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Tissue-engineered bone and cartilage double-chamber cultivation system

A tissue engineering bone and osteochondral technology, which is applied in tissue cell/virus culture devices, biochemical instruments, biochemical equipment and methods, etc., can solve the problems that bone and cartilage cannot be cultured at the same time, shorten the treatment cycle and improve the quality , the effect of reducing the disability rate

Inactive Publication Date: 2015-05-06
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In view of this, the object of the present invention is to provide a dual-chamber culture system for tissue engineering osteochondral to solve the problem that bone and cartilage cannot be cultured simultaneously in the prior art

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  • Tissue-engineered bone and cartilage double-chamber cultivation system
  • Tissue-engineered bone and cartilage double-chamber cultivation system

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Embodiment Construction

[0023] The preferred embodiments of the present invention will be described in detail below with reference to the accompanying drawings.

[0024] Such as figure 1 and figure 2 As shown, the tissue engineering osteochondral dual-chamber cultivation system of this embodiment is composed of a bone cultivation circulation system 2 and a cartilage cultivation circulation system 3 that are respectively connected to the osteochondral double-chamber cultivation chamber 1 and are independent of each other. The cavity cultivation chamber 1 is composed of an outer layer chamber 6, an inner layer chamber 7, and an osteochondral bionic integrated support 8. The outer layer chamber 6 and the inner layer chamber 7 are separated from each other by the osteochondral bionic integrated support 8 to form independent The bone cultivation chamber 4 and the cartilage cultivation chamber 5, the bone cultivation circulation system 2 communicates with the bone cultivation chamber 4 to form an indepen...

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Abstract

The invention discloses a tissue-engineered bone and cartilage double-chamber cultivation system, and belongs to the technical field of cultivation devices. The tissue-engineered bone and cartilage double-chamber cultivation system consists of a bone cultivation circulating system and a cartilage cultivation circulating system which are communicated with an bone and cartilage double-cavity cultivation chamber and are independent, wherein the bone and cartilage double-cavity cultivation chamber consists of an outer layer cavity, an inner layer cavity and a bone and cartilage biomimetic integrated bracket; the outer layer cavity and the inner layer cavity are isolated from each other through the bone and cartilage biomimetic integrated bracket to form a bone cultivation chamber and a cartilage cultivation chamber which are independent; the bone cultivation circulating system is communicated with the bone cultivation chamber; the cartilage cultivation circulating system is communicated with the cartilage cultivation chamber. Through the arrangement of the bone and cartilage double-cavity cultivation chamber formed at the same time when cultures are formed, cultivation of bone and cartilage regeneration is carried out at the same time, so that the cultivation efficiency and the quality can be greatly improved; the treating period for a patient suffering from bone and cartilage coloboma is shortened, the pain and the economical burden of the patient can be reduced, and the tissue-engineered bone and cartilage double-chamber cultivation system is extremely high in economical value.

Description

technical field [0001] The invention belongs to the technical field of culture devices, in particular to a dual-chamber culture system for tissue engineering osteochondral. Background technique [0002] Osteochondral defects at the joint end caused by trauma or bone disease are common clinically, seriously affecting the function of the affected limb and the quality of life of the patient, and have become one of the main causes of physical disability. Existing clinical treatments, including autologous or allogeneic osteochondral transplantation, artificial joint replacement, etc., have obvious defects; the rapid development of tissue engineering technology in recent years provides a new method for the realization of osteochondral regeneration and repair. Regarding the research on tissue-engineered osteochondral tissue, the animal experiments from the preliminary exploration of the feasibility of "layered construction" to "integrated construction" have achieved phased results,...

Claims

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Application Information

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IPC IPC(8): C12M3/00
CPCC12M21/08C12M23/58C12M29/02
Inventor 王富友陈诚龚啸元曾伟南杨柳
Owner THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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