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Liquid medicine having carbon dioxide dissolved therein, and therapeutic method using same

A carbon dioxide, treatment method technology, applied in chemical instruments and methods, medical preparations containing active ingredients, drug combinations, etc., can solve problems such as side effects, flap transplantation failure, and difficult radical cure, and achieve the effect of reducing side effects.

Inactive Publication Date: 2015-03-18
NEOCHEMIR INC +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] (2) Failure of skin grafts, skin flaps, etc.;
For treatment, non-steroidal anti-inflammatory drugs or steroidal anti-inflammatory drugs, immunosuppressants, etc., or plasma exchange therapy are used, but each method is difficult to cure and has side effects

Method used

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  • Liquid medicine having carbon dioxide dissolved therein, and therapeutic method using same
  • Liquid medicine having carbon dioxide dissolved therein, and therapeutic method using same
  • Liquid medicine having carbon dioxide dissolved therein, and therapeutic method using same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0164] Connect the silicone rubber tube to the regulator of the liquefied carbon dioxide high-pressure cylinder, and connect the injection needle (thick 18G) to the silicone rubber tube. The injection needle was inserted into the rubber stopper of a plastic bag containing physiological saline (250ml; pH6.34), and at the same time, in order to discharge excess carbon dioxide, another needle was used to pierce the upper part of the plastic bag without physiological saline to Carbon dioxide was bubbled at a rate of 1 liter / min for 5 minutes to prepare carbon dioxide-dissolved physiological saline (pH 4.62).

Embodiment 2

[0166] To 5 ml of venous blood collected from the forearm of a 29-year-old man using a vacuum blood collection tube, 0.5 ml of a 3.8% sodium citrate aqueous solution for preventing blood coagulation was added to prepare a solution for dissolving carbon dioxide (pH 7.21). Connect the silicone rubber tube to the regulator of the liquefied carbon dioxide high-pressure cylinder, and connect the injection needle (thick 18G) to the silicone rubber tube. The injection needle was inserted into the aforementioned blood collection tube, and carbon dioxide was bubbled at a rate of 0.5 liter / minute for 3 minutes to obtain carbon dioxide-dissolved blood (pH 6.83).

Embodiment 3

[0168] Connect the silicone rubber tube to the regulator of the liquefied carbon dioxide high-pressure cylinder, and connect the injection needle (thick 18G) to the silicone rubber tube. The injection needle was inserted into a plastic bag (100 ml; product name Intralipos, manufactured by Otsuka Pharmaceutical Works, pH 7.21) containing a fat emulsion containing 20% ​​of refined soybean oil on a rubber stopper, and at the same time, in order to discharge excess carbon dioxide, another A needle was pierced into the upper portion of the plastic bag without the fat emulsion, and carbon dioxide was bubbled at a rate of 1 liter / min for 5 minutes to prepare a fat emulsion (pH 4.67) in which carbon dioxide was dissolved.

[0169]From the above results, it can be seen that the liquid medicine of the present invention containing a liquid dissolved in carbon dioxide and administered by liquid injection means, and the treatment method of the present invention using a liquid medicine conta...

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Abstract

A tumor can be regressed or eradicated with little adverse side effects using a liquid medicine according to the present invention, which comprises a liquid having carbon dioxide dissolved therein and is to be administered using a liquid injection means, or by a therapeutic method according to the present invention, which uses a liquid medicine to be administered using a liquid injection means and comprising a liquid having carbon dioxide dissolved therein. When the liquid medicine according to the present invention, which comprises a liquid having carbon dioxide dissolved therein and is to be administered using a liquid injection means, and the therapeutic method according to the present invention, which uses a liquid medicine to be administered using a liquid injection means and comprising a liquid having carbon dioxide dissolved therein, are used in combination with a surgical therapy, a chemotherapy, a radiation therapy or an immunotherapy for tumors, the effect can be potentiated or adverse side effects can be reduced compared with a case in which each of the therapies is carried out singly or a multimodal treatment of the therapies is carried out.

Description

【Technical field】 [0001] The present invention relates to a liquid medicine containing a liquid dissolved in carbon dioxide and administered by means of liquid injection, and a treatment method using the liquid medicine, wherein the liquid medicine is a liquid medicine containing a liquid dissolved in carbon dioxide and administered by means of liquid injection . 【Background technique】 [0002] Patent Document 1 describes that carbon dioxide is effective for the symptoms and the like shown in roughly the following (1) to (10) (see Patent Document 1). [0003] (1) Tinea pedis, insect bites, atopic dermatitis, nummular eczema, dry skin, seborrheic eczema, urticaria, prurigo, housewife eczema, acne vulgaris, impetigo, folliculitis, Carbuncle, furunculosis, cellulitis, pyoderma, psoriasis, pityriasis, palmoplantar keratoderma, lichen, pityriasis, wound, burn, chap, erosion, chilblain, etc. Itching; decubitus ulcers, wounds, burns, angular cheilitis, stomatitis, skin ulcers, ch...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/00A61K9/00A61P35/00A61P37/06A61P37/02C01B32/50
CPCA61K9/0019A61K33/00A61K33/08A61K45/06A61P35/00A61P37/00A61P37/02A61P37/06A61K2300/00A61N5/10
Inventor 田中雅也三轮雅彦藤井正彦山口雅人
Owner NEOCHEMIR INC
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