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Method for preparing balanced salt flushing liquid used for joint operation

A salt balance technology for surgery, applied in the medical field, can solve the problems of low dosage and inability to use

Inactive Publication Date: 2015-02-04
ZHEJIANG TIANRUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the irrigating fluid used in gynecological laparoscopic surgery is only used to wash the wound when separating the lesion or after excision of the lesion tissue, the dosage is relatively small, and a washing machine is needed to assist washing, and diabetic patients cannot use 5% G.S solution

Method used

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  • Method for preparing balanced salt flushing liquid used for joint operation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] 1) Add water for injection of 25% of the total volume of formula water for injection in the concentrated preparation tank;

[0041] 2) Add 8kg of sodium chloride, 8kg of sodium gluconate, 6kg of sodium acetate, 0.6kg of potassium chloride, 0.4kg of magnesium chloride, 0.4kg of acetic acid, and stir for 13 minutes;

[0042] 3) Add activated carbon for needles, stir evenly, absorb for 13 minutes, decarbonize through titanium rods, filter until diluted with tank, add water for injection to the full amount;

[0043] 4) Adjust the pH to between 6.8 and 7.4. After the intermediate is qualified, the end is finely filtered through a filter element, potted, and sterilized in a water bath at 110°C for 3 minutes;

[0044] 5) Leak detection, light inspection, packaging, and storage to obtain the balanced salt flushing solution for joint surgery.

[0045] The amount of active carbon for injection in the step 3) is 0.08% of the weight of water for injection in the concentrated prepa...

Embodiment 2

[0052] 1) Add water for injection of 30% of the total volume of the formula water for injection in the concentrated preparation tank;

[0053] 2) Add 10.52kg of sodium chloride, 10.04kg of sodium gluconate, 7.36kg of sodium acetate trihydrate, 0.74kg of potassium chloride, 0.6kg of magnesium chloride hexahydrate, 0.5kg of diacetic acid and stir for 15min;

[0054] 3) Add activated carbon for needles, stir evenly, absorb for 15 minutes, decarbonize through titanium rods, filter until diluted with tanks, and add water for injection to the full amount;

[0055] 4) Adjust the pH to between 6.8 and 7.4. After the intermediate is qualified, the end is finely filtered through a filter element, potted, and sterilized in a water bath at 115°C for 40 minutes;

[0056] 5) Leak detection, light inspection, packaging, and storage to obtain the balanced salt flushing solution for joint surgery.

[0057] The added amount of activated carbon for needles in the step 3) is 0.1% of the weight o...

Embodiment 3

[0064] 1) Add water for injection of 35% of the total volume of formula water for injection in the concentrated preparation tank;

[0065] 2) Add 12kg of sodium chloride, 12kg of sodium gluconate, 9kg of sodium acetate, 0.9kg of potassium chloride, 0.8kg of magnesium chloride, 0.6kg of acetic acid, and stir for 17 minutes;

[0066] 3) Add activated carbon for needles, stir evenly, absorb for 17 minutes, decarbonize through titanium rods, filter until diluted with tank, add water for injection to the full amount;

[0067] 4) Adjust the pH to between 6.8 and 7.4. After the intermediate is qualified, the end is finely filtered through a filter element, potted, and sterilized in a water bath at 120°C for 45 minutes;

[0068] 5) Leak detection, light inspection, packaging, and storage to obtain the balanced salt flushing solution for joint surgery.

[0069] The added amount of active carbon for needles in the step 3) is 0.12% of the weight of water for injection in the concentrate...

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Abstract

The invention discloses a method for preparing balanced salt flushing liquid used for joint operation. The method includes following steps: adding water for injection accounting for 25-35% of total volume of the water for injection in a formula into a concentrating-preparation pot; adding 8-12 parts by weight of sodium chloride, 8-12 parts by weight of sodium gluconate, 6-9 parts by weight of sodium acetate, 0.6-0.9 parts by weight of potassium chloride, 0.4-0.8 parts by weight of magnesium chloride and 0.4-0.6 parts by weight of acetic acid with stirring for 13-17 min; adding needle-use activated carbon with stirring uniformly; performing adsorption for 13-17 min; removing the activated carbon through titanium bars; filtering the mixed solution into a diluting-preparation pot with addition of the water for injection to total amount; adjusting the pH value to between 6.8-7.4; performing refined filtration and encapsulation to an end after the liquid being qualified through intermediate detection; performing sterilization in a water bath at 110-120 DEG C for 35-45 min; and performing leakage test, light test, packaging and a storage process to obtain the balanced salt flushing liquid used for joint operation. The balanced salt flushing liquid does not cause acidosis and can prevent and treat the acidosis.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a method for preparing balanced salt flushing solution for joint surgery. Background technique [0002] In order to obtain a clearer view during joint surgery, it is often necessary to lavage and flush the joint during the operation, and after the operation is completed, the operation area also needs to be rinsed to remove residual blood, broken bones and Microorganisms such as bacteria, and the flushing fluid can also be used as a carrier of drugs such as antibiotics, thereby preventing infection and reducing postoperative complications. [0003] At present, there are few irrigating fluids specially used for surgical operations and minimally invasive operations in China. Instead, various injections are used instead of irrigating fluids, such as 0.9% sodium chloride and 5% glucose injection. However, there is no indication for flushing solution in the instructions of these inje...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/14A61K9/08A61P7/00A61P31/02
CPCA61K33/14A61K9/08A61K31/19A61K31/191A61K33/06
Inventor 崔友李伟王恒彩夏小秋高余芬
Owner ZHEJIANG TIANRUI PHARMA
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