A kind of preparation method of frankincense granule

Abstract

The invention provides a preparation method for frankincense particles. The preparation method comprises the following steps of adding frankincense in boiling water with a mass of 1-20 times that of the frankincense; stirring and decocting for 0.5-2 hours while keeping the boiling state; then adding a water-soluble starch type auxiliary material with a mass of 5-40% that of the frankincense; stirring to dissolve the auxiliary material; separating a medicinal solution from decoction dregs, the medicinal solution being a first decoction extracting liquid; adding water with a mass of 8-12 times that of the frankincense, heating to a boiling state, decocting for 0.25-1 hour, merging the liquid with the first decoction extracting liquid to obtain a frankincense extracting liquid; concentrating the frankincense extracting liquid at a temperature of 50-80 DEG C to a mass of 2.5-5 times that of the frankincense to obtain frankincense clear paste; heating the frankincense clear paste to a temperature higher than 95 DEG C and spray drying to obtain frankincense spray-dried powder; granulating the frankincense spray-dried powder by a dry method to obtain frankincense particles. The preparation technology is simple; conditions are mild; parameters can be controlled easily; extraction efficiency is high; and dissolubility of a finished product is good.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine extraction and preparation, and in particular relates to a preparation method of frankincense granules. Background technique [0002] Frankincense is the resin exuded from the bark of Boswelliacarterii Birdw. and Boswelliabhaw-dajiana Birdw., a plant of the olive family. Frankincense is pungent and warming, has the effect of activating blood and relieving pain, reducing swelling and promoting granulation. It is mainly used to treat chest pain and heartache, epigastric pain, dysmenorrhea, postpartum stasis, abdominal pain, rheumatic arthralgia, tendon spasm, bruises , carbuncles, sores, etc., are widely used clinically in the treatment of rheumatism, rheumatoid arthritis and osteoarthritis. Frankincense mainly contains three major components of oleoresin, gum and volatile oil. Modern pharmacological studies have shown that the boswellic acid compounds contained in it have ant...

AI Technical Summary

Problems solved by technology

[0004] At present, frankincense formula granules have been sold on the market, but the existing frankincense formula granules are extracted by water decoction, spray-dried, and dry-pressed. Since frankincense mainly contains 60% to 70% of resin and 27% to 35% of gum. %, 3% to 8% of volatile oil, the above-mentioned ingredients are easily soluble in organic solvents, and the solubility in water is low. In the prior art, there are often the following problems when decocting and extracting frankincense formula granules:

[0005] 1. Since frankincense decoction pieces contain a large amount of resin and gum substances, their water solubility is poor. When decoction is used for extraction, the decoction pieces tend to form agglomerates and adhere to the bottom of the extraction tank, resulting in incomplete extraction, which affects product quality and quality. clinical effect

[0006] 2. Due to the poor water solubility of resins and gums, the decoction extract will have a large amount of precipitation as the temperature of the solution decreases and the concentration of the solution increases. The precipitates are easy to adhere to the pipe wall, and even block the pipe, resulting in concentration Impossible, at the same time, it will increase the difficulty of cleaning the concentration equipment

[0007] 3. The frankincense extract is directly spray-dried, and the spray-dried powder is easy to stick to the wall, resulting in a large loss of spray-dried powder and low yield of spray-dried powder

[0008] 4. Due to the poor water solubility of resins and gums, ordinary granules prepared from frankincense extracts have poor water solubility and are inconvenient to take. If they are prepared into suspension or effervescent special granules, the increase will be significant. The amount of excipients cannot achieve the effect of reducing the dosage

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