Preparation method of spermacoce latifolia triterpenoids and application of spermacoce latifolia triterpenoid in preparation of glycosidase inhibitor medicine

Abstract

The invention provides a preparation method of spermacoce latifolia triterpenoids and an application of the spermacoce latifolia triterpenoids in preparation of a glycosidase inhibitor medicine. Six compounds for intensively inhibiting the activity of alpha-glycosidase provided by the invention are natural compounds which are high in safety, and can be naturally degraded rapidly without a residue in the environment. The compounds can be separated from plant materials such as spermacoce latifolia; the plant materials are abundant in source; and the preparation process is easy to operate. Monomers of the six compounds are relatively stable and easy to store; the alpha-glycosidase inhibiting activity is obviously higher than that of clinical medicine acarbose; and the compounds are extremely likely to be further developed into the effective and safe alpha-glycosidase inhibitor medicines for preventing and treating type 2 diabetes mellitus, and have relatively good prospects.

Description

technical field [0001] The invention belongs to the field of natural medicinal chemistry, and in particular relates to six triterpenoids, namely mesembryanthemoidigenic acid (1), 29-hydroxyhederagenin (2), 3β, 6β-dihydroxy-olean-12-ene-28-oic acid (3), scutellaric acid (4), arjunic acid (5), 3β, 6β, 23-trihydroxy-olean-12-en-28-oic acid (6) or pharmaceutically acceptable salts thereof in the preparation of glycosidase inhibitors or drugs applications, and their preparation methods. Background of the invention [0002] Diabetes is a clinically common endocrine and metabolic disorder disease, which has an important correlation with the annual increase in cardiovascular diseases and cancers, and is an important killer of human health. At present, the incidence of diabetes is increasing worldwide. In my country, the prevalence of diabetes is more than 100 million, and it shows a trend of increasing year by year. Diabetes is causing more and more serious losses to our people's ...

AI Technical Summary

Problems solved by technology

[0004] Six kinds of triterpenoid mesembryanthemoidigenic acid (1), 29-hydroxyhederagenin (2), 3β,6β-dihydroxy-olean-12-ene-28-oic acid (3), scutellaric acid (4), arjunic acid (5), 3β, 6β, 23-trihydroxy-olean-12-en-28-oic acid (6) were isolated from other plants (see literature: Magina et al., Quim Nova, 2012, 35:1184-1188; Huu et al., J Chem, 2007, 45:363-367; Kuo et al., Chem Pharm Bull, 1988, 36:3619-3622; Ponou et al., Chem Biodivers, 2011, 8:1301-1309; Lavaud et al. al., Phytochemistry, 2001,57:469-478; Khan et al., J Nat Prod, 1993,56:2163-2165), their chemical structural formula is shown in the following formula (I), and these compounds have not been seen so far It has been reported to have glycosidase inhibitor activity, and there is no report on its isolation from Spermacoce latifolia plants

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