Tetracaine hydrochloride oral cavity anesthetic liquid and preparation method thereof

Abstract

The invention provides a tetracaine hydrochloride oral cavity anesthetic liquid. The tetracaine hydrochloride oral cavity anesthetic liquid is prepared from the following raw materials: tetracaine hydrochloride, chlorhexidine acetate, glycerol, peppermint oil and saccharin sodium. The invention further provides a preparation method of the tetracaine hydrochloride oral-cavity anesthetic liquid. The preparation method of the tetracaine hydrochloride oral-cavity anesthetic liquid comprises the following steps: (1) weighing the tetracaine hydrochloride and the chlorhexidine acetate in proportion, adding the tetracaine hydrochloride and the chlorhexidine acetate in distilled water at 100 DEG C, stirring until the tetracaine hydrochloride and the chlorhexidine acetate are dissolved, and standing so as to reduce the temperature to 50-60 DEG C to obtain a solution 1; and (2) mixing the peppermint oil with the same amount of tween-80 and then adding the mixture, the glycerol and the saccharin sodium into the solution 1 obtained in the last step, stirring until the glycerol and the saccharin sodium are dissolved, adding distilled water at 50-60 DEG C till requisite amount, and uniformly mixing to obtain the tetracaine hydrochloride oral-cavity anesthetic liquid. The tetracaine hydrochloride oral cavity anesthetic liquid disclosed by the invention has the beneficial effects that an oral cavity surface anesthetic effect can be sufficiently perfected for a patient subjected to awake tracheal intubation, a patient with oral cavity operation or a patient subjected to other associated operations of an oral cavity, the comfort level of the patient in an awake tracheal intubation process, surgical procedures or other associated operations is improved, and the pains of the patient are reduced to the greatest extent.

Description

technical field [0001] The invention relates to an oral anesthesia liquid, in particular to a tetracaine hydrochloride oral anesthesia liquid and a preparation method thereof. Background technique [0002] In clinical anesthesia, tracheal intubation to control breathing in patients under general anesthesia is one of the essential measures to manage the airway. However, for patients with difficult airway, after induction of general anesthesia, the glottis cannot be exposed, or the endotracheal tube cannot be inserted into the glottis after blind exploration, which will seriously threaten the patient's life safety. In mild cases, the operation was canceled, and in severe cases, hypoxia CO 2 Accumulation, cardiac arrest. Therefore, clinical anesthesiologists usually choose awake tracheal intubation for such patients with difficult tracheal intubation. Endotracheal intubation in the awake state is an extremely painful process for the patient. Although the anesthesiolo...

AI Technical Summary

Problems solved by technology

However, for patients with difficult airway, after induction of general anesthesia, the glottis cannot be exposed, or the endotracheal tube cannot be inserted into the glottis after blind exploration, which will seriously threaten the patient's life safety