A kind of preparation method of frankincense granule

A technology of frankincense and granules, applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc. and carry, reduce the amount of auxiliary materials, and the effect of good solubility of the finished product

Active Publication Date: 2017-04-19
广东省中医药工程技术研究院
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Problems solved by technology

[0004] At present, frankincense formula granules have been sold on the market, but the existing frankincense formula granules are extracted by water decoction, spray-dried, and dry-pressed. Since frankincense mainly contains 60% to 70% of resin and 27% to 35% of gum. %, 3% to 8% of volatile oil, the above-mentioned ingredients are easily soluble in organic solvents, and the solubility in water is low. In the prior art, there are often the following problems when decocting and extracting frankincense formula granules:
[0005] 1. Since frankincense decoction pieces contain a large amount of resin and gum substances, their water solubility is poor. When decoction is used for extraction, the decoction pieces tend to form agglomerates and adhere to the bottom of the extraction tank, resulting in incomplete extraction, which affects product quality and quality. clinical effect
[0006] 2. Due to the poor water solubility of resins and gums, the decoction extract will have a large amount of precipitation as the temperature of the solution decreases and the concentration of the solution increases. The precipitates are easy to adhere to the pipe wall, and even block the pipe, resulting in concentration Impossible, at the same time, it will increase the difficulty of cleaning the concentration equipment
[0007] 3. The frankincense extract is directly spray-dried, and the spray-dried powder is easy to stick to the wall, resulting in a large loss of spray-dried powder and low yield of spray-dried powder
[0008] 4. Due to the poor water solubility of resins and gums, ordinary granules prepared from frankincense extracts have poor water solubility and are inconvenient to take. If they are prepared into suspension or effervescent special granules, the increase will be significant. The amount of excipients cannot achieve the effect of reducing the dosage

Method used

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  • A kind of preparation method of frankincense granule
  • A kind of preparation method of frankincense granule
  • A kind of preparation method of frankincense granule

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preparation example Construction

[0021] The embodiment of the present invention provides a preparation method of frankincense granules, which comprises the following steps:

[0022] S01: Add frankincense to boiling water 10-20 times its mass, stir and keep boiling for 0.5-2 hours, then add water-soluble starch-based auxiliary materials with 5-40% of the mass of frankincense, stir until the auxiliary materials dissolve, and The medicinal liquid is separated from the medicinal residue, and the medicinal liquid is the first decoction extract;

[0023] S02: adding water in an amount 8 to 12 times the mass of the frankincense to the medicinal dregs, heating to boiling and decocting for 0.25 to 1 hour, then taking the liquid and combining it with the first decoction extract to obtain an extract of frankincense;

[0024] S03: Concentrating the frankincense extract at 50-80°C to 2.5-5 times the mass of the frankincense to obtain a frankincense ointment;

[0025] S04: heating the frankincense ointment to above 95°C, ...

Embodiment 1

[0034] Frankincense decoction pieces 100kg, add water and decoct twice, first add 15 times the amount of water to the extraction tank, heat and boil, keep slightly boiled, turn on the mixer in the extraction tank, stirring speed 60rpm, add frankincense decoction pieces in batches , after feeding, keep stirring, heat and decoct for 1.5 hours, add 25% of the amount of maltodextrin in the decoction pieces, and stir for 10 minutes. Extraction solution: add 8 times the amount of water for the second time, heat and decoct for 0.5 hours, filter the extraction solution, merge with the first decoction extraction solution, and obtain the frankincense extract solution; pump the frankincense extract solution into the concentrator, The concentration temperature is controlled between 50 and 80°C. When the extract is concentrated to 4.3 times the amount of feed, it is filtered through a 250-mesh sieve while it is hot to obtain frankincense cream; Heating to not lower than 95°C, spraying dryi...

Embodiment 2

[0038] Receive 100kg of vinegar and frankincense decoction pieces, add water and decoct twice. For the first time, add 16 times the amount of water to the extraction tank. After heating and boiling, keep a slight boil. Turn on the mixer of the extraction tank, stirring at a speed of 50rpm, and add in batches Vinegar frankincense decoction pieces, after feeding, keep stirring, heat and decoct for 1.5 hours, add 30% soluble starch of the decoction pieces, stir for 10 minutes, after all the auxiliary materials are dissolved, extract the medicinal solution, filter the extract, and obtain the first First decoct the extract; for the second time add 10 times the amount of water, heat and decoct for 0.5 hours, filter the extract, combine with the first decoction extract to obtain the frankincense extract, pump the frankincense extract into concentrated When the concentration temperature is controlled between 50 and 80°C, when the extract is concentrated to 4.5 times the amount of feed,...

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Abstract

The invention provides a preparation method for frankincense particles. The preparation method comprises the following steps of adding frankincense in boiling water with a mass of 1-20 times that of the frankincense; stirring and decocting for 0.5-2 hours while keeping the boiling state; then adding a water-soluble starch type auxiliary material with a mass of 5-40% that of the frankincense; stirring to dissolve the auxiliary material; separating a medicinal solution from decoction dregs, the medicinal solution being a first decoction extracting liquid; adding water with a mass of 8-12 times that of the frankincense, heating to a boiling state, decocting for 0.25-1 hour, merging the liquid with the first decoction extracting liquid to obtain a frankincense extracting liquid; concentrating the frankincense extracting liquid at a temperature of 50-80 DEG C to a mass of 2.5-5 times that of the frankincense to obtain frankincense clear paste; heating the frankincense clear paste to a temperature higher than 95 DEG C and spray drying to obtain frankincense spray-dried powder; granulating the frankincense spray-dried powder by a dry method to obtain frankincense particles. The preparation technology is simple; conditions are mild; parameters can be controlled easily; extraction efficiency is high; and dissolubility of a finished product is good.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine extraction and preparation, and in particular relates to a preparation method of frankincense granules. Background technique [0002] Frankincense is the resin exuded from the bark of Boswelliacarterii Birdw. and Boswelliabhaw-dajiana Birdw., a plant of the olive family. Frankincense is pungent and warming, has the effect of activating blood and relieving pain, reducing swelling and promoting granulation. It is mainly used to treat chest pain and heartache, epigastric pain, dysmenorrhea, postpartum stasis, abdominal pain, rheumatic arthralgia, tendon spasm, bruises , carbuncles, sores, etc., are widely used clinically in the treatment of rheumatism, rheumatoid arthritis and osteoarthritis. Frankincense mainly contains three major components of oleoresin, gum and volatile oil. Modern pharmacological studies have shown that the boswellic acid compounds contained in it have ant...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K36/324A61K47/36A61J3/00
CPCA61J3/00A61K9/1652A61K36/324A61K2236/331A61K2236/39
Inventor 孙冬梅王洛临张建军陈玉兴施之琪
Owner 广东省中医药工程技术研究院
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