A kind of pharmaceutical composition for treating myocardial infarction and its application

A technique for myocardial infarction and composition, which is applied in the field of pharmaceutical compositions for the treatment of myocardial infarction, can solve the problems of inability to improve and reverse the symptoms of myocardial infarction in patients, and achieve good clinical application prospects, good activity for treating myocardial infarction, and comprehensive drug effects. Effect

Active Publication Date: 2017-11-21
安佰海
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing traditional Chinese medicine preparations still cannot improve and reverse the symptoms of myocardial infarction patients, and the long-term safety issues are still worthy of consideration

Method used

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  • A kind of pharmaceutical composition for treating myocardial infarction and its application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] The preparation of embodiment 1 oral liquid

[0015] Weigh 0.15kg of palm leaf, 0.25kg of Sophora japonica, 0.07kg of Chinese jujube root, 0.08kg of Araceae, 0.04kg of Rhizoma chinensis, 0.04kg of rhubarb, 0.08kg of Gastrodia elata, 0.04kg of magnolia officinalis, and 0.11kg of malt. For the first time, the volume of water added for the first time is 12 times the total mass of medicinal materials (L / kg), boiled and then decocted on low heat for 2 hours; Decoct for 1.5 hours, combine the decoction, concentrate under reduced pressure at 0.08MPa and 70°C until the relative density is about 1.15 at 70°C, add 95% (v / v) ethanol to make the alcohol content reach 80% (v / v), Stir, stand overnight, filter, and concentrate the filtrate under reduced pressure at 0.08MPa and 65°C to a relative density of about 1.15 at 65°C, and add water and sucrose to prepare an oral liquid.

Embodiment 2

[0016] The preparation of embodiment 2 granules

[0017] Weigh 0.30kg of palm leaf, 0.50kg of Sophora japonica, 0.14kg of Chinese jujube root, 0.15kg of Araceae, 0.08kg of Rhizoma chinensis, 0.08kg of rhubarb, 0.15kg of Gastrodia elata, 0.08kg of magnolia officinalis, and 0.22kg of malt. The first time, the volume of water added for the first time was 10 times the total mass of medicinal materials (L / kg), decocted for 2 hours; the volume of water added for the second time was 8 times the total mass of medicinal materials (L / kg), decocted for 1.5 hours, combined Decoction, 0.08MPa, concentrated under reduced pressure at 70°C to a relative density of about 1.15 at 70°C, add 95% (v / v) ethanol to make the alcohol content reach 80% (v / v), stir, and stand overnight, Filtrate, and concentrate the filtrate under reduced pressure at 0.08MPa and 65°C to obtain an extract with a relative density of about 1.20 at 65°C. Put the extract in a stainless steel plate, dry it in vacuum (below 60...

Embodiment 3

[0018] Embodiment 3 The curative effect research of Chinese medicine on animal model of acute myocardial infarction

[0019] Healthy Wistar rats, male, weighing 200-220 g, were randomly divided into a sham operation group, a model control group, and a high-dose and low-dose group of traditional Chinese medicine, with 12 rats in each group. After the test started, the animal model of acute myocardial infarction was reproduced as follows: the rat was anesthetized by intraperitoneal injection of 10 mL / kg of 3.5% chloral hydrate, and fixed in a supine position. An incision was made at the 4th and 5th intercostals on the left side of the rat, the chest cavity was opened, the pericardium was torn apart, the heart was extruded by gentle pressure on the thorax, the left anterior descending coronary artery was ligated 2 mm below the left atrial appendage with a No. 0 surgical thread, and the heart was immediately put back Chest cavity, close the incision, and suture the skin. The sham...

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Abstract

The invention discloses a medicine composition for treating myocardial infarction and an application of the medicine composition. The composition is prepared from the following traditional Chinese medicinal raw materials in parts by weight: 20-40 parts of Chinese fan palm leaf, 35-70 parts of sophora flower, 10-18 parts of wild jujube, 11-20 parts of jackinthepulpit tuber, 6-10 parts of rhizoma corydalis, 6-10 parts of rhubarb, 9-22 parts of gastrodia elata, 6-10 parts of mangnolia officinalis and 15-30 parts of malt. The medicine composition has better activity of treating the myocardial infarction, and a complete medicine effect, can rapidly improve a condition of a patient with the myocardial infarction, and has good basic clinical application prospects.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, in particular to a pharmaceutical composition for treating myocardial infarction and its application. Background technique [0002] With the development of population aging, the incidence of acute myocardial infarction in my country shows a clear upward trend, which is close to the international average level. In recent years, due to the improvement of monitoring and treatment levels, the mortality rate of myocardial infarction has been significantly reduced, but the risk of acute cardiovascular events such as myocardial infarction, congestive heart failure, and comminuted death among surviving patients is still high. Therefore, in addition to active treatment in the acute phase, secondary prevention after myocardial infarction should also be strengthened. [0003] Currently, drugs for the treatment of myocardial infarction include: 1) β-receptor blockers; 2) angiotensin re...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8998A61P9/10
CPCA61K9/0053A61K9/1652A61K36/489A61K36/575A61K36/66A61K36/708A61K36/725A61K36/8884A61K36/889A61K36/8988A61K36/8998A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 安佰海韩晶崔金兴周景想
Owner 安佰海
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