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Method for simultaneously preparing gram-grade high-purity tyrosol, renulatin and salidroside from rhodiola crenulata

A technology of Rhodiola daponica and Rhodiola daponica is applied in the preparation of sugar derivatives, chemical instruments and methods, preparation of organic compounds, etc. high rate effect

Active Publication Date: 2015-04-29
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Most of the previous literature reports are the preparation method of one of the compounds of tyrosol, triflorin and salidroside, and the preparation process is relatively cumbersome

Method used

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  • Method for simultaneously preparing gram-grade high-purity tyrosol, renulatin and salidroside from rhodiola crenulata
  • Method for simultaneously preparing gram-grade high-purity tyrosol, renulatin and salidroside from rhodiola crenulata
  • Method for simultaneously preparing gram-grade high-purity tyrosol, renulatin and salidroside from rhodiola crenulata

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 Extraction of effective parts of Rhodiola rosea

[0029] 1. Experimental instruments and materials

[0030] The medicinal material of Rhodiola was identified by Professor Wu Qinan of Nanjing University of Traditional Chinese Medicine as the dry root and rhizome of Rhodiola crenulata (Hook.f.et Thoms) H.Ohba; D-101, HPD-100, HPD- 450 macroporous adsorption resin (Tianjin Pesticide General Factory), AB-8, HZ-801 macroporous resin (Nankai University Chemical Plant); column chromatography silica gel (Qingdao Ocean Chemical Plant); methanol (chromatographically pure, Tedia, the United States); water (re-distilled, self-made); Methanol, phosphoric acid, medicinal 95% ethanol (Nanjing Chemical Reagent Co., Ltd.); Agilent 1100 high performance liquid chromatography (Agilent, USA), equipped with autosampler, quaternary pump, ELSD detector ; MWD detector; AE240 electronic analytical balance (Mettler, Switzerland).

[0031] 2. Methods and results

[0032] 2.1 Chroma...

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Abstract

The invention provides a method for simultaneously preparing gram-grade high-purity tyrosol, renulatin and salidroside from rhodiola crenulata. With rhodiola crenulata as a raw material, the gram-grade high-purity tyrosol, renulatin and salidroside from rhodiola crenulata are prepared from such steps as ethanol extraction, alcohol precipitation, filtration, macroporous adsorption resin separation and silica gel column purification. The method is simple, convenient and quick, and provides a new way of thinking for the mass preparation of the three compounds.

Description

technical field [0001] The invention relates to a preparation method of active ingredients in Rhodiola rosea. Background technique [0002] Rhodiola is the dry root and rhizome of Rhodiola crenulata (Hook.f.et Thoms) H.Ohba, a plant of Crassulaceae. It can replenish qi and activate blood, dredge the meridians and relieve asthma. It is often used for qi deficiency and blood stasis, chest pain and heartache, stroke hemiplegia, fatigue and asthma embolism. Its main chemical components are flavonoids, glycosides and aglycones, organic acids and so on. Among them, salidroside (salidroside) and its aglycone tyrosol (tyrosol) have a wide range of pharmacological effects, and are often used for neuroprotection and cardiovascular protection, and other literature reports have anti-inflammatory, anti-tumor, and immunomodulatory effects . A certain concentration of crenulatin has the effect of anti-apoptosis of rat lung microvascular endothelial cells, and has a bidirectional regulat...

Claims

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Application Information

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IPC IPC(8): C07C39/11C07C37/70C07H15/18C07H15/10C07H1/08
CPCC07C37/004C07H1/08C07H15/10C07H15/18C07C39/11
Inventor 萧伟罗鑫王雪晶黄文哲谢雪倪付勇王振中
Owner JIANGSU KANION PHARMA CO LTD
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