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A kind of phosphorylated trichosanthes bark polysaccharide and its medical application

A technology of trichosanthes peel and phosphate ester, which is applied in the direction of drug combination, anti-toxic agent, etc., to achieve the effect of simple and economical method, significant function, and no toxic and side effects

Inactive Publication Date: 2017-01-11
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no public documents at home and abroad that mention the modification of Trichosanthes bark polysaccharides by phosphorylation to modify them into phosphorylated polysaccharides, and reports on their application in the preparation of anti-aging drugs

Method used

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  • A kind of phosphorylated trichosanthes bark polysaccharide and its medical application
  • A kind of phosphorylated trichosanthes bark polysaccharide and its medical application
  • A kind of phosphorylated trichosanthes bark polysaccharide and its medical application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] One, the preparation of trichosanthes bark polysaccharide (TPP-1):

[0022] This embodiment first prepares TPP-1 according to the following steps:

[0023] Trichosanthes peel was cleaned, dried and crushed to obtain Trichosanthes peel powder; Petroleum ether and absolute ethanol were added to Trichosanthes peel powder in turn, refluxed for 8 hours for preliminary degreasing and decolorization, and then dried naturally to obtain Trichosanthes peel powder ;According to the volume ratio of the mass of Trichosanthes rind dry powder to distilled water as 1:35mg / mL, add distilled water to Trichosanthes trichosanthes dry powder, and use the ultrasonic-assisted water-bath extraction method with ultrasonic temperature 60°C, ultrasonic time 30min, and ultrasonic power 300W 3 times, filter to remove the filter residue, combine the filtrate to obtain the Trichosanthes bark extract;

[0024] Use a rotary evaporator (Shanghai Yarong) to concentrate the extract of Trichosanthes rind,...

Embodiment 2

[0082] This embodiment first prepares TPP-1 according to the following steps:

[0083] Trichosanthes rind was cleaned, dried and crushed, respectively added petroleum ether and ethanol, refluxed for 10 hours for preliminary degreasing and decolorization, and dried at 60°C to obtain dried Trichosanthes rind powder; The volume ratio is 1:30mg / mL, add distilled water to the dry powder of Trichosanthes pipifolia, use ultrasonic temperature 55 ℃, ultrasonic time 40min, ultrasonic power 350W ultrasonic assisted water bath extraction method to extract 3 times; filter and remove the filter residue to obtain Trichosanthes piquant extraction liquid;

[0084] Concentrate the Trichosanthes rind extract by rotary evaporation, centrifuge, add 3 times the volume of 95% ethanol, and alcohol precipitate at 4°C for 12h; then 4000r·min -1 Centrifuge for 15 minutes, pour off the supernatant to obtain the alcohol-precipitated polysaccharide; use distilled water to dissolve the alcohol-precipitate...

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Abstract

The invention discloses phosphoric acid esterification snakegourd peel polysaccharide and a medical application thereof. The phosphoric acid esterification snakegourd peel polysaccharide is characterized by being prepared by performing phosphoric acid esterification modification on snakegourd peel polysaccharide by using sodium tripolyphosphate and sodium trimetaphosphate. The phosphoric acid esterification snakegourd peel polysaccharide disclosed by the invention has a significant anti-ageing function, does not have toxic or side effects, cannot cause damages to internal organs, and can be used for preparing anti-ageing medicaments.

Description

technical field [0001] The invention relates to a modified trichosanthes peel polysaccharide, in particular to a phosphorylated trichosanthes polysaccharide and its medical application. Background technique [0002] Aging is a process in which the functions of various tissues and organs of the body undergo degenerative changes with age. According to "Journal of Ethnopharmacology" (Journal of Ethnopharmacology, 2010, 132:512-517), the increase of active free radicals will damage the tissues or cells of the body. When the damage caused by free radicals accumulates beyond the body's repair capacity, it will Accelerate the aging process of the body. With the acceleration of the aging trend of the population in most countries in the world, more and more scholars are focusing on the study of anti-oxidation and anti-aging agents. Therefore, it is of great significance to find anti-aging drugs without toxic side effects from natural products. [0003] Plant polysaccharides are bi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/00A61K31/715A61P39/06
Inventor 叶明荆莲艳杨柳徐平张敏
Owner HEFEI UNIV OF TECH
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