated COC Tubes

[0895] VI.B. Perform this initial test to determine CO 2 Can be charged into a COC to significantly increase its ATC bleed flow rate. Thirty uncoated COC tubes were fabricated according to the protocol used to form COC tubes. in CO 2 Before inflation, test the tubes for deflation following the protocol for testing deflation. Flow rate was measured using an ATC with a 14 μg / min sensor. in CO 2 The ATC flow rates prior to inflation are shown in Table A. After making this measurement on each tube, the CO 2 The protocol for filling blood collection tubes will be CO 2 Fill the same tube with CO for 10 minutes 2 inflation time. The rate was measured again in the same manner and the results are again reported in Table A.

[0896] Refer to Table A, in CO 2 The average deflation flow rate of the COC tube before inflation was 1.43 μg / min. in CO 2 The average deflation flow rate of the COC tube after i...

example 3

[0900] CO 2 Inflation time versus deflation rate

[0901] In this instance, CO 2 The length of inflation time is varied to show its effect on deflation. The ATC test time was also increased to five minutes, so the results of this test are not directly comparable to those of Example 2. The test is otherwise similar to the "CO 2 After inflation" test was carried out.

[0902] These results are presented in Table B, which shows that the deflation flow rate increases with increasing inflation time, although the increase in inflation per minute flow rate is smaller with increasing inflation time.

[0903] Table B: CO 2 Influence of Inflation Time on ATC Flow Rate

[0904]

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Abstract

A method for inspecting the product of a coating process is provided. In certain embodiments, the release of at least one volatile species from the coated surface into the gas space adjacent to the coated surface is measured and the result is compared with the result for at least one reference object measured under the same test conditions. Microbalance weighing methods are also disclosed to detect and distinguish among PECVD coatings. Thus the presence or absence of the coating, and / or a physical and / or chemical property of the coating can be determined. The method is useful for inspecting any coated articles, e.g. vessels. Its application on the inspection of PECVD coatings made from organosilicon precursors, especially of barrier coatings, is also disclosed.

Description

[0001] Priority is hereby claimed to U.S. Provisional Serial No. 61 / 644,990, filed May 9, 2012. This application is hereby incorporated by reference in its entirety. [0002] U.S. Provisional Serial No. 61 / 177,984 filed May 13, 2009; 61 / 222,727 filed July 2, 2009; 61 / 213,904 filed July 24, 2009; 61 / 234,505; 61 / 261,321 filed November 14, 2009; 61 / 263,289 filed November 20, 2009; 61 / 285,813 filed December 11, 2009; 61 / 298,159 filed January 25, 2010; 61 / 299,888, filed January 29, 2010; 61 / 318,197, filed March 26, 2010; 61 / 333,625, filed May 11, 2010; and 61 / 413,334, filed November 12, 2010; and US Serial No. 12 / 779,007, filed May 12, 2010; incorporated herein by reference in its entirety. [0003] The following European patent applications are also hereby incorporated by reference in their entirety: EP10162755.2 filed 12 May 2010; EP10162760.2 filed 12 May 2010; EP10162756.0 filed 12 May 2010; EP10162758.6, filed May 12, 2010; EP10162761.0, filed May 12, 2010; and EP10162757.8,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M5/31A61B5/15C23C16/52G01B21/08G01G7/02G01B7/06G01N15/08
CPCA61B5/1405A61B5/1438A61B5/15003A61B5/150274A61B5/154A61M5/3129C23C16/52G01B21/08G01N15/082G01N2033/0096A61M2005/3131G01G19/00G01G19/414A61B5/150229A61B5/150351A61B5/150992A61B5/150236A61B5/150244A61B5/153C23C16/50G01N21/8422G01N2021/8427G01N2201/06113
Inventor J·T·费尔特斯T·E·费斯克R·S·阿伯拉姆斯J·弗古森J·R·弗里德曼R·J·潘格伯恩P·J·萨高纳C·维卡特
Owner SI02 MEDICAL PRODS
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