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Phosphoric acid esterification snakegourd peel polysaccharide and medical application thereof

A technology of trichosanthes peel and phosphate ester, which is applied in the direction of medical formula, medical preparations containing active ingredients, drug combination, etc., to achieve the effect of no toxic side effects, significant functions, simple and economical methods

Inactive Publication Date: 2015-05-06
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no public documents at home and abroad that mention the modification of Trichosanthes bark polysaccharides by phosphorylation to modify them into phosphorylated polysaccharides, and reports on their application in the preparation of anti-aging drugs

Method used

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  • Phosphoric acid esterification snakegourd peel polysaccharide and medical application thereof
  • Phosphoric acid esterification snakegourd peel polysaccharide and medical application thereof
  • Phosphoric acid esterification snakegourd peel polysaccharide and medical application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0021] 1. Preparation of Gualou Bark Polysaccharide (TPP-1):

[0022] This embodiment first prepares TPP-1 according to the following steps:

[0023] The melon rind is cleaned, dried and pulverized to obtain melon rind powder; petroleum ether and anhydrous ethanol are sequentially added to the melon rind powder, refluxed for 8 hours for preliminary degreasing and decolorization, and then naturally dried to obtain melon rind dry powder ; According to the volume ratio of the dry powder of Gualou rind to distilled water is 1:35 mg / mL, add distilled water to the dry powder of Gualou rind, and extract by ultrasonic-assisted water bath extraction method with ultrasonic temperature of 60 °C, ultrasonic time of 30 min, and ultrasonic power of 300 W. 3 times, the filter residue was removed by filtration, and the filtrate was combined to obtain the melon rind extract;

[0024] Use a rotary evaporator (Shanghai Yarong) to concentrate the extract of the cucurbita rind, after centrifugati...

Embodiment 2

[0082] This embodiment first prepares TPP-1 according to the following steps:

[0083] Wash the melon rind, dry it, pulverize it, add petroleum ether and ethanol respectively, reflux for 10 hours to carry out preliminary degreasing and decolorization, and dry at 60°C to obtain melon rind dry powder; The volume ratio is 1:30 mg / mL, and distilled water is added to the dry powder of Gulou rind, and the ultrasonic temperature is 55 ° C, the ultrasonic time is 40 min, and the ultrasonic power is 350 W. The ultrasonic-assisted water bath extraction method is extracted 3 times; the filter residue is removed by filtration to obtain the guarlou peel extraction. liquid;

[0084] Concentrate the extract of Gualou rind by rotary evaporation, after centrifugation, add 3 times the volume of 95% ethanol, and precipitate at 4°C for 12h; then 4000r·min -1 Centrifuge for 15 min, and pour off the supernatant to obtain alcohol-precipitated polysaccharide; use distilled water to dissolve alcohol-...

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PUM

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Abstract

The invention discloses phosphoric acid esterification snakegourd peel polysaccharide and a medical application thereof. The phosphoric acid esterification snakegourd peel polysaccharide is characterized by being prepared by performing phosphoric acid esterification modification on snakegourd peel polysaccharide by using sodium tripolyphosphate and sodium trimetaphosphate. The phosphoric acid esterification snakegourd peel polysaccharide disclosed by the invention has a significant anti-ageing function, does not have toxic or side effects, cannot cause damages to internal organs, and can be used for preparing anti-ageing medicaments.

Description

technical field [0001] The invention relates to a modified Fructus Fructus Polysaccharide, in particular to a phosphate esterified Citrus Fructus Polysaccharide and its medicinal use. Background technique [0002] Aging is a process in which the functions of various tissues and organs of the body undergo degenerative changes with age. According to the Journal of Ethnopharmacology (Journal of Ethnopharmacology, 2010, 132:512-517), the increase of active free radicals can damage the tissues or cells of the body. Accelerates the aging process of the body. With the acceleration of population aging trend in most countries in the world, more and more scholars focus on the research of anti-oxidant and anti-aging agents in the body. Therefore, it is of great significance to find anti-aging drugs without toxic and side effects from natural products. [0003] Plant polysaccharides are biological macromolecules formed by the condensation of multiple monosaccharide molecules, and are...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61K31/715A61P39/06
Inventor 叶明荆莲艳杨柳徐平张敏
Owner HEFEI UNIV OF TECH
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